Does Islet Transplantation Eliminate Hypoglycemia?
2 other identifiers
interventional
N/A
0 countries
N/A
Brief Summary
Low blood sugar (hypoglycemia) is a recurrent problem for many people with diabetes. Successful transplantation of clusters (islets) of normal cells, that include those which produce the sugar-lowering hormone insulin, from the pancreas of a person who did not have diabetes into a person with diabetes should eliminate high blood sugar levels. We wish to determine if it will also eliminate low blood sugar. To do so we will give insulin to lower the blood sugar, measure the levels of the hormones that normally raise blood sugar levels (e.g., glucagon and epinephrine) and then stop the insulin and see if blood sugar levels return to normal. Because we anticipate that the transplanted islets will produce insulin, but not glucagon, this study may also tell us if regulated insulin production alone can prevent hypoglycemia in humans.
Trial Health
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
July 18, 2000
CompletedFirst Posted
Study publicly available on registry
July 19, 2000
CompletedJune 24, 2005
November 1, 2001
July 18, 2000
June 23, 2005
Conditions
Interventions
Eligibility Criteria
You may qualify if:
- Clinically stable, insulin dependent islet transplant recipients and matched nondiabetic healthy controls
Contact the study team to confirm eligibility.
Sponsors & Collaborators
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- SINGLE
- Purpose
- TREATMENT
- Sponsor Type
- NIH
Study Record Dates
First Submitted
July 18, 2000
First Posted
July 19, 2000
Last Updated
June 24, 2005
Record last verified: 2001-11