The Effect of Estrogen and Progesterone Levels on Knee and Ankle Joint Laxity

NCT00005923 | Unknown

• 2 other identifiers: NCRR-M01RR00109-0749M01RR000109
• Study Type: observational
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

The proposed research is an observational study designed to compare estrogen and progesterone serum levels with knee and ankle joint laxity, and muscle reaction time as a measure of neuromuscular function. Three groups of women athletes with differing estrogen and progesterone profiles (normal menstrual cycles, amenorrheic, and exogenous estrogen supplementation) and one control group (male collegiate athletes) will be used to compare differences in joint laxity and neuromuscular function. Blood levels of estrogen and progesterone will be measured at four time points across the menstrual cycle. Joint laxity and muscle reaction time will also be measured at each of these points. The investigator hypothesizes that knee and ankle joint laxity and muscle reaction time will significantly increase with increasing estrogen and progesterone levels.

Conditions

Healthy

Keywords

Joint Instability

Eligibility Criteria

• Age: 15 Years - 23 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• pre-collegiate or collegiate athletes

Sponsors & Collaborators

• National Center for Research Resources (NCRR): lead

Study Sites (1)

University of Vermont

Burlington, Vermont, 05405, United States

Location

MeSH Terms

Conditions

Joint Instability

Condition Hierarchy (Ancestors)

Joint Diseases; Musculoskeletal Diseases

Study Design

• Study Type: observational
• Observational Model: NATURAL HISTORY
• Sponsor Type: NIH

Study Record Dates

• First Submitted: June 23, 2000
• First Posted: June 26, 2000
• Last Updated: June 24, 2005

Record last verified: 2001-11

Locations

US (1)