Ginkgo Biloba: Antidepressant-Induced Sexual Dysfunction

NCT00034021 | Completed Phase 2

• 1 other identifier: R01AT000224-01A2
• Study Type: interventional
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to provide the first empirical examination of the effects of Ginkgo biloba (GBE), sex therapy, and a combination of the two on subjective and physiological measures of sexual function in women who are experiencing sexual disorders secondary to antidepressants.

Conditions

Hypoactive Sexual Desire Disorder; Sexual Dysfunctions, Psychological

Keywords

Female Sexual Arousal Disorder; Female Orgasmic Disorder; ginkgo biloba; human therapy evaluation; sex behavior; antidepressant; blood flow; clinical trial; drug adverse effect; mental disorder chemotherapy; relaxation; smooth muscle; alternative medicine; blood flow measurement; female; placebo; women's health; Secondary to either to fluoxetine, sertraline, or paroxetine use.

Interventions

Ginkgo Biloba DRUG

Sex Therapy (genital focus) BEHAVIORAL

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Proficient in English
• Patients must be currently involved in a heterosexual relationship in which they are willing to engage in at least two sexual encounters (with intent to attain orgasm) per week during the course of the study;
• Patients who report an onset of Hypoactive Sexual Desire Disorder, Female Sexual Arousal Disorder, or Female Orgasmic Disorder no less than one week and no more than 3 months after beginning treatment with either fluoxetine, sertraline, or paroxetine;
• Patients who have been receiving treatment with either fluoxetine, sertraline, or paroxetine for a minimum of 10 weeks (and are currently receiving fluoxetine, sertraline, or paroxetine treatment);
• Subjects must describe the sexual dysfunction as following the otherwise successful treatment with the antidepressant, and as being distinctly different from any sexual dysfunction they may have noticed prior to starting antidepressant treatment.
• Patients must agree to not use aspirin during the course of the study, and agree to use a medically accepted form of birth control for the duration of the study.
• Patients must agree to not supplement their diet with GBE throughout the duration of the study (outside of that which they receive as part of the study medication).
• Patient must live in Austin Texas

You may not qualify if:

• Under the age of 18 or over the age of 65
• Subjects with amenorrhea for \> 6 months.
• Women who are pregnant (as determined by a pregnancy test) or are intending to become pregnant during the course of the study, and subjects who are lactating or are \<1 year post-partum.
• Patients with a history of bleeding disorders.
• History of HIV infection or active, untreated pelvic or urinary tract infection including, sexually transmitted diseases such as chlamydia, genital herpes, gonorrhea, or syphilis.
• Major pelvic surgery that may have caused nerve damage, including: vulvectomy, circumcision, colostomy, cystostomy, or serious bladder, rectal, or abdominal surgery.
• Neurological impairment due to diabetes, stroke, pelvic nerve damage secondary to trauma, cancer treatments, myasthenia gravis, multiple sclerosis or spinal cord damage.
• Clinically significant untreated renal or endocrine disease. Uncontrolled hypotension or hypertension manifested by systolic blood pressure \>170 or \<90 mm Hg or diastolic blood pressure \>100 or \<50 mm Hg (if stress is suspected, participants will be retested under basal conditions).
• Patients with any supraventricular arrhythmia with an uncontrolled ventricular response (mean heart rate \>100 bpm) at rest despite medical or device therapy, or any history of spontaneous or induced sustained ventricular tachycardia (heart rate \>100 bpm for \>30 sec) despite medical or device therapy, or the presence of an automatic internal cardioverter defibrillator.
• A history of sudden cardiac arrest despite medical or device therapy, or any evidence of congestive heart failure within 6 months prior to the first visit.
• Hamilton Depression Rating Scale (HAM-D) score greater than or equal to 15.
• History of drug, alcohol, or substance abuse within the past 6 months.
• Evidence of an untreated Axis I psychiatric disorder, including schizophrenia, manic-depressive disorder, delusional disorder, or psychotic disorders not classified elsewhere.
• Patients who are not currently involved in a heterosexual relationship in which they are willing to engage in at least two sexual encounters per week.
• Subjects with a history of sexual trauma (defined as serious distress caused by unwanted or coercive sexual activity), including sexual abuse, molestation, rape, and sexual phobias.

Sponsors & Collaborators

• National Center for Complementary and Integrative Health (NCCIH): lead

Study Sites (1)

University of Texas, Austin

Austin, Texas, 78757, United States

Location

Related Links

• Click here to learn more about the Female Sexual Psychophysiology Laboratory at the University of Texas at Austin.

MeSH Terms

Conditions

Sexual Dysfunctions, Psychological; Sexual Behavior; Drug-Related Side Effects and Adverse Reactions

Interventions

Ginkgo Extract

Condition Hierarchy (Ancestors)

Mental Disorders; Behavior; Chemically-Induced Disorders

Intervention Hierarchy (Ancestors)

Plant Extracts; Plant Preparations; Biological Products; Complex Mixtures

Study Officials

• Cindy Meston, PhD

  University of Texas at Austin

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: NIH

Study Record Dates

• First Submitted: April 19, 2002
• First Posted: April 22, 2002
• Study Start: June 1, 2002
• Study Completion: September 1, 2004
• Last Updated: August 18, 2006

Record last verified: 2006-07

Locations

US (1)