Genetics of Recurrent Early-Onset Depression

NCT00005914 | Completed

• 8 other identifiers: R01MH061686-01R01MH060912R01MH059552R01MH059541R01MH059542R01MH061686R01MH060866DNBBS 7G-GRR
• Study Type: observational
• Target: 2,533
• Locations: 1 country
• Sites: 6

Brief Summary

This nationwide study will create a DNA collection to permit qualified scientists to search for depression-related genes. More than 750 families with at least two siblings who have experienced major depression are needed for the study. Participants will be interviewed about psychiatric and family history, and will be asked to provide a small blood specimen. The identification of predisposing genes can lead to greater understanding of the brain mechanisms involved in severe depression which can in turn lead to the discovery of new treatments. A Certificate of Confidentiality from the federal government ensures that all information will be strictly confidential. Blood specimens are identified only by code number (not by name). Reimbursement is provided.

Conditions

Depression

Keywords

Depression; Depressive Disorder; Family; Genes; Genetic Techniques; Genetics; Linkage (Genetics); Nuclear Family; Recurrence; Severity of Illness Index

Outcome Measures

Primary Outcomes (1)

• Major depressive disorder

  Participants will attend an interview regarding personal and family history of psychiatric disorders, and give a blood specimen. Genotypes from blood samples will be studied for genetic linkage (within families) with the presence of major depressive disorder.

  One patient interview session (typically 2 hours), and blood draw (10-20 minutes)

Study Arms (1)

Probands and family members

Individuals with major depressive disorder who meet study criteria, and members of their families. No intervention. This is a genetic study only.

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Probands will have major depressive disorder meeting the eligibility criteria described below.

You may qualify if:

• Families that have at least TWO ADULT SIBLINGS (brother/brother; sister/sister; brother/sister) who have experienced major depression.
• Depression must be RECURRENT (more than one episode).
• Depression must have started at age 30 or less in one sibling, and at age 40 or less in the other sibling.

You may not qualify if:

• Participants cannot have Bipolar I (manic-depressive) disorder or schizophrenia.

Sponsors & Collaborators

• Stanford University: lead
• National Institute of Mental Health (NIMH): collaborator

Study Sites (6)

Rush Presbyterian - Saint Luke's Med Ctr

Chicago, Illinois, 60612, United States

Location

Univ of Iowa Hosp and Clinic

Iowa City, Iowa, 52242, United States

Location

Johns Hopkins University

Baltimore, Maryland, 21287-7381, United States

Location

New York State Psychiatric Institute / Columbia Univ

New York, New York, 10032, United States

Location

Univ of Pennsylvania

Philadelphia, Pennsylvania, 19104-2648, United States

Location

Univ of Pittsburgh / Western Psychiatric Inst and Clinic

Pittsburgh, Pennsylvania, 15213, United States

Location

Related Links

• Web site for New York Psychiatric Institute
• Web site for University of Iowa

Biospecimen

Retention: SAMPLES WITH DNA

Blood specimens were submitted to the NIMH repository at the Rutgers University Cell and DNA Repository.

MeSH Terms

Conditions

Depression; Depressive Disorder; Recurrence

Condition Hierarchy (Ancestors)

Behavioral Symptoms; Behavior; Mood Disorders; Mental Disorders; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Myrna Weissman

  Columbia University

  PRINCIPAL INVESTIGATOR

• J R DePaulo

  Johns Hopkins University

  PRINCIPAL INVESTIGATOR

• William Scheftner

  Rush University Hospital

  PRINCIPAL INVESTIGATOR

• Raymond Crowe

  University of Iowa

  PRINCIPAL INVESTIGATOR

• Douglas Levinson

  University of Pennsylvania

  PRINCIPAL INVESTIGATOR

• George Zubenko

  University of Pittsburgh

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: FAMILY BASED
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principle Investigator

Study Record Dates

• First Submitted: June 15, 2000
• First Posted: June 16, 2000
• Study Start: October 1, 1999
• Primary Completion: October 1, 2005
• Study Completion: October 1, 2005
• Last Updated: April 19, 2019

Record last verified: 2019-04

Locations

US (6)