NCT00011440

Brief Summary

This study is designed to investigate whether exposure to particulate air pollution increases the allergic response to allergens. Research studies suggest that symptoms in individuals with allergies may be aggravated by exposure to particulate air pollution. We sought to experimental determine this by exposing human volunteers to combustion particles, a component of air pollution, and then challenge them with an allergen such as ragweed or oak tree pollen. Using biological tests we can measure whether the allergen response is magnified by prior particulate exposure.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
20

participants targeted

Target at below P25 for all trials

Timeline
Completed

Started Dec 1998

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 1, 1998

Completed
2.2 years until next milestone

First Submitted

Initial submission to the registry

February 20, 2001

Completed
1 day until next milestone

First Posted

Study publicly available on registry

February 21, 2001

Completed
1.4 years until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2002

Completed
Last Updated

March 23, 2006

Status Verified

March 1, 2006

First QC Date

February 20, 2001

Last Update Submit

March 22, 2006

Conditions

Allergic RhinitisAllergy

Keywords

AllergyAir pollutionLung functionInflammation

Eligibility Criteria

Age18 Years - 60 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)
Adult without a history of asthma or respiratory disease.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Study Sites (1)

Harvard School of Public Health

Boston, Massachusetts, 02115, United States

Location

MeSH Terms

Conditions

Rhinitis, AllergicHypersensitivityInflammation

Condition Hierarchy (Ancestors)

RhinitisNose DiseasesRespiratory Tract DiseasesRespiratory HypersensitivityOtorhinolaryngologic DiseasesHypersensitivity, ImmediateImmune System DiseasesPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Design

Study Type
observational
Observational Model
NATURAL HISTORY
Time Perspective
PROSPECTIVE
Sponsor Type
NIH

Study Record Dates

First Submitted

February 20, 2001

First Posted

February 21, 2001

Study Start

December 1, 1998

Study Completion

August 1, 2002

Last Updated

March 23, 2006

Record last verified: 2006-03

Locations

US(1)