Look AHEAD: Action for Health in Diabetes
LookAHEAD
17 other identifiers
interventional
5,145
1 country
18
Brief Summary
The Look AHEAD study is a multi-center, randomized clinical trial to examine the long-term effects of a lifestyle intervention designed to achieve and maintain weight loss. The study will investigate the effects of the intervention on heart attacks, stroke and cardiovascular-related death in individuals with type 2 diabetes who are also overweight or obese.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable diabetes
Started Jun 2001
Longer than P75 for not_applicable diabetes
18 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2001
CompletedFirst Submitted
Initial submission to the registry
June 21, 2001
CompletedFirst Posted
Study publicly available on registry
June 21, 2001
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
June 30, 2020
CompletedResults Posted
Study results publicly available
August 2, 2023
CompletedAugust 2, 2023
May 1, 2023
11.3 years
June 21, 2001
April 3, 2023
July 13, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
First Occurrence of a Severe Cardiovascular Event
Number of participants with first on-study occurrence of one of the following major cardiovascular events: fatal and non-fatal myocardial infarctions and strokes, hospitalizations for angina, and cardiovascular deaths
up to 11 years
Secondary Outcomes (3)
First Occurrence of Cardiovascular Death, Myocardial Infarction, or Stroke
up to 11 years
First Occurrence of Death, Myocardial Infarction, or Hospitalized Angina
up to 11 years
First Occurrence of Major Clinical Events
up to 11 years
Study Arms (2)
Lifestyle Intervention
EXPERIMENTALParticipants in the lifestyle intervention arm are offered individual and group sessions designed to help achieve and maintain weight loss.
Diabetes Support and Education
ACTIVE COMPARATORThe diabetes support and education arm provides group sessions on diabetes management and social support.
Interventions
The lifestyle intervention is implemented with individual supervision and group sessions and is aimed at achieving and maintaining at least a 7% decrease in weight from baseline and 175 minutes per week in physical activity. It is implemented during a four-year period with the most intensive application during the first year, less frequent attention during the next three years, and a minimum of twice yearly contacts during an extended follow-up period. To help participants achieve and maintain weight loss, a variety of diet strategies (e.g. prepared meals and liquid formula), exercise strategies, and optional weight loss medications are utilized based on a preset algorithm and participant progress.
Participants assigned to diabetes support and education are offered three sessions each year in diabetes management and social support.
Eligibility Criteria
You may qualify if:
- Type 2 diabetes
- Overweight
- BMI of 25 kg/m2 or greater
- If on insulin, BMI of 27 kg/m2 or greater
- Blood pressure less than 160/100 mmHg
- HbA1c less or equal to 11%
- Triglycerides less than 600 mg/dl
- Willingness to participate
You may not qualify if:
- Unable or unwilling to give informed consent or communicate with local study staff.
- Current diagnosis of schizophrenia, other psychotic disorders, or bipolar disorder.
- Hospitalization for depression in past six months.
- Self-report of alcohol or substance abuse within the past twelve months.
- Current consumption of more than 14 alcoholic drinks per week.
- Current acute treatment or rehabilitation program for these problems.
- Plans to relocate to an area not served by Look AHEAD or travel plans that do not permit full participation in the study.
- Lack of support from primary care health provider or family members.
- Failure to complete the two-week run-in for dietary intake and exercise.
- Weight loss exceeding 10 lbs. in past three months.
- Current use of medications for weight loss.
- Self reported inability to walk two blocks.
- History of bariatric surgery, small bowel resection, or extensive bowel resection.
- Chronic treatment with systemic corticosteroids.
- Another member of the household is a participant or staff member in Look AHEAD.
- +35 more criteria
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Wake Forest University Health Scienceslead
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)collaborator
- National Heart, Lung, and Blood Institute (NHLBI)collaborator
- National Institute of Nursing Research (NINR)collaborator
- National Institute on Minority Health and Health Disparities (NIMHD)collaborator
- Office of Research on Women's Health (ORWH)collaborator
- Centers for Disease Control and Preventioncollaborator
Study Sites (18)
The University of Alabama at Birmingham
Birmingham, Alabama, 35205, United States
Southwestern American Indian Center
Phoenix, Arizona, 85014, United States
University of Southern California
Los Angeles, California, 90022, United States
University of Colorado Health Sciences Center
Aurora, Colorado, 80045-0808, United States
Louisiana State University
Baton Rouge, Louisiana, 70808, United States
Johns Hopkins Pro-Health
Baltimore, Maryland, 21207, United States
Diabetes Center
Boston, Massachusetts, 02114, United States
Joslin Diabetes Center
Boston, Massachusetts, 02114, United States
University of Minnesota
Minneapolis, Minnesota, 55415-1226, United States
Northern Navajo Medical Center
Shiprock, New Mexico, 87420, United States
Columbia University
New York, New York, 10019, United States
University of Pennsylvania Medical Center
Philadelphia, Pennsylvania, 19104, United States
University of Pittsburgh
Pittsburgh, Pennsylvania, 15213, United States
The Miriam Hospital
Providence, Rhode Island, 02906, United States
The University of Tennessee, Memphis
Memphis, Tennessee, 38105, United States
Baylor College of Medicine
Houston, Texas, 77030, United States
University of Texas Health Sciences Center
San Antonio, Texas, 78229, United States
University of Washington
Seattle, Washington, 98108, United States
Related Publications (103)
Look AHEAD Research Group; Wing RR, Bolin P, Brancati FL, Bray GA, Clark JM, Coday M, Crow RS, Curtis JM, Egan CM, Espeland MA, Evans M, Foreyt JP, Ghazarian S, Gregg EW, Harrison B, Hazuda HP, Hill JO, Horton ES, Hubbard VS, Jakicic JM, Jeffery RW, Johnson KC, Kahn SE, Kitabchi AE, Knowler WC, Lewis CE, Maschak-Carey BJ, Montez MG, Murillo A, Nathan DM, Patricio J, Peters A, Pi-Sunyer X, Pownall H, Reboussin D, Regensteiner JG, Rickman AD, Ryan DH, Safford M, Wadden TA, Wagenknecht LE, West DS, Williamson DF, Yanovski SZ. Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. N Engl J Med. 2013 Jul 11;369(2):145-54. doi: 10.1056/NEJMoa1212914. Epub 2013 Jun 24.
PMID: 23796131RESULTGolchin A, Johnson KC, Houston DK, Luchsinger JA, Beavers KM, Bertoni AG, Chen H, Wagenknecht L, Espeland MA; Action for Health in Diabetes (Look AHEAD) Aging Study Group. Associations of modifiable lifestyle and clinical factors with cognitive function in adults with type 2 diabetes. J Diabetes Complications. 2026 Jan;40(1):109227. doi: 10.1016/j.jdiacomp.2025.109227. Epub 2025 Nov 10.
PMID: 41237447DERIVEDChunawala Z, Patel KV, Garcia KR, Segar MW, Verma S, Bayes-Genis A, Pop-Busui R, Bhatt DL, Januzzi JL Jr, Butler J, Lam CSP, Bertoni AG, Espeland M, Pandey A. Cardiac Biomarkers, Intensive Lifestyle Intervention, and Heart Failure Subtypes in Diabetes: Look AHEAD Cardiac Biomarker Ancillary Study. JACC Heart Fail. 2025 Nov 6:102726. doi: 10.1016/j.jchf.2025.102726. Online ahead of print.
PMID: 41204924DERIVEDVaidya D, Yeboah-Kordieh Y, Howard M, Hugenschmidt CE, Nyquist PA, Michos ED, Kalyani RR, Yasar S, Robusto BA, Yassine HN, Clark JM, Espeland MA, Bennett WL. Sex specific associations of sex hormones with brain volumes and cerebral blood flow: A cross sectional observational study within the look AHEAD type 2 diabetes cohort. J Diabetes Complications. 2025 Oct;39(10):109161. doi: 10.1016/j.jdiacomp.2025.109161. Epub 2025 Aug 27.
