NCT00032864

Brief Summary

A Seattle VA study indicated lower extremity ulcers preceded 84% of diabetic amputations. Nearly half of the events that ban the causal chain leading to ulcers and amputation were initiated by ill-fitting footwear. Other investigators report similar findings for injurious footwear in their diabetic patient populations. Yet, the efficacy of footwear in preventing ulcers and amputations in the high-risk diabetic population has received limited experimental investigation. A British descriptive study followed diabetic patients with healed foot ulcers for two years and found reulceration occurred in 72% of patients who resume wearing their own footwear compared to 26% of patients who continued wearing "prescribed" footwear. A Swedish cohort study identified individuals with a foot ulcer and reported their 1, 3, and 5 year reulceration rates at 34%, 61%, and 70%, respectively, without further specifying footwear components. In a German diabetic population the reulceration rate was 87% in-patients who abandoned their custom shoes and resumed wearing their own shoes compared to 42% of those who continued to wear their custom shoes. Unfortunately, none of these studies compared the single or combined contribution of therapeutic shoes or insoles on foot ulcer prevention. Nor did these studies address patient adherence to prescribed footwear; thus the actual efficacy of various footwear interventions in foot ulcer prevention in this high-risk population is still to be tested.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Timeline
Completed

Started Jan 1997

Typical duration for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 1997

Completed
3.7 years until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2000

Completed
1.6 years until next milestone

First Submitted

Initial submission to the registry

April 4, 2002

Completed
1 day until next milestone

First Posted

Study publicly available on registry

April 5, 2002

Completed
Last Updated

January 21, 2009

Status Verified

February 1, 2003

First QC Date

April 4, 2002

Last Update Submit

January 20, 2009

Conditions

Keywords

amputations, diabetes,

Sponsors & Collaborators

MeSH Terms

Conditions

Diabetes MellitusLeg Ulcer

Condition Hierarchy (Ancestors)

Glucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System DiseasesSkin UlcerSkin DiseasesSkin and Connective Tissue Diseases

Study Design

Study Type
observational
Sponsor Type
FED

Study Record Dates

First Submitted

April 4, 2002

First Posted

April 5, 2002

Study Start

January 1, 1997

Study Completion

September 1, 2000

Last Updated

January 21, 2009

Record last verified: 2003-02