Clinical Trials of Two Non-drug Treatments for Chronic Depression
Light and Negative Ion Treatment for Chronic Depression
2 other identifiers
interventional
32
1 country
2
Brief Summary
This study investigates the potential efficacy of two nonpharmacologic treatments for nonseasonal depression, bright light exposure or high-density negative air ion exposure. Treatments are self-administered at home by the patient under close clinical supervision.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Apr 2000
Longer than P75 for not_applicable
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 1, 2000
CompletedFirst Submitted
Initial submission to the registry
August 11, 2000
CompletedFirst Posted
Study publicly available on registry
August 14, 2000
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 1, 2003
CompletedStudy Completion
Last participant's last visit for all outcomes
February 1, 2004
CompletedOctober 1, 2014
March 1, 2008
3.2 years
August 11, 2000
September 30, 2014
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Depression scale score
change in score relative to baseline
5 weeks
Secondary Outcomes (1)
pineal melatonin onset tme
5 weeks
Study Arms (3)
bright light box
ACTIVE COMPARATOR60 min light therapy shortly after awakening
high-output negative ion generator
ACTIVE COMPARATOR60 min high-density exposure shortly after awakening
low-output negative ion generator
PLACEBO COMPARATOR60 min low-density exposure shortly after awakening
Interventions
60-min high-density ion exposure shortly after awakening
60-min low-density ion exposure shortly after awakening
Eligibility Criteria
You may qualify if:
- Diagnosis of major depression
- Must be able to maintain a regular sleep schedule
You may not qualify if:
- Depression restricted to certain seasons of the year
- Presence of other psychiatric disorders
- Current use of psychotropic medication, except for selective serotonin reuptake inhibitors (SSRIs)
- Current use of recreational drugs or supplements that may affect mood
- Current medical illness or medication that may affect response to antidepressant treatment
- Long-distance travel while participating in the program
- Pregnancy
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
Department of Psychology, Wesleyan University
Middletown, Connecticut, 06459, United States
Columbia Presbyterian Medical Center
New York, New York, 10032, United States
Related Publications (2)
Terman M, Terman JS, Ross DC. A controlled trial of timed bright light and negative air ionization for treatment of winter depression. Arch Gen Psychiatry. 1998 Oct;55(10):875-82. doi: 10.1001/archpsyc.55.10.875.
PMID: 9783557BACKGROUNDKripke DF. Light treatment for nonseasonal depression: speed, efficacy, and combined treatment. J Affect Disord. 1998 May;49(2):109-17. doi: 10.1016/s0165-0327(98)00005-6.
PMID: 9609674BACKGROUND
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Michael Terman
NYS Psuchiatric Institute
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
August 11, 2000
First Posted
August 14, 2000
Study Start
April 1, 2000
Primary Completion
July 1, 2003
Study Completion
February 1, 2004
Last Updated
October 1, 2014
Record last verified: 2008-03