PMID: 40886675DERIVEDWhitmer RA, Baker LD, Carrillo MC, Snyder HM, Cleveland ML, Gitelman DR, Kivipelto M, Leng XI, Lovato L, Papp KV, Pavlik VN, Salloway SP, Tangney CC, Farias ST, Williamson JD, Wilmoth S, Woolard N, Yu M, Espeland MA; U.S. POINTER Study Group. Baseline characteristics of the U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (U.S. POINTER): Successful enrollment of a diverse clinical trial cohort at risk for cognitive decline. Alzheimers Dement. 2025 Jun;21(6):e70351. doi: 10.1002/alz.70351.
PMID: 40556311DERIVEDVaidya D, Yeboah-Kordieh Y, Howard M, Hugenschmidt CE, Nyquist PA, Michos ED, Kalyani RR, Yasar S, Robusto BA, Yassine HN, Clark JM, Espeland MA, Bennett WL. Sex Specific Associations of Sex hormone With Brain Volumes and Cerebral Blood Flow: A Cross Sectional Observational Study Within the Look AHEAD Type 2 Diabetes Cohort. Res Sq [Preprint]. 2024 Apr 29:rs.3.rs-4254188. doi: 10.21203/rs.3.rs-4254188/v1.
PMID: 38746210DERIVEDGregg EW, Chen H, Bancks MP, Manalac R, Maruthur N, Munshi M, Wing R; Look AHEAD Research Group. Impact of remission from type 2 diabetes on long-term health outcomes: findings from the Look AHEAD study. Diabetologia. 2024 Mar;67(3):459-469. doi: 10.1007/s00125-023-06048-6. Epub 2024 Jan 18.
PMID: 38233592DERIVEDJohnson KC, Anderson A, Beavers KM, Crandall CJ, Hazuda HP, Lewis CE, Lipkin E, Schwartz AV, Pi-Sunyer FX, Zhao Q; and the Look AHEAD Research Group. The long-term effect of intentional weight loss on changes in bone mineral density in persons with type 2 diabetes: results from the Look AHEAD randomized trial. Arch Osteoporos. 2023 Jul 14;18(1):97. doi: 10.1007/s11657-023-01303-0.
PMID: 37452151DERIVEDEvans JK, Usoh CO, Simpson FR, Espinoza S, Hazuda H, Pandey A, Beckner T, Espeland MA. Long-term Impact of a 10-Year Intensive Lifestyle Intervention on a Deficit Accumulation Frailty Index: Action for Health in Diabetes Trial. J Gerontol A Biol Sci Med Sci. 2023 Oct 28;78(11):2119-2126. doi: 10.1093/gerona/glad088.
PMID: 36946420DERIVEDBancks MP, Lovato J, Balasubramanyam A, Coday M, Johnson KC, Munshi M, Rebello C, Wagenknecht LE, Espeland MA. Association of Type 2 Diabetes Subgroups With Cognitive Status Without Modification From Lifestyle Intervention. J Clin Endocrinol Metab. 2023 May 17;108(6):e334-e342. doi: 10.1210/clinem/dgac706.
PMID: 36472933DERIVEDEspeland MA, Howard M, Bennett W, Robusto BA, Yasar S, Hugenschmidt CE, Luchsinger JA, Bahnson J, Yassine H, Johnson KC, Cook D, Hayden KM; Action for Health in Diabetes (Look AHEAD) MIND Ancillary Study Group. Associations between cognitive function and endogenous levels of estradiol and testosterone in adults with type 2 diabetes. J Diabetes Complications. 2022 Sep;36(9):108268. doi: 10.1016/j.jdiacomp.2022.108268. Epub 2022 Jul 26.
PMID: 35926332DERIVEDEspeland MA, Evans JK, Carmichael O, Luchsinger JA, Marcovina SM, Neiberg R, Johnson KC, Kahn SE, Hayden KM; Action for Health in Diabetes (Look AHEAD) MIND Ancillary Study Group. Association of cognition with leptin and vascular endothelial growth factor in individuals with type 2 diabetes mellitus. Obesity (Silver Spring). 2022 Sep;30(9):1863-1874. doi: 10.1002/oby.23495. Epub 2022 Aug 3.
PMID: 35920161DERIVEDIp EH, Chen SH, Rejeski WJ, Bandeen-Roche K, Hayden KM, Hugenschmidt CE, Pierce J, Miller ME, Speiser JL, Kritchevsky SB, Houston DK, Newton RL, Rapp SR, Kitzman DW. Gradient and Acceleration of Decline in Physical and Cognitive Functions in Older Adults: A Disparity Analysis. J Gerontol A Biol Sci Med Sci. 2022 Aug 12;77(8):1603-1611. doi: 10.1093/gerona/glac109.
PMID: 35562076DERIVEDWagenknecht LE, Chao AM, Wadden TA, McCaffery JM, Hayden KM, Laferrere B, Clark JM, Johnson KC, Howard MJ, Yanovski SZ, Wing RR; Look AHEAD Research Group. Impact of COVID-19 on life experiences reported by a diverse cohort of older adults with diabetes and obesity. Obesity (Silver Spring). 2022 Jun;30(6):1268-1278. doi: 10.1002/oby.23429. Epub 2022 May 6.
PMID: 35277935DERIVEDLook AHEAD Study Group. Association Between Change in Accelerometer-Measured and Self-Reported Physical Activity and Cardiovascular Disease in the Look AHEAD Trial. Diabetes Care. 2022 Mar 1;45(3):742-749. doi: 10.2337/dc21-1206.
PMID: 35019976DERIVEDEspeland MA, Justice JN, Bahnson J, Evans JK, Munshi M, Hayden KM, Simpson FR, Johnson KC, Johnston C, Kritchevsky SR. Eight-Year Changes in Multimorbidity and Frailty in Adults With Type 2 Diabetes Mellitus: Associations With Cognitive and Physical Function and Mortality. J Gerontol A Biol Sci Med Sci. 2022 Aug 12;77(8):1691-1698. doi: 10.1093/gerona/glab342.
PMID: 34788804DERIVEDHayden KM, Neiberg RH, Evans JK, Luchsinger JA, Carmichael O, Dutton GR, Johnson KC, Kahn SE, Rapp SR, Yasar S, Espeland MA; Action for Health in Diabetes (Look AHEAD) Research Group. Legacy of a 10-Year Multidomain Lifestyle Intervention on the Cognitive Trajectories of Individuals with Overweight/Obesity and Type 2 Diabetes Mellitus. Dement Geriatr Cogn Disord. 2021;50(3):237-249. doi: 10.1159/000517160. Epub 2021 Aug 19.
PMID: 34412057DERIVEDKaze AD, Santhanam P, Erqou S, Ahima RS, Bertoni A, Echouffo-Tcheugui JB. Microvascular Disease and Incident Heart Failure Among Individuals With Type 2 Diabetes Mellitus. J Am Heart Assoc. 2021 Jun 15;10(12):e018998. doi: 10.1161/JAHA.120.018998. Epub 2021 Jun 10.
PMID: 34107742DERIVEDWing RR; Look AHEAD Research Group. Does Lifestyle Intervention Improve Health of Adults with Overweight/Obesity and Type 2 Diabetes? Findings from the Look AHEAD Randomized Trial. Obesity (Silver Spring). 2021 Aug;29(8):1246-1258. doi: 10.1002/oby.23158. Epub 2021 May 14.
