Cause, Development, and Progression of Stiff-Person Syndrome

NCT00030940 | Completed

• 2 other identifiers: 02012202-N-0122
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 2

Brief Summary

This study will explore the role of various immune factors involved in producing the disease symptoms in stiff-person syndrome (SPS) and follow disease progression in patients. SPS is a progressive disease in which unexpected noises, touches or stressful events set off muscle spasms and stiffness. It is thought to be an autoimmune disease in which the body produces antibodies that attack certain healthy tissues. A better understanding of the disease may help researchers design new therapies. Patients of any age with SPS may be eligible for this study, except those who:

• Lack of serum anti-GAD antibodies
• Have very advanced disease that precludes traveling
• Have severe cardiovascular, renal, or other end-organ-disease states Candidates will be screened with a medical history and physical and neurological examinations to confirm the diagnosis of SPS. After screening, those enrolled in the study will be followed at the NIH Clinical Center every 6 months for 2 years (months 6, 12, 18, and 24) to have the following tests and procedures:
• Physical and neurological examinations and review of symptoms (every visit)
• Blood draw for routine tests and for research studies (every visit)
• Stiffness assessment (every visit) - Patients are asked a series of questions about their stiffness, which physicians rate according to the number of stiff areas (e.g., 0-no stiff areas; 1-stiffness of the lower trunk; 2-stiffness of the upper trunk, etc.).
• Lymphapheresis (at the beginning of the study and at 12 months) - This is a procedure for collecting large quantities of white blood cells. A needle is placed in a vein in the arm. Blood flows from the vein through a plastic tube (catheter) into a machine that spins the blood, separating it into its components. The white blood cells (lymphocytes) are removed, and the rest of the blood-plasma, red cells and platelets-is returned to the body through a second needle placed in the other arm.
• Electrophysiologic studies - These studies include electromyography and nerve conduction testing. For electromyography, a small needle is inserted into a few muscles and the patient is asked to relax or to contract the muscles. The electrical activity of the muscle cells is recorded and analyzed by a computer. For nerve conduction testing, nerves are stimulated through small wire electrodes attached to the skin, and the response is recorded and analyzed.
• Lumbar puncture (at the beginning of the study and at 12 months) - This procedure is done to examine the cerebrospinal fluid (CSF), which bathes the brain and spinal cord. After a local anesthetic is administered, a needle is inserted in the space between the bones in the lower back where the CSF circulates below the spinal cord. About 2 tablespoons of fluid is collected through the needle.

Conditions

Stiff-Person Syndrome

Keywords

Antigenic Epitopes; Glutamic Acid Decarboxylase (GAD); Auto-antibodies; Stiffness Index; SPS; Anti-GAD; MR Spectroscopy; GAD; Stiff Person Syndrome

Eligibility Criteria

• Age: 25 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• All patients who fulfill the recently revised clinical criteria for SPS.

You may not qualify if:

• Lack of anti-GAD antibodies in the serum;
• Very advanced disease state that precludes traveling;
• Severe cardiovascular, renal, or other end-organ-disease states.

Sponsors & Collaborators

• National Institute of Neurological Disorders and Stroke (NINDS): lead

Study Sites (2)

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Location

Thomas Jefferson University

Philadelphia, Pennsylvania, 19107-6541, United States

Location

Related Publications (1)

• Dalakas MC, Fujii M, Li M, McElroy B. The clinical spectrum of anti-GAD antibody-positive patients with stiff-person syndrome. Neurology. 2000 Nov 28;55(10):1531-5. doi: 10.1212/wnl.55.10.1531.

  PMID: 11094109 BACKGROUND

MeSH Terms

Conditions

Stiff-Person Syndrome

Condition Hierarchy (Ancestors)

Autoimmune Diseases of the Nervous System; Nervous System Diseases; Spinal Cord Diseases; Central Nervous System Diseases; Neuromuscular Diseases; Autoimmune Diseases; Immune System Diseases

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: February 14, 2002
• First Posted: February 15, 2002
• Study Start: February 11, 2002
• Study Completion: December 28, 2007
• Last Updated: July 2, 2017

Record last verified: 2007-12-28

Locations

US (2)