NCT00005373

Brief Summary

To study mechanisms of excess coronary ischemia secondary to alterations in autoregulation and arteriolar vasoreactivity in Black Americans with hypertension, varying degree of left ventricular hypertrophy, and angiographically normal or mildly diseased coronary arteries.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Timeline
Completed

Started Sep 1992

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 1992

Completed
5.9 years until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 1998

Completed
1.8 years until next milestone

First Submitted

Initial submission to the registry

May 25, 2000

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 26, 2000

Completed
Last Updated

May 13, 2016

Status Verified

July 1, 2000

First QC Date

May 25, 2000

Last Update Submit

May 12, 2016

Conditions

Cardiovascular DiseasesHeart DiseasesCoronary DiseaseHypertensionMyocardial IschemiaHypertrophy, Left Ventricular

Eligibility Criteria

AgeUp to 100 Years
Sexmale
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Related Publications (5)

  • Houghton JL, Davison CA, Kuhner PA, Torossov MT, Strogatz DS, Carr AA. Heterogeneous vasomotor responses of coronary conduit and resistance vessels in hypertension. J Am Coll Cardiol. 1998 Feb;31(2):374-82. doi: 10.1016/s0735-1097(97)00505-6.

    PMID: 9462582BACKGROUND

  • Houghton JL, Carr AA, Strogatz DS, Michel AI, Phillip JL, Kuhner PA, Smith VE, Breisblatt WM. Coronary vasomotor reactivity among normotensive African and white American subjects with chest pain. Am J Med. 1997 Mar;102(3):245-51. doi: 10.1016/S0002-9343(96)00449-4.

    PMID: 9217592BACKGROUND

  • Houghton JL, Smith VE, Strogatz DS, Henches NL, Breisblatt WM, Carr AA. Effect of African-American race and hypertensive left ventricular hypertrophy on coronary vascular reactivity and endothelial function. Hypertension. 1997 Mar;29(3):706-14. doi: 10.1161/01.hyp.29.3.706.

    PMID: 9052885BACKGROUND

  • Wood WD. Psychological soundness of women on psychiatry clerkship. J Am Med Womens Assoc (1972). 1980 May;35(5):128, 132. No abstract available.

    PMID: 6247382BACKGROUND

  • Houghton JL, Prisant LM, Carr AA, Flowers NC, Frank MJ. Racial differences in myocardial ischemia and coronary flow reserve in hypertension. J Am Coll Cardiol. 1994 Apr;23(5):1123-9. doi: 10.1016/0735-1097(94)90600-9.

    PMID: 8144778BACKGROUND

MeSH Terms

Conditions

Cardiovascular DiseasesHeart DiseasesCoronary DiseaseHypertensionMyocardial IschemiaHypertrophy, Left Ventricular

Condition Hierarchy (Ancestors)

Vascular DiseasesCardiomegalyHypertrophyPathological Conditions, AnatomicalPathological Conditions, Signs and Symptoms

Study Design

Study Type
observational
Sponsor Type
NIH

Study Record Dates

First Submitted

May 25, 2000

First Posted

May 26, 2000

Study Start

September 1, 1992

Study Completion

August 1, 1998

Last Updated

May 13, 2016

Record last verified: 2000-07