PMID: 33988896DERIVEDSimpson FR, Carmichael O, Hayden KM, Hugenschmidt CE, McCaffery JM, Yasar S, Pajewski NM, Espeland MA; Indices for Accelerated Aging in Obesity and Diabetes Ancillary Study of the Action for Health in Diabetes (Look AHEAD) Trial. Does the impact of intensive lifestyle intervention on cognitive function vary depending baseline level of frailty? An ancillary study to the Action for Health in Diabetes (Look AHEAD) Trial. J Diabetes Complications. 2021 May;35(5):107909. doi: 10.1016/j.jdiacomp.2021.107909. Epub 2021 Mar 16.
PMID: 33745805DERIVEDKaze AD, Santhanam P, Musani SK, Ahima R, Echouffo-Tcheugui JB. Metabolic Dyslipidemia and Cardiovascular Outcomes in Type 2 Diabetes Mellitus: Findings From the Look AHEAD Study. J Am Heart Assoc. 2021 Apr 6;10(7):e016947. doi: 10.1161/JAHA.120.016947. Epub 2021 Mar 17.
PMID: 33728932DERIVEDBancks MP, Chen H, Balasubramanyam A, Bertoni AG, Espeland MA, Kahn SE, Pilla S, Vaughan E, Wagenknecht LE; Look AHEAD Research Group. Type 2 Diabetes Subgroups, Risk for Complications, and Differential Effects Due to an Intensive Lifestyle Intervention. Diabetes Care. 2021 May;44(5):1203-1210. doi: 10.2337/dc20-2372. Epub 2021 Mar 11.
PMID: 33707304DERIVEDQian J, Walkup MP, Chen SH, Brubaker PH, Bond DS, Richey PA, Jakicic JM, Hu K, Scheer FAJL, Middelbeek RJW; Look AHEAD Research Group. Association of Objectively Measured Timing of Physical Activity Bouts With Cardiovascular Health in Type 2 Diabetes. Diabetes Care. 2021 Apr;44(4):1046-1054. doi: 10.2337/dc20-2178. Epub 2021 Feb 17.
PMID: 33597215DERIVEDEspeland MA, Gaussoin SA, Bahnson J, Vaughan EM, Knowler WC, Simpson FR, Hazuda HP, Johnson KC, Munshi MN, Coday M, Pi-Sunyer X. Impact of an 8-Year Intensive Lifestyle Intervention on an Index of Multimorbidity. J Am Geriatr Soc. 2020 Oct;68(10):2249-2256. doi: 10.1111/jgs.16672. Epub 2020 Jul 17.
PMID: 33267558DERIVEDZhang P, Atkinson KM, Bray GA, Chen H, Clark JM, Coday M, Dutton GR, Egan C, Espeland MA, Evans M, Foreyt JP, Greenway FL, Gregg EW, Hazuda HP, Hill JO, Horton ES, Hubbard VS, Huckfeldt PJ, Jackson SD, Jakicic JM, Jeffery RW, Johnson KC, Kahn SE, Killean T, Knowler WC, Korytkowski M, Lewis CE, Maruthur NM, Michaels S, Montez MG, Nathan DM, Patricio J, Peters A, Pi-Sunyer X, Pownall H, Redmon B, Rushing JT, Steinburg H, Wadden TA, Wing RR, Wyatt H, Yanovski SZ; Look AHEAD Research Group. Within-Trial Cost-Effectiveness of a Structured Lifestyle Intervention in Adults With Overweight/Obesity and Type 2 Diabetes: Results From the Action for Health in Diabetes (Look AHEAD) Study. Diabetes Care. 2021 Jan;44(1):67-74. doi: 10.2337/dc20-0358. Epub 2020 Nov 9.
PMID: 33168654DERIVEDPatel KV, Bahnson JL, Gaussoin SA, Johnson KC, Pi-Sunyer X, White U, Olson KL, Bertoni AG, Kitzman DW, Berry JD, Pandey A; Look AHEAD Research Group. Association of Baseline and Longitudinal Changes in Body Composition Measures With Risk of Heart Failure and Myocardial Infarction in Type 2 Diabetes: Findings From the Look AHEAD Trial. Circulation. 2020 Dec 22;142(25):2420-2430. doi: 10.1161/CIRCULATIONAHA.120.050941. Epub 2020 Nov 9.
PMID: 33164570DERIVEDOlson KL, Neiberg RH, Espeland MA, Johnson KC, Knowler WC, Pi-Sunyer X, Staiano AE, Wagenknecht LE, Wing RR; Look AHEAD Research Group. Waist Circumference Change During Intensive Lifestyle Intervention and Cardiovascular Morbidity and Mortality in the Look AHEAD Trial. Obesity (Silver Spring). 2020 Oct;28(10):1902-1911. doi: 10.1002/oby.22942. Epub 2020 Sep 2.
PMID: 32881403DERIVEDLook AHEAD Research Group; Yeh HC, Bantle JP, Cassidy-Begay M, Blackburn G, Bray GA, Byers T, Clark JM, Coday M, Egan C, Espeland MA, Foreyt JP, Garcia K, Goldman V, Gregg EW, Hazuda HP, Hesson L, Hill JO, Horton ES, Jakicic JM, Jeffery RW, Johnson KC, Kahn SE, Knowler WC, Korytkowski M, Kure A, Lewis CE, Mantzoros C, Meacham M, Montez MG, Nathan DM, Pajewski N, Patricio J, Peters A, Xavier Pi-Sunyer F, Pownall H, Ryan DH, Safford M, Sedjo RL, Steinburg H, Vitolins M, Wadden TA, Wagenknecht LE, Wing RR, Wolff AC, Wyatt H, Yanovski SZ. Intensive Weight Loss Intervention and Cancer Risk in Adults with Type 2 Diabetes: Analysis of the Look AHEAD Randomized Clinical Trial. Obesity (Silver Spring). 2020 Sep;28(9):1678-1686. doi: 10.1002/oby.22936.
PMID: 32841523DERIVEDSimpson FR, Pajewski NM, Beavers KM, Kritchevsky S, McCaffery J, Nicklas BJ, Wing RR, Bertoni A, Ingram F, Ojeranti D, Espeland MA. Does the Impact of Intensive Lifestyle Intervention on Cardiovascular Disease Risk Vary According to Frailty as Measured via Deficit Accumulation? J Gerontol A Biol Sci Med Sci. 2021 Jan 18;76(2):339-345. doi: 10.1093/gerona/glaa153.
PMID: 32564066DERIVEDPandey A, Patel KV, Bahnson JL, Gaussoin SA, Martin CK, Balasubramanyam A, Johnson KC, McGuire DK, Bertoni AG, Kitzman D, Berry JD; Look AHEAD Research Group. Association of Intensive Lifestyle Intervention, Fitness, and Body Mass Index With Risk of Heart Failure in Overweight or Obese Adults With Type 2 Diabetes Mellitus: An Analysis From the Look AHEAD Trial. Circulation. 2020 Apr 21;141(16):1295-1306. doi: 10.1161/CIRCULATIONAHA.119.044865. Epub 2020 Mar 5.
PMID: 32134326DERIVEDBerger SE, Huggins GS, McCaffery JM, Jacques PF, Lichtenstein AH. Change in Cardiometabolic Risk Factors Associated With Magnitude of Weight Regain 3 Years After a 1-Year Intensive Lifestyle Intervention in Type 2 Diabetes Mellitus: The Look AHEAD Trial. J Am Heart Assoc. 2019 Oct 15;8(20):e010951. doi: 10.1161/JAHA.118.010951. Epub 2019 Oct 9.
