NCT00037349

Brief Summary

To investigate whether impaired heart-rate recovery after exercise is a powerful and independent predictor of mortality.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Timeline
Completed

Started Mar 2001

Typical duration for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 1, 2001

Completed
1.2 years until next milestone

First Submitted

Initial submission to the registry

May 16, 2002

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 17, 2002

Completed
1.7 years until next milestone

Study Completion

Last participant's last visit for all outcomes

February 1, 2004

Completed
Last Updated

February 18, 2016

Status Verified

January 1, 2005

First QC Date

May 16, 2002

Last Update Submit

February 17, 2016

Conditions

Cardiovascular DiseasesHeart Diseases

Eligibility Criteria

AgeUp to 100 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Related Publications (16)

  • Lauer MS, Alexe S, Pothier Snader CE, Blackstone EH, Ishwaran H, Hammer PL. Use of the logical analysis of data method for assessing long-term mortality risk after exercise electrocardiography. Circulation. 2002 Aug 6;106(6):685-90. doi: 10.1161/01.cir.0000024410.15081.fd.

    PMID: 12163428BACKGROUND

  • Pereira JJ, Lauer MS, Bashir M, Afridi I, Blackstone EH, Stewart WJ, McCarthy PM, Thomas JD, Asher CR. Survival after aortic valve replacement for severe aortic stenosis with low transvalvular gradients and severe left ventricular dysfunction. J Am Coll Cardiol. 2002 Apr 17;39(8):1356-63. doi: 10.1016/s0735-1097(02)01759-x.

    PMID: 11955855BACKGROUND

  • Watanabe J, Thamilarasan M, Blackstone EH, Thomas JD, Lauer MS. Heart rate recovery immediately after treadmill exercise and left ventricular systolic dysfunction as predictors of mortality: the case of stress echocardiography. Circulation. 2001 Oct 16;104(16):1911-6.

    PMID: 11602493BACKGROUND

  • Lauer MS. Exercise testing for assessment of autonomic function. Am Heart J. 2002 Oct;144(4):580-2. doi: 10.1067/mhj.2002.124830. No abstract available.

    PMID: 12360151BACKGROUND

  • Frolkis JP, Pothier CE, Blackstone EH, Lauer MS. Frequent ventricular ectopy after exercise as a predictor of death. N Engl J Med. 2003 Feb 27;348(9):781-90. doi: 10.1056/NEJMoa022353.

    PMID: 12606732BACKGROUND

  • Shishehbor MH, Baker DW, Blackstone EH, Lauer MS. Association of educational status with heart rate recovery: a population-based propensity analysis. Am J Med. 2002 Dec 1;113(8):643-9. doi: 10.1016/s0002-9343(02)01324-4.

    PMID: 12505114BACKGROUND

  • Lauer MS, Froelicher V. Abnormal heart-rate recovery after exercise. Lancet. 2002 Oct 12;360(9340):1176-7. doi: 10.1016/S0140-6736(02)11224-4. No abstract available.

    PMID: 12387983BACKGROUND

  • Ellis K, Pothier CE, Blackstone EH, Lauer MS. Is systolic blood pressure recovery after exercise a predictor of mortality? Am Heart J. 2004 Feb;147(2):287-92. doi: 10.1016/j.ahj.2003.08.009.

    PMID: 14760327BACKGROUND

  • Vivekananthan DP, Blackstone EH, Pothier CE, Lauer MS. Heart rate recovery after exercise is a predictor of mortality, independent of the angiographic severity of coronary disease. J Am Coll Cardiol. 2003 Sep 3;42(5):831-8. doi: 10.1016/s0735-1097(03)00833-7.

    PMID: 12957428BACKGROUND

  • Cheng YJ, Lauer MS, Earnest CP, Church TS, Kampert JB, Gibbons LW, Blair SN. Heart rate recovery following maximal exercise testing as a predictor of cardiovascular disease and all-cause mortality in men with diabetes. Diabetes Care. 2003 Jul;26(7):2052-7. doi: 10.2337/diacare.26.7.2052.

    PMID: 12832312BACKGROUND

  • Seshadri N, Gildea TR, McCarthy K, Pothier C, Kavuru MS, Lauer MS. Association of an abnormal exercise heart rate recovery with pulmonary function abnormalities. Chest. 2004 Apr;125(4):1286-91. doi: 10.1378/chest.125.4.1286.

    PMID: 15078736BACKGROUND

  • Chen MS, Blackstone EH, Pothier CE, Lauer MS. Heart rate recovery and impact of myocardial revascularization on long-term mortality. Circulation. 2004 Nov 2;110(18):2851-7. doi: 10.1161/01.CIR.0000147539.39775.F4. Epub 2004 Oct 25.

    PMID: 15505081BACKGROUND

  • Aktas MK, Ozduran V, Pothier CE, Lang R, Lauer MS. Global risk scores and exercise testing for predicting all-cause mortality in a preventive medicine program. JAMA. 2004 Sep 22;292(12):1462-8. doi: 10.1001/jama.292.12.1462.

    PMID: 15383517BACKGROUND

  • Christopher Jones R, Pothier CE, Blackstone EH, Lauer MS. Prognostic importance of presenting symptoms in patients undergoing exercise testing for evaluation of known or suspected coronary disease. Am J Med. 2004 Sep 15;117(6):380-9. doi: 10.1016/j.amjmed.2004.06.004.

    PMID: 15380494BACKGROUND

  • O'Neill JO, Young JB, Pothier CE, Lauer MS. Severe frequent ventricular ectopy after exercise as a predictor of death in patients with heart failure. J Am Coll Cardiol. 2004 Aug 18;44(4):820-6. doi: 10.1016/j.jacc.2004.02.063.

    PMID: 15312865BACKGROUND

  • Lauer MS. Clinical epidemiology, clinical care, and the public's health. Mayo Clin Proc. 2004 Aug;79(8):975-6. doi: 10.4065/79.8.975. No abstract available.

    PMID: 15301321BACKGROUND

MeSH Terms

Conditions

Cardiovascular DiseasesHeart Diseases

Study Officials

  • Michael Lauer

    The Cleveland Clinic

Study Design

Study Type
observational
Sponsor Type
NIH

Study Record Dates

First Submitted

May 16, 2002

First Posted

May 17, 2002

Study Start

March 1, 2001

Study Completion

February 1, 2004

Last Updated

February 18, 2016

Record last verified: 2005-01