NCT00007046

Brief Summary

OBJECTIVES: I. Identify and characterize the gene causing diaphyseal medullary stenosis with malignant fibrous histiocytoma of the bone. II. Determine the clinical manifestations of this disease in these patients.

Trial Health

80
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 1, 2000

Completed
4 months until next milestone

First Submitted

Initial submission to the registry

December 6, 2000

Completed
1 day until next milestone

First Posted

Study publicly available on registry

December 7, 2000

Completed
Last Updated

June 24, 2005

Status Verified

December 1, 2003

First QC Date

December 6, 2000

Last Update Submit

June 23, 2005

Conditions

StenosisHistiocytoma

Keywords

arthritis & connective tissue diseasesbone cancerdiaphyseal medullary stenosisgenetic diseases and dysmorphic syndromesmalignant fibrous histiocytoma of bonemusculoskeletal/mesodermal canceroncologic disordersrare disease

Eligibility Criteria

Age0 Years - 90 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
PROTOCOL ENTRY CRITERIA: --Disease Characteristics-- Diagnosis of diaphyseal medullary stenosis with malignant fibrous histiocytoma of the bone OR Family member, including spouses, of an affected individual --Patient Characteristics-- Renal: Not specified * Not pregnant * Negative pregnancy test * No diminished mental capacity * No prisoners

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Study Sites (1)

Mount Sinai School of Medicine

New York, New York, 10029, United States

Location

MeSH Terms

Conditions

Constriction, PathologicHistiocytomaArthritisConnective Tissue DiseasesBone NeoplasmsGenetic Diseases, InbornHistiocytoma, Malignant FibrousRare Diseases

Condition Hierarchy (Ancestors)

Pathological Conditions, AnatomicalPathological Conditions, Signs and SymptomsNeoplasms, Fibrous TissueNeoplasms, Connective TissueNeoplasms, Connective and Soft TissueNeoplasms by Histologic TypeNeoplasmsJoint DiseasesMusculoskeletal DiseasesSkin and Connective Tissue DiseasesNeoplasms by SiteBone DiseasesCongenital, Hereditary, and Neonatal Diseases and AbnormalitiesSarcomaDisease AttributesPathologic Processes

Study Officials

  • J.A. Martignetti

    Icahn School of Medicine at Mount Sinai

    STUDY CHAIR

Study Design

Study Type
observational
Sponsor Type
NIH

Study Record Dates

First Submitted

December 6, 2000

First Posted

December 7, 2000

Study Start

August 1, 2000

Last Updated

June 24, 2005

Record last verified: 2003-12

Locations

US(1)