PMID: 31594431DERIVEDSimpson FR, Pajewski NM, Nicklas B, Kritchevsky S, Bertoni A, Ingram F, Ojeranti D, Espeland MA; Indices for Accelerated Aging in Obesity and Diabetes Ancillary Study of the Action for Health in Diabetes (Look AHEAD) Trial. Impact of Multidomain Lifestyle Intervention on Frailty Through the Lens of Deficit Accumulation in Adults with Type 2 Diabetes Mellitus. J Gerontol A Biol Sci Med Sci. 2020 Sep 25;75(10):1921-1927. doi: 10.1093/gerona/glz197.
PMID: 31559418DERIVEDde Vries TI, Dorresteijn JAN, van der Graaf Y, Visseren FLJ, Westerink J. Heterogeneity of Treatment Effects From an Intensive Lifestyle Weight Loss Intervention on Cardiovascular Events in Patients With Type 2 Diabetes: Data From the Look AHEAD Trial. Diabetes Care. 2019 Oct;42(10):1988-1994. doi: 10.2337/dc19-0776. Epub 2019 Aug 15.
PMID: 31416897DERIVEDWest DS, Dutton G, Delahanty LM, Hazuda HP, Rickman AD, Knowler WC, Vitolins MZ, Neiberg RH, Peters A, Gee M, Cassidy Begay M; Look AHEAD Research Group. Weight Loss Experiences of African American, Hispanic, and Non-Hispanic White Men and Women with Type 2 Diabetes: The Look AHEAD Trial. Obesity (Silver Spring). 2019 Aug;27(8):1275-1284. doi: 10.1002/oby.22522.
PMID: 31338998DERIVEDMcDermott KD, Williams SE, Espeland MA, Erickson K, Neiberg R, Wadden TA, Bryan RN, Desiderio L, Leckie RL, Falconbridge LH, Jakicic JM, Alonso-Alonso M, Wing RR; Action for Health in Diabetes Brain Magnetic Resonance Imaging (Look AHEAD Brain) Ancillary Study Research Group. Impact of Intensive Lifestyle Intervention on Neural Food Cue Reactivity: Action for Health in Diabetes Brain Ancillary Study. Obesity (Silver Spring). 2019 Jul;27(7):1076-1084. doi: 10.1002/oby.22496. Epub 2019 May 21.
PMID: 31112370DERIVEDEspeland MA, Hayden KM, Lockhart SN, Yassine HN, Hoscheidt S, Yasar S, Luchsinger JA, Neiberg RH, Diaz Brinton R, Carmichael O. Sex-Related Differences in Brain Volumes and Cerebral Blood Flow Among Overweight and Obese Adults With Type 2 Diabetes: Exploratory Analyses From the Action for Health in Diabetes Brain Magnetic Resonance Imaging Study. J Gerontol A Biol Sci Med Sci. 2020 Mar 9;75(4):771-778. doi: 10.1093/gerona/glz090.
PMID: 30997482DERIVEDWadden TA, Chao AM, Bahnson JL, Bantle JP, Clark JM, Gaussoin SA, Jakicic JM, Johnson KC, Miller GD, Unick JL, Yanovski SZ; the Look AHEAD Research Group. End-of-Trial Health Outcomes in Look AHEAD Participants who Elected to have Bariatric Surgery. Obesity (Silver Spring). 2019 Apr;27(4):581-590. doi: 10.1002/oby.22411.
PMID: 30900413DERIVEDHazuda HP, Gaussoin SA, Wing RR, Yanovski SZ, Johnson KC, Coday M, Wadden TA, Horton ES, Van Dorsten B, Knowler WC; Look AHEAD Research Group. Long-term Association of Depression Symptoms and Antidepressant Medication Use With Incident Cardiovascular Events in the Look AHEAD (Action for Health in Diabetes) Clinical Trial of Weight Loss in Type 2 Diabetes. Diabetes Care. 2019 May;42(5):910-918. doi: 10.2337/dc18-0575. Epub 2019 Mar 4.
PMID: 30833373DERIVEDPilla SJ, Balasubramanyam A, Knowler WC, Lazo M, Nathan DM, Pi-Sunyer X, Clark JM, Maruthur NM; Look AHEAD Research Group. Islet autoantibody positivity in overweight and obese adults with type 2 diabetes. Autoimmunity. 2018 Dec;51(8):408-416. doi: 10.1080/08916934.2018.1547711. Epub 2019 Jan 2.
PMID: 30661481DERIVEDChao AM, Wadden TA, Tronieri JS, Berkowitz RI. Alcohol Intake and Weight Loss During Intensive Lifestyle Intervention for Adults with Overweight or Obesity and Diabetes. Obesity (Silver Spring). 2019 Jan;27(1):30-40. doi: 10.1002/oby.22316. Epub 2018 Nov 13.
PMID: 30421851DERIVEDEspeland MA, Carmichael O, Yasar S, Hugenschmidt C, Hazzard W, Hayden KM, Rapp SR, Neiberg R, Johnson KC, Hoscheidt S, Mielke MM; Action for Health in Diabetes (Look AHEAD) Research Group. Sex-related differences in the prevalence of cognitive impairment among overweight and obese adults with type 2 diabetes. Alzheimers Dement. 2018 Sep;14(9):1184-1192. doi: 10.1016/j.jalz.2018.05.015. Epub 2018 Jul 5.
PMID: 30201101DERIVEDMurphy CM, Rohsenow DJ, Johnson KC, Wing RR. Smoking and weight loss among smokers with overweight and obesity in Look AHEAD. Health Psychol. 2018 May;37(5):399-406. doi: 10.1037/hea0000607.
PMID: 29698015DERIVEDGregg EW, Lin J, Bardenheier B, Chen H, Rejeski WJ, Zhuo X, Hergenroeder AL, Kritchevsky SB, Peters AL, Wagenknecht LE, Ip EH, Espeland MA; Look AHEAD Study Group. Impact of Intensive Lifestyle Intervention on Disability-Free Life Expectancy: The Look AHEAD Study. Diabetes Care. 2018 May;41(5):1040-1048. doi: 10.2337/dc17-2110. Epub 2018 Mar 15.
PMID: 29545462DERIVEDPilla SJ, Yeh HC, Juraschek SP, Clark JM, Maruthur NM. Predictors of Insulin Initiation in Patients with Type 2 Diabetes: An Analysis of the Look AHEAD Randomized Trial. J Gen Intern Med. 2018 Jun;33(6):839-846. doi: 10.1007/s11606-017-4282-9. Epub 2018 Jan 19.
PMID: 29352421DERIVEDBrinkley TE, Anderson A, Soliman EZ, Bertoni AG, Greenway F, Knowler WC, Glasser SP, Horton ES, Espeland MA; Look AHEAD Research Group. Long-Term Effects of an Intensive Lifestyle Intervention on Electrocardiographic Criteria for Left Ventricular Hypertrophy: The Look AHEAD Trial. Am J Hypertens. 2018 Apr 13;31(5):541-548. doi: 10.1093/ajh/hpy004.
PMID: 29324968DERIVEDChao AM, Wadden TA, Gorin AA, Shaw Tronieri J, Pearl RL, Bakizada ZM, Yanovski SZ, Berkowitz RI. Binge Eating and Weight Loss Outcomes in Individuals with Type 2 Diabetes: 4-Year Results from the Look AHEAD Study. Obesity (Silver Spring). 2017 Nov;25(11):1830-1837. doi: 10.1002/oby.21975.
