Risk Factors For Asthma in Laboratory Animal Allergy

NCT00005283 | Completed

• 2 other identifiers: 2004R01HL030532
• Study Type: observational
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

To identify risk factors which predispose individuals to develop asthma and other manifestations of allergic disease on exposure to laboratory animals in the workplace.

Conditions

Asthma; Lung Diseases

Eligibility Criteria

• Age: Up to 100 Years
• Sex: male
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI): lead

Related Publications (10)

• Corn M, Koegel A, Hall T, Scott A, Newill C, Evans R: Characteristics of Airborne Particles Associated with Animal Allergy in Laboratory Workers. Ann Occup Hyg, 32:435-446 (Suppl 1), 1988

  BACKGROUND

• Evans R III, Summers RJ, Newill CA: Allergic Reactions Caused by Exposure to Animals. In: Lichtenstein LM, Fauci AS (Eds), Current Therapy in Allergy, Immunology and Rheumatology - III. BC Decker Inc, Toronto, Philadelphia, p 5-7, 1988

  BACKGROUND

• Eggleston PA, Newill CA, Ansari AA, Pustelnik A, Lou SR, Evans R 3rd, Marsh DG, Longbottom JL, Corn M. Task-related variation in airborne concentrations of laboratory animal allergens: studies with Rat n I. J Allergy Clin Immunol. 1989 Sep;84(3):347-52. doi: 10.1016/0091-6749(89)90419-3.

  PMID: 2778241 BACKGROUND

• Eggleston PA, Kagey-Sobotka A, Proud D, Adkinson NF Jr, Lichtenstein LM. Disassociation of the release of histamine and arachidonic acid metabolites from osmotically activated basophils and human lung mast cells. Am Rev Respir Dis. 1990 Apr;141(4 Pt 1):960-4. doi: 10.1164/ajrccm/141.4_Pt_1.960.

  PMID: 1691604 BACKGROUND

• Eggleston PA, Ansari AA, Ziemann B, Adkinson NF Jr, Corn M. Occupational challenge studies with laboratory workers allergic to rats. J Allergy Clin Immunol. 1990 Jul;86(1):63-72. doi: 10.1016/s0091-6749(05)80124-1.

  PMID: 2196304 BACKGROUND

• Evans R III, Fortney S, Menkes H, Newill C, Cohens BH: Biological Indicators of Susceptibility. In: Green GM, Baker F (Eds), Work, Health and Productivity. Oxford University Press, 1991.

  BACKGROUND

• Newill CA, Prenger VL, Fish JE, Evans R 3rd, Diamond EL, Wei Q, Eggleston PA. Risk factors for increased airway responsiveness to methacholine challenge among laboratory animal workers. Am Rev Respir Dis. 1992 Dec;146(6):1494-500. doi: 10.1164/ajrccm/146.6.1494.

  PMID: 1456566 BACKGROUND

• Ziemann B, Corn M, Ansari AA, Eggleston P. The effectiveness of the Duo-Flo BioClean unit for controlling airborne antigen levels. Am Ind Hyg Assoc J. 1992 Feb;53(2):138-45. doi: 10.1080/15298669291359401.

  PMID: 1543130 BACKGROUND

• Newill CA, Eggleston PA, Prenger VL, Fish JE, Diamond EL, Wei Q, Evans R 3rd. Prospective study of occupational asthma to laboratory animal allergens: stability of airway responsiveness to methacholine challenge for one year. J Allergy Clin Immunol. 1995 Mar;95(3):707-15. doi: 10.1016/s0091-6749(95)70176-1.

  PMID: 7897154 BACKGROUND

• Eggleston PA, Ansari AA, Adkinson NF Jr, Wood RA. Environmental challenge studies in laboratory animal allergy. Effect of different airborne allergen concentrations. Am J Respir Crit Care Med. 1995 Mar;151(3 Pt 1):640-6. doi: 10.1164/ajrccm.151.3.7881650.

  PMID: 7881650 BACKGROUND

MeSH Terms

Conditions

Asthma; Lung Diseases

Condition Hierarchy (Ancestors)

Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: May 25, 2000
• First Posted: May 26, 2000
• Study Start: July 1, 1983
• Study Completion: June 1, 1990
• Last Updated: February 18, 2016

Record last verified: 2000-05