Healthy Aging and Memory Study
Alzheimer's Disease Prevention Instrument Protocol
1 other identifier
observational
650
1 country
39
Brief Summary
This project will focus on the development and testing of efficient, cost effective measures that are specifically designed for use in Alzheimer's Disease (AD) primary prevention trials.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
39 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
April 30, 2002
CompletedFirst Posted
Study publicly available on registry
May 1, 2002
CompletedSeptember 18, 2007
September 1, 2007
April 30, 2002
September 14, 2007
Conditions
Keywords
Eligibility Criteria
You may qualify if:
- years or older.
- Fluent in English or Spanish.
- Stable medical condition for four weeks prior to screening visit.
- Stable medications for four weeks prior to screening visit.
- Either cognitively normal, or mild cognitive impairment. If MCI, the subject's CDR at screening have a global score of 0.5.
- mMMSE score greater than 88 for subjects with at least 8 years education, or greater than 80 for subjects with less than 8 years education, and FCSRT total free plus cued recall score greater than 44 with 3 learning trials.
- Willing to participate in four to five year follow-up study.
- Willing to identify person who can serve as informant.
- At least six years education or work history sufficient to exclude mental retardation
You may not qualify if:
- Meets DSM IV criteria for dementia
- History of clinically significant medical illness that would interfere with participation in trial, including active malignancy, myocardial infarction, or cerebrovascular accident within the past year
- Alcohol or substance abuse and/or active major psychiatric disorders
- Concurrent participation in a clinical drug trial
- History of mental retardation
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (39)
University of Alabama, Birmingham
Birmingham, Alabama, 35294-1150, United States
Sun Health Research Institute
Sun City, Arizona, 85351, United States
University of California, Irvine
Irvine, California, 92697-4285, United States
University of California, San Diego
La Jolla, California, 92037, United States
University of Southern California
Los Angeles, California, 90033-1039, United States
University of California, Los Angeles
Los Angeles, California, 90095-1769, United States
Stanford/Va Aging Clinical Research Center
Palo Alto, California, 94304, United States
University of California, Davis
Sacramento, California, 95817, United States
Yale University School of Medicine
New Haven, Connecticut, 06510, United States
Georgetown University Medical Center
Washington D.C., District of Columbia, 20007, United States
Baumel-Eisner Neuromedical Institute, Boca Raton
Boca Raton, Florida, 33486, United States
Baumel-Eisner Ft Lauderdale
Fort Lauderdale, Florida, 33321, United States
Mayo Clinic, Jacksonville
Jacksonville, Florida, 32224, United States
Wien Center for Memory Disorders
Miami Beach, Florida, 33140, United States
Baumel-Eisner Neuromedical Institute, Miami Beach
Miami Beach, Florida, 33154, United States
University of South Florida, Tampa
Tampa, Florida, 33617, United States
Emory University
Atlanta, Georgia, 30329, United States
Northwestern University
Chicago, Illinois, 60611, United States
Rush Alzheimer's Disease Center
Chicago, Illinois, 60612, United States
Indiana University Alzheimer's Center
Indianapolis, Indiana, 46202, United States
University of Kentucky, Lexington
Lexington, Kentucky, 40506, United States
Johns Hopkins University
Baltimore, Maryland, 21287-7218, United States
Brigham and Women's Hospital
Boston, Massachusetts, 02115, United States
Boston University School of Medicine
Boston, Massachusetts, 02118, United States
Michigan Alzheimer's Disease Research Center
Ann Arbor, Michigan, 48109-2007, United States
Mayo Alzheimer's Disease Center
Rochester, Minnesota, 55901, United States
Washington University
St Louis, Missouri, 63108, United States
University of Nevada, Las Vegas
Las Vegas, Nevada, 89102, United States
New York University School of Medicine
New York, New York, 10016, United States
Mt. Sinai Medical Center
New York, New York, 10029, United States
Columbia University
New York, New York, 10032, United States
University of Rochester
Rochester, New York, 14620, United States
University Hospitals of Cleveland
Cleveland, Ohio, 44120-1013, United States
Oregon Health Sciences University
Portland, Oregon, 97201, United States
University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
University of Pittsburgh
Pittsburgh, Pennsylvania, 15213, United States
Memorial Hospital of Rhode Island (Brown University)
Pawtucket, Rhode Island, 02860, United States
Medical University of South Carolina
North Charleston, South Carolina, 29406, United States
University of Texas Southwestern Medical Center
Dallas, Texas, 75390-9070, United States
Related Publications (7)
Ferris SH, Aisen PS, Cummings J, Galasko D, Salmon DP, Schneider L, Sano M, Whitehouse PJ, Edland S, Thal LJ; Alzheimer's Disease Cooperative Study Group. ADCS Prevention Instrument Project: overview and initial results. Alzheimer Dis Assoc Disord. 2006 Oct-Dec;20(4 Suppl 3):S109-23. doi: 10.1097/01.wad.0000213870.40300.21.