PMID: 29086498DERIVEDHouston DK, Neiberg RH, Miller ME, Hill JO, Jakicic JM, Johnson KC, Gregg EW, Hubbard VS, Pi-Sunyer X, Rejeski WJ, Wing RR, Bantle JP, Beale E, Berkowitz RI, Cassidy-Begay M, Clark JM, Coday M, Delahanty LM, Dutton G, Egan C, Foreyt JP, Greenway FL, Hazuda HP, Hergenroeder A, Horton ES, Jeffery RW, Kahn SE, Kure A, Knowler WC, Lewis CE, Martin CK, Michaels S, Montez MG, Nathan DM, Patricio J, Peters A, Pownall H, Regensteiner J, Steinburg H, Wadden TA, White K, Yanovski SZ, Zhang P, Kritchevsky SB. Physical Function Following a Long-Term Lifestyle Intervention Among Middle Aged and Older Adults With Type 2 Diabetes: The Look AHEAD Study. J Gerontol A Biol Sci Med Sci. 2018 Oct 8;73(11):1552-1559. doi: 10.1093/gerona/glx204.
PMID: 29053861DERIVEDBerger SE, Huggins GS, McCaffery JM, Lichtenstein AH. Comparison among criteria to define successful weight-loss maintainers and regainers in the Action for Health in Diabetes (Look AHEAD) and Diabetes Prevention Program trials. Am J Clin Nutr. 2017 Dec;106(6):1337-1346. doi: 10.3945/ajcn.117.157446. Epub 2017 Oct 18.
PMID: 29046304DERIVEDEspeland MA, Carmichael O, Hayden K, Neiberg RH, Newman AB, Keller JN, Wadden TA, Rapp SR, Hill JO, Horton ES, Johnson KC, Wagenknecht L, Wing RR; Action for Health In Diabetes Brain Magnetic Resonance Imaging (Look AHEAD Brain) and Action for Health Movement and Memory Ancillary Study Research Groups. Long-term Impact of Weight Loss Intervention on Changes in Cognitive Function: Exploratory Analyses from the Action for Health in Diabetes Randomized Controlled Clinical Trial. J Gerontol A Biol Sci Med Sci. 2018 Mar 14;73(4):484-491. doi: 10.1093/gerona/glx165.
PMID: 28958022DERIVEDUnick JL, Gaussoin SA, Hill JO, Jakicic JM, Bond DS, Hellgren M, Johnson KC, Peters AL, Coday M, Kitzman DW, Bossart S, Wing RR; Look AHEAD Research Group.. Objectively Assessed Physical Activity and Weight Loss Maintenance among Individuals Enrolled in a Lifestyle Intervention. Obesity (Silver Spring). 2017 Nov;25(11):1903-1909. doi: 10.1002/oby.21971. Epub 2017 Sep 20.
PMID: 28940967DERIVEDEspeland MA, Luchsinger JA, Baker LD, Neiberg R, Kahn SE, Arnold SE, Wing RR, Blackburn GL, Bray G, Evans M, Hazuda HP, Jeffery RW, Wilson VM, Clark JM, Coday M, Demos-McDermott K, Foreyt JP, Greenway F, Hill JO, Horton ES, Jakicic JM, Johnson KC, Knowler WC, Lewis CE, Nathan DM, Peters A, Pi-Sunyer X, Pownall H, Wadden TA, Rapp SR; Look AHEAD Study Group. Effect of a long-term intensive lifestyle intervention on prevalence of cognitive impairment. Neurology. 2017 May 23;88(21):2026-2035. doi: 10.1212/WNL.0000000000003955. Epub 2017 Apr 26.
PMID: 28446656DERIVEDLook AHEAD Research Group. Effects of a long-term lifestyle modification programme on peripheral neuropathy in overweight or obese adults with type 2 diabetes: the Look AHEAD study. Diabetologia. 2017 Jun;60(6):980-988. doi: 10.1007/s00125-017-4253-z. Epub 2017 Mar 27.
PMID: 28349174DERIVEDRapp SR, Luchsinger JA, Baker LD, Blackburn GL, Hazuda HP, Demos-McDermott KE, Jeffery RW, Keller JN, McCaffery JM, Pajewski NM, Evans M, Wadden TA, Arnold SE, Espeland MA; Look AHEAD Research Group. Effect of a Long-Term Intensive Lifestyle Intervention on Cognitive Function: Action for Health in Diabetes Study. J Am Geriatr Soc. 2017 May;65(5):966-972. doi: 10.1111/jgs.14692. Epub 2017 Jan 9.
PMID: 28067945DERIVEDBeavers KM, Leng I, Rapp SR, Miller ME, Houston DK, Marsh AP, Hire DG, Baker LD, Bray GA, Blackburn GL, Hergenroeder AL, Jakicic JM, Johnson KC, Korytkowski MT, Dorsten BV, Kritchevsky SB; Action for Health in Diabetes Movement and Memory Ancillary Study Research Group. Effects of Longitudinal Glucose Exposure on Cognitive and Physical Function: Results from the Action for Health in Diabetes Movement and Memory Study. J Am Geriatr Soc. 2017 Jan;65(1):137-145. doi: 10.1111/jgs.14478. Epub 2016 Sep 27.
PMID: 27676466DERIVEDLook AHEAD Research Group; Gregg EW, Jakicic JM, Blackburn G, Bloomquist P, Bray GA, Clark JM, Coday M, Curtis JM, Egan C, Evans M, Foreyt J, Foster G, Hazuda HP, Hill JO, Horton ES, Hubbard VS, Jeffery RW, Johnson KC, Kitabchi AE, Knowler WC, Kriska A, Lang W, Lewis CE, Montez MG, Nathan DM, Neiberg RH, Patricio J, Peters A, Pi-Sunyer X, Pownall H, Redmon B, Regensteiner J, Rejeski J, Ribisl PM, Safford M, Stewart K, Trence D, Wadden TA, Wing RR, Yanovski SZ. Association of the magnitude of weight loss and changes in physical fitness with long-term cardiovascular disease outcomes in overweight or obese people with type 2 diabetes: a post-hoc analysis of the Look AHEAD randomised clinical trial. Lancet Diabetes Endocrinol. 2016 Nov;4(11):913-921. doi: 10.1016/S2213-8587(16)30162-0. Epub 2016 Aug 30.
PMID: 27595918DERIVEDPownall HJ, Schwartz AV, Bray GA, Berkowitz RI, Lewis CE, Boyko EJ, Jakicic JM, Chen H, Heshka S, Gregg EW, Johnson KC; Look AHEAD Research Group. Changes in regional body composition over 8 years in a randomized lifestyle trial: The look AHEAD study. Obesity (Silver Spring). 2016 Sep;24(9):1899-905. doi: 10.1002/oby.21577. Epub 2016 Jul 28.
PMID: 27465756DERIVEDEspeland MA, Erickson K, Neiberg RH, Jakicic JM, Wadden TA, Wing RR, Desiderio L, Erus G, Hsieh MK, Davatzikos C, Maschak-Carey BJ, Laurienti PJ, Demos-McDermott K, Bryan RN; Action for Health in Diabetes Brain Magnetic Resonance Imaging (Look AHEAD Brain) Ancillary Study Research Group. Brain and White Matter Hyperintensity Volumes After 10 Years of Random Assignment to Lifestyle Intervention. Diabetes Care. 2016 May;39(5):764-71. doi: 10.2337/dc15-2230. Epub 2016 Mar 29.
PMID: 27208378DERIVEDZhang P, Hire D, Espeland MA, Knowler WC, Thomas S, Tsai AG, Glick HA; Look AHEAD Research Group. Impact of intensive lifestyle intervention on preference-based quality of life in type 2 diabetes: Results from the Look AHEAD trial. Obesity (Silver Spring). 2016 Apr;24(4):856-64. doi: 10.1002/oby.21445. Epub 2016 Mar 8.
PMID: 27028282DERIVEDLook AHEAD Research Group. Prospective Association of GLUL rs10911021 With Cardiovascular Morbidity and Mortality Among Individuals With Type 2 Diabetes: The Look AHEAD Study. Diabetes. 2016 Jan;65(1):297-302. doi: 10.2337/db15-0890. Epub 2015 Sep 22.
PMID: 26395743DERIVEDAlonso A, Bahnson JL, Gaussoin SA, Bertoni AG, Johnson KC, Lewis CE, Vetter M, Mantzoros CS, Jeffery RW, Soliman EZ; Look AHEAD Research Group. Effect of an intensive lifestyle intervention on atrial fibrillation risk in individuals with type 2 diabetes: the Look AHEAD randomized trial. Am Heart J. 2015 Oct;170(4):770-777.e5. doi: 10.1016/j.ahj.2015.07.026. Epub 2015 Jul 26.
PMID: 26386801DERIVEDPapandonatos GD, Pan Q, Pajewski NM, Delahanty LM, Peter I, Erar B, Ahmad S, Harden M, Chen L, Fontanillas P; GIANT Consortium; Wagenknecht LE, Kahn SE, Wing RR, Jablonski KA, Huggins GS, Knowler WC, Florez JC, McCaffery JM, Franks PW; Diabetes Prevention Program and the Look AHEAD Research Groups. Genetic Predisposition to Weight Loss and Regain With Lifestyle Intervention: Analyses From the Diabetes Prevention Program and the Look AHEAD Randomized Controlled Trials. Diabetes. 2015 Dec;64(12):4312-21. doi: 10.2337/db15-0441. Epub 2015 Aug 7.
PMID: 26253612DERIVEDBelalcazar LM, Lang W, Haffner SM, Schwenke DC, Kriska A, Balasubramanyam A, Hoogeveen RC, Pi-Sunyer FX, Tracy RP, Ballantyne CM; Look AHEAD (Action for Health in Diabetes) Research Group. Improving Adiponectin Levels in Individuals With Diabetes and Obesity: Insights From Look AHEAD. Diabetes Care. 2015 Aug;38(8):1544-50. doi: 10.2337/dc14-2775. Epub 2015 May 13.
PMID: 25972574DERIVEDLook AHEAD Research Group. Prospective association of a genetic risk score and lifestyle intervention with cardiovascular morbidity and mortality among individuals with type 2 diabetes: the Look AHEAD randomised controlled trial. Diabetologia. 2015 Aug;58(8):1803-13. doi: 10.1007/s00125-015-3610-z. Epub 2015 May 14.
PMID: 25972230DERIVEDBelalcazar LM, Papandonatos GD, McCaffery JM, Peter I, Pajewski NM, Erar B, Allred ND, Balasubramanyam A, Bowden DW, Brautbar A, Pi-Sunyer FX, Ballantyne CM, Huggins GS; Look AHEAD Research Group. A common variant in the CLDN7/ELP5 locus predicts adiponectin change with lifestyle intervention and improved fitness in obese individuals with diabetes. Physiol Genomics. 2015 Jun;47(6):215-24. doi: 10.1152/physiolgenomics.00109.2014. Epub 2015 Mar 10.
PMID: 25759378DERIVEDPownall HJ, Bray GA, Wagenknecht LE, Walkup MP, Heshka S, Hubbard VS, Hill J, Kahn SE, Nathan DM, Schwartz AV, Johnson KC; Look AHEAD Research Group. Changes in body composition over 8 years in a randomized trial of a lifestyle intervention: the look AHEAD study. Obesity (Silver Spring). 2015 Mar;23(3):565-72. doi: 10.1002/oby.21005.
PMID: 25707379DERIVEDWhite DK, Neogi T, Rejeski WJ, Walkup MP, Lewis CE, Nevitt MC, Foy CG, Felson DT; Look AHEAD Research Group. Can an intensive diet and exercise program prevent knee pain among overweight adults at high risk? Arthritis Care Res (Hoboken). 2015 Jul;67(7):965-71. doi: 10.1002/acr.22544.
PMID: 25692781DERIVEDEspeland MA, Probstfield J, Hire D, Redmon JB, Evans GW, Coday M, Lewis CE, Johnson KC, Wilmoth S, Bahnson J, Dulin MF, Green JB, Knowler WC, Kitabchi A, Murillo AL, Osei K, Rehman SU, Cushman WC; Look AHEAD Research Group; ACCORD Study Group. Systolic Blood Pressure Control Among Individuals With Type 2 Diabetes: A Comparative Effectiveness Analysis of Three Interventions. Am J Hypertens. 2015 Aug;28(8):995-1009. doi: 10.1093/ajh/hpu292. Epub 2015 Feb 9.
PMID: 25666468DERIVEDEspeland MA, Beavers KM, Gibbs BB, Johnson KC, Hughes TM, Baker LD, Jakicic J, Korytkowski M, Miller M, Bray GA. Ankle-brachial index and inter-artery blood pressure differences as predictors of cognitive function in overweight and obese older adults with diabetes: results from the Action for Health in Diabetes movement and memory study. Int J Geriatr Psychiatry. 2015 Oct;30(10):999-1007. doi: 10.1002/gps.4253. Epub 2014 Dec 26.
PMID: 25546032DERIVEDLook AHEAD Research Group. Effect of a long-term behavioural weight loss intervention on nephropathy in overweight or obese adults with type 2 diabetes: a secondary analysis of the Look AHEAD randomised clinical trial. Lancet Diabetes Endocrinol. 2014 Oct;2(10):801-9. doi: 10.1016/S2213-8587(14)70156-1. Epub 2014 Aug 10.
PMID: 25127483DERIVEDLipkin EW, Schwartz AV, Anderson AM, Davis C, Johnson KC, Gregg EW, Bray GA, Berkowitz R, Peters AL, Hodges A, Lewis C, Kahn SE; Look AHEAD Research Group. The Look AHEAD Trial: bone loss at 4-year follow-up in type 2 diabetes. Diabetes Care. 2014 Oct;37(10):2822-9. doi: 10.2337/dc14-0762. Epub 2014 Jul 21.
PMID: 25048381DERIVEDRubin RR, Wadden TA, Bahnson JL, Blackburn GL, Brancati FL, Bray GA, Coday M, Crow SJ, Curtis JM, Dutton G, Egan C, Evans M, Ewing L, Faulconbridge L, Foreyt J, Gaussoin SA, Gregg EW, Hazuda HP, Hill JO, Horton ES, Hubbard VS, Jakicic JM, Jeffery RW, Johnson KC, Kahn SE, Knowler WC, Lang W, Lewis CE, Montez MG, Murillo A, Nathan DM, Patricio J, Peters A, Pi-Sunyer X, Pownall H, Rejeski WJ, Rosenthal RH, Ruelas V, Toledo K, Van Dorsten B, Vitolins M, Williamson D, Wing RR, Yanovski SZ, Zhang P; Look AHEAD Research Group. Impact of intensive lifestyle intervention on depression and health-related quality of life in type 2 diabetes: the Look AHEAD Trial. Diabetes Care. 2014 Jun;37(6):1544-53. doi: 10.2337/dc13-1928.
PMID: 24855155DERIVEDUnick JL, Hogan PE, Neiberg RH, Cheskin LJ, Dutton GR, Evans-Hudnall G, Jeffery R, Kitabchi AE, Nelson JA, Pi-Sunyer FX, West DS, Wing RR; Look AHEAD Research Group. Evaluation of early weight loss thresholds for identifying nonresponders to an intensive lifestyle intervention. Obesity (Silver Spring). 2014 Jul;22(7):1608-16. doi: 10.1002/oby.20777. Epub 2014 Apr 28.