PMID: 17135805RESULTSchneider LS, Clark CM, Doody R, Ferris SH, Morris JC, Raman R, Reisberg B, Schmitt FA. ADCS Prevention Instrument Project: ADCS-clinicians' global impression of change scales (ADCS-CGIC), self-rated and study partner-rated versions. Alzheimer Dis Assoc Disord. 2006 Oct-Dec;20(4 Suppl 3):S124-38. doi: 10.1097/01.wad.0000213878.47924.44.
PMID: 17135806RESULTGalasko D, Bennett DA, Sano M, Marson D, Kaye J, Edland SD; Alzheimer's Disease Cooperative Study. ADCS Prevention Instrument Project: assessment of instrumental activities of daily living for community-dwelling elderly individuals in dementia prevention clinical trials. Alzheimer Dis Assoc Disord. 2006 Oct-Dec;20(4 Suppl 3):S152-69. doi: 10.1097/01.wad.0000213873.25053.2b.
PMID: 17135809RESULTSano M, Zhu CW, Whitehouse PJ, Edland S, Jin S, Ernstrom K, Thomas RG, Thal LJ, Ferris SH; Alzheimer Disease Cooperative Study Group. ADCS Prevention Instrument Project: pharmacoeconomics: assessing health-related resource use among healthy elderly. Alzheimer Dis Assoc Disord. 2006 Oct-Dec;20(4 Suppl 3):S191-202. doi: 10.1097/01.wad.0000213875.63171.87.
PMID: 17135812RESULTWalsh SP, Raman R, Jones KB, Aisen PS; Alzheimer's Disease Cooperative Study Group. ADCS Prevention Instrument Project: the Mail-In Cognitive Function Screening Instrument (MCFSI). Alzheimer Dis Assoc Disord. 2006 Oct-Dec;20(4 Suppl 3):S170-8. doi: 10.1097/01.wad.0000213879.55547.57.
PMID: 17135810RESULTCummings JL, Raman R, Ernstrom K, Salmon D, Ferris SH; Alzheimer's Disease Cooperative Study Group. ADCS Prevention Instrument Project: behavioral measures in primary prevention trials. Alzheimer Dis Assoc Disord. 2006 Oct-Dec;20(4 Suppl 3):S147-51. doi: 10.1097/01.wad.0000213872.17429.0f.
PMID: 17135808RESULTPatterson MB, Whitehouse PJ, Edland SD, Sami SA, Sano M, Smyth K, Weiner MF; Alzheimer's Disease Cooperative Study Group. ADCS Prevention Instrument Project: quality of life assessment (QOL). Alzheimer Dis Assoc Disord. 2006 Oct-Dec;20(4 Suppl 3):S179-90. doi: 10.1097/01.wad.0000213874.25053.e5.
PMID: 17135811RESULT
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Steven H. Ferris, PhD
NYU Langone Health
Study Design
- Study Type
- observational
- Observational Model
- DEFINED POPULATION
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- NIH
Study Record Dates
First Submitted
April 30, 2002
First Posted
May 1, 2002
Last Updated
September 18, 2007
Record last verified: 2007-09