PMID: 24771618DERIVEDLook AHEAD Research Group. Eight-year weight losses with an intensive lifestyle intervention: the look AHEAD study. Obesity (Silver Spring). 2014 Jan;22(1):5-13. doi: 10.1002/oby.20662.
PMID: 24307184DERIVEDMcCaffery JM, Papandonatos GD, Huggins GS, Peter I, Erar B, Kahn SE, Knowler WC, Lipkin EW, Kitabchi AE, Wagenknecht LE, Wing RR; Genetic Subgroup of Look AHEAD; Look AHEAD Research Group. Human cardiovascular disease IBC chip-wide association with weight loss and weight regain in the look AHEAD trial. Hum Hered. 2013;75(2-4):160-74. doi: 10.1159/000353181. Epub 2013 Sep 27.
PMID: 24081232DERIVEDWing RR, Bond DS, Gendrano IN 3rd, Wadden T, Bahnson J, Lewis CE, Brancati F, Schneider S, Kitabchi AE, Van Dorsten B, Rosen RC; Sexual Dysfunction Subgroup of the Look AHEAD Research Group. Effect of intensive lifestyle intervention on sexual dysfunction in women with type 2 diabetes: results from an ancillary Look AHEAD study. Diabetes Care. 2013 Oct;36(10):2937-44. doi: 10.2337/dc13-0315. Epub 2013 Jun 11.
PMID: 23757437DERIVEDSchwenke DC, Foreyt JP, Miller ER 3rd, Reeves RS, Vitolins MZ; Oxidative Stress Subgroup of the Look AHEAD Research Group. Plasma concentrations of trans fatty acids in persons with type 2 diabetes between September 2002 and April 2004. Am J Clin Nutr. 2013 Apr;97(4):862-71. doi: 10.3945/ajcn.112.046508. Epub 2013 Feb 27.
PMID: 23446895DERIVEDUnick JL, Beavers D, Bond DS, Clark JM, Jakicic JM, Kitabchi AE, Knowler WC, Wadden TA, Wagenknecht LE, Wing RR; Look AHEAD Research Group. The long-term effectiveness of a lifestyle intervention in severely obese individuals. Am J Med. 2013 Mar;126(3):236-42, 242.e1-2. doi: 10.1016/j.amjmed.2012.10.010.
PMID: 23410564DERIVEDRubin RR, Peyrot M, Gaussoin SA, Espeland MA, Williamson D, Faulconbridge LF, Wadden TA, Ewing L, Safford M, Evans-Hudnall G, Wing RR, Knowler WC; Look AHEAD Research Group. Four-year analysis of cardiovascular disease risk factors, depression symptoms, and antidepressant medicine use in the Look AHEAD (Action for Health in Diabetes) clinical trial of weight loss in diabetes. Diabetes Care. 2013 May;36(5):1088-94. doi: 10.2337/dc12-1871. Epub 2013 Jan 28.
PMID: 23359362DERIVEDGregg EW, Chen H, Wagenknecht LE, Clark JM, Delahanty LM, Bantle J, Pownall HJ, Johnson KC, Safford MM, Kitabchi AE, Pi-Sunyer FX, Wing RR, Bertoni AG; Look AHEAD Research Group. Association of an intensive lifestyle intervention with remission of type 2 diabetes. JAMA. 2012 Dec 19;308(23):2489-96. doi: 10.1001/jama.2012.67929.
PMID: 23288372DERIVEDJakicic JM, Egan CM, Fabricatore AN, Gaussoin SA, Glasser SP, Hesson LA, Knowler WC, Lang W, Regensteiner JG, Ribisl PM, Ryan DH; Look AHEAD Research Group. Four-year change in cardiorespiratory fitness and influence on glycemic control in adults with type 2 diabetes in a randomized trial: the Look AHEAD Trial. Diabetes Care. 2013 May;36(5):1297-303. doi: 10.2337/dc12-0712. Epub 2012 Dec 6.
PMID: 23223405DERIVEDGibbs BB, Brancati FL, Chen H, Coday M, Jakicic JM, Lewis CE, Stewart KJ, Clark JM; (for the Look AHEAD Research Group). Effect of improved fitness beyond weight loss on cardiovascular risk factors in individuals with type 2 diabetes in the Look AHEAD study. Eur J Prev Cardiol. 2014 May;21(5):608-17. doi: 10.1177/2047487312462823. Epub 2012 Sep 25.
PMID: 23012688DERIVEDMcCaffery JM, Papandonatos GD, Peter I, Huggins GS, Raynor HA, Delahanty LM, Cheskin LJ, Balasubramanyam A, Wagenknecht LE, Wing RR; Genetic Subgroup of Look AHEAD; Look AHEAD Research Group. Obesity susceptibility loci and dietary intake in the Look AHEAD Trial. Am J Clin Nutr. 2012 Jun;95(6):1477-86. doi: 10.3945/ajcn.111.026955. Epub 2012 Apr 18.
PMID: 22513296DERIVEDRejeski WJ, Ip EH, Bertoni AG, Bray GA, Evans G, Gregg EW, Zhang Q; Look AHEAD Research Group. Lifestyle change and mobility in obese adults with type 2 diabetes. N Engl J Med. 2012 Mar 29;366(13):1209-17. doi: 10.1056/NEJMoa1110294.
PMID: 22455415DERIVEDSchwartz AV, Johnson KC, Kahn SE, Shepherd JA, Nevitt MC, Peters AL, Walkup MP, Hodges A, Williams CC, Bray GA; Look AHEAD Research Group. Effect of 1 year of an intentional weight loss intervention on bone mineral density in type 2 diabetes: results from the Look AHEAD randomized trial. J Bone Miner Res. 2012 Mar;27(3):619-27. doi: 10.1002/jbmr.1483.
PMID: 22354851DERIVEDBrancati FL, Evans M, Furberg CD, Geller N, Haffner S, Kahn SE, Kaufmann PG, Lewis CE, Nathan DM, Pitt B, Safford MM; Look AHEAD Study Group. Midcourse correction to a clinical trial when the event rate is underestimated: the Look AHEAD (Action for Health in Diabetes) Study. Clin Trials. 2012 Feb;9(1):113-24. doi: 10.1177/1740774511432726.
PMID: 22334468DERIVEDPhelan S, Kanaya AM, Subak LL, Hogan PE, Espeland MA, Wing RR, Burgio KL, DiLillo V, Gorin AA, West DS, Brown JS; Look AHEAD Research Group. Weight loss prevents urinary incontinence in women with type 2 diabetes: results from the Look AHEAD trial. J Urol. 2012 Mar;187(3):939-44. doi: 10.1016/j.juro.2011.10.139. Epub 2012 Jan 20.
PMID: 22264468DERIVEDMount DL, Davis C, Kennedy B, Raatz S, Dotson K, Gary-Webb TL, Thomas S, Johnson KC, Espeland MA; Look AHEAD Research Group. Factors influencing enrollment of African Americans in the Look AHEAD trial. Clin Trials. 2012 Feb;9(1):80-9. doi: 10.1177/1740774511427929. Epub 2011 Nov 7.
PMID: 22064686DERIVEDBertoni AG, Wagenknecht LE, Kitzman DW, Marcovina SM, Rushing JT, Espeland MA; Brain Natriuretic Peptide Subgroup of the Look AHEAD Research Group. Impact of the look AHEAD intervention on NT-pro brain natriuretic peptide in overweight and obese adults with diabetes. Obesity (Silver Spring). 2012 Jul;20(7):1511-8. doi: 10.1038/oby.2011.296. Epub 2011 Sep 29.
PMID: 21959345DERIVEDUnick JL, Beavers D, Jakicic JM, Kitabchi AE, Knowler WC, Wadden TA, Wing RR; Look AHEAD Research Group. Effectiveness of lifestyle interventions for individuals with severe obesity and type 2 diabetes: results from the Look AHEAD trial. Diabetes Care. 2011 Oct;34(10):2152-7. doi: 10.2337/dc11-0874. Epub 2011 Aug 11.
PMID: 21836103DERIVEDWesche-Thobaben JA. The development and description of the comparison group in the Look AHEAD trial. Clin Trials. 2011 Jun;8(3):320-9. doi: 10.1177/1740774511405858.
PMID: 21730080DERIVEDWing RR, Lang W, Wadden TA, Safford M, Knowler WC, Bertoni AG, Hill JO, Brancati FL, Peters A, Wagenknecht L; Look AHEAD Research Group. Benefits of modest weight loss in improving cardiovascular risk factors in overweight and obese individuals with type 2 diabetes. Diabetes Care. 2011 Jul;34(7):1481-6. doi: 10.2337/dc10-2415. Epub 2011 May 18.
PMID: 21593294DERIVEDBelalcazar LM, Ballantyne CM, Lang W, Haffner SM, Rushing J, Schwenke DC, Pi-Sunyer FX, Tracy RP; Look Action for Health in Diabetes Research Group. Metabolic factors, adipose tissue, and plasminogen activator inhibitor-1 levels in type 2 diabetes: findings from the look AHEAD study. Arterioscler Thromb Vasc Biol. 2011 Jul;31(7):1689-95. doi: 10.1161/ATVBAHA.111.224386. Epub 2011 Apr 21.
PMID: 21512162DERIVEDLook AHEAD Research Group; Wing RR. Long-term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus: four-year results of the Look AHEAD trial. Arch Intern Med. 2010 Sep 27;170(17):1566-75. doi: 10.1001/archinternmed.2010.334.
PMID: 20876408DERIVEDBelalcazar LM, Reboussin DM, Haffner SM, Hoogeveen RC, Kriska AM, Schwenke DC, Tracy RP, Pi-Sunyer FX, Ballantyne CM; Look AHEAD Research Group. A 1-year lifestyle intervention for weight loss in individuals with type 2 diabetes reduces high C-reactive protein levels and identifies metabolic predictors of change: from the Look AHEAD (Action for Health in Diabetes) study. Diabetes Care. 2010 Nov;33(11):2297-303. doi: 10.2337/dc10-0728. Epub 2010 Aug 3.
PMID: 20682679DERIVEDRubin RR, Gaussoin SA, Peyrot M, DiLillo V, Miller K, Wadden TA, West DS, Wing RR, Knowler WC; Look AHEAD Research Group. Cardiovascular disease risk factors, depression symptoms and antidepressant medicine use in the Look AHEAD (Action for Health in Diabetes) clinical trial of weight loss in diabetes. Diabetologia. 2010 Aug;53(8):1581-9. doi: 10.1007/s00125-010-1765-1. Epub 2010 Apr 28.
PMID: 20422396DERIVEDJakicic JM, Gregg E, Knowler W, Kelley DE, Lang W, Miller GD, Pi-Sunyer FX, Regensteiner JG, Rejeski WJ, Ridisl P, Walkup MP, Wolf DL. Activity patterns of obese adults with type 2 diabetes in the look AHEAD study. Med Sci Sports Exerc. 2010 Nov;42(11):1995-2005. doi: 10.1249/MSS.0b013e3181e054f0.
PMID: 20386337DERIVEDRedmon JB, Bertoni AG, Connelly S, Feeney PA, Glasser SP, Glick H, Greenway F, Hesson LA, Lawlor MS, Montez M, Montgomery B; Look AHEAD Research Group. Effect of the look AHEAD study intervention on medication use and related cost to treat cardiovascular disease risk factors in individuals with type 2 diabetes. Diabetes Care. 2010 Jun;33(6):1153-8. doi: 10.2337/dc09-2090. Epub 2010 Mar 23.
PMID: 20332353DERIVEDBelalcazar LM, Reboussin DM, Haffner SM, Reeves RS, Schwenke DC, Hoogeveen RC, Pi-Sunyer FX, Ballantyne CM; Look AHEAD (Action for Health in Diabetes) Obesity, Inflammation, and Thrombosis Research Group. Marine omega-3 fatty acid intake: associations with cardiometabolic risk and response to weight loss intervention in the Look AHEAD (Action for Health in Diabetes) study. Diabetes Care. 2010 Jan;33(1):197-9. doi: 10.2337/dc09-1235. Epub 2009 Oct 19.
PMID: 19841042DERIVEDWilliamson DA, Rejeski J, Lang W, Van Dorsten B, Fabricatore AN, Toledo K; Look AHEAD Research Group. Impact of a weight management program on health-related quality of life in overweight adults with type 2 diabetes. Arch Intern Med. 2009 Jan 26;169(2):163-71. doi: 10.1001/archinternmed.2008.544.
PMID: 19171813DERIVEDGorin AA, Niemeier HM, Hogan P, Coday M, Davis C, DiLillo VG, Gluck ME, Wadden TA, West DS, Williamson D, Yanovski SZ; Look AHEAD Research Group. Binge eating and weight loss outcomes in overweight and obese individuals with type 2 diabetes: results from the Look AHEAD trial. Arch Gen Psychiatry. 2008 Dec;65(12):1447-55. doi: 10.1001/archpsyc.65.12.1447.
PMID: 19047532DERIVEDEspeland MA, Regensteiner JG, Jaramillo SA, Gregg E, Knowler WC, Wagenknecht LE, Bahnson J, Haffner S, Hill J, Hiatt WR; Look AHEAD Study Group. Measurement characteristics of the ankle-brachial index: results from the Action for Health in Diabetes study. Vasc Med. 2008 Aug;13(3):225-33. doi: 10.1177/1358863X08091338.
PMID: 18687759DERIVEDRaynor HA, Jeffery RW, Ruggiero AM, Clark JM, Delahanty LM; Look AHEAD (Action for Health in Diabetes) Research Group. Weight loss strategies associated with BMI in overweight adults with type 2 diabetes at entry into the Look AHEAD (Action for Health in Diabetes) trial. Diabetes Care. 2008 Jul;31(7):1299-304. doi: 10.2337/dc07-2295. Epub 2008 Mar 28.
PMID: 18375417DERIVEDRibisl PM, Lang W, Jaramillo SA, Jakicic JM, Stewart KJ, Bahnson J, Bright R, Curtis JF, Crow RS, Soberman JE; Look AHEAD Research Group. Exercise capacity and cardiovascular/metabolic characteristics of overweight and obese individuals with type 2 diabetes: the Look AHEAD clinical trial. Diabetes Care. 2007 Oct;30(10):2679-84. doi: 10.2337/dc06-2487. Epub 2007 Jul 20.
PMID: 17644623DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Results Point of Contact
- Title
- Dr. Mark Espeland, Principal Investigator
- Organization
- Wake Forest School of Medicine
Study Officials
- PRINCIPAL INVESTIGATOR
Mark A Espeland, PhD
Wake Forest University Health Sciences
Publication Agreements
- PI is Sponsor Employee
- No
- Restrictive Agreement
- No
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 21, 2001
First Posted
June 21, 2001
Study Start
June 1, 2001
Primary Completion
September 1, 2012
Study Completion
June 30, 2020
Last Updated
August 2, 2023
Results First Posted
August 2, 2023
Record last verified: 2023-05
Data Sharing
- IPD Sharing
- Will share
- Shared Documents
- STUDY PROTOCOL, SAP, CSR
- Time Frame
- Within one year of each phase of the study
- Access Criteria
- Publicly available / De-identified
We plan to share data sets through the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) repository, baseline data sets are currently available. Outcome data will be available approximately 1 year after the study is over.