Prospective Evaluation of Airways Reactivity

NCT00005282 | Completed

• 2 other identifiers: 2003P50HL019170
• Study Type: observational
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

From 1981 to 1991, to characterize the role of allergy and airways responsiveness in modifying growth of lung function in children and young adults in a community-based random population, the Childhood Respiratory Study in East Boston. From 1992 to 1997, to examine the relationship of respiratory symptoms and illnesses, cigarette smoking, airways responsiveness, and markers of inflammation to growth and decline in lung function in two well-characterized and investigated community-based populations of children and adults, the Childhood Respiratory Study in East Boston and the Normative Aging Study.

Conditions

Lung Diseases; Asthma; Lung Diseases, Obstructive; Chronic Obstructive Pulmonary Disease

Eligibility Criteria

• Age: Up to 100 Years
• Sex: male
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI): lead

Related Publications (43)

• Tollerud DJ, Weiss ST, Leung DY. Elevated soluble interleukin-2 receptors in young healthy cigarette smokers: lack of association with atopy or airways hyperresponsiveness. Int Arch Allergy Immunol. 1992;97(1):25-30. doi: 10.1159/000236091.

  PMID: 1582694 BACKGROUND

• Weiss ST. Diet as a risk factor for asthma. Ciba Found Symp. 1997;206:244-57: discussion 253-7.

  PMID: 9257017 BACKGROUND

• Sparrow D, O'Connor GT, Weiss ST, DeMolles D, Ingram RH Jr. Volume history effects and airway responsiveness in middle-aged and older men. The Normative Aging Study. Am J Respir Crit Care Med. 1997 Mar;155(3):888-92. doi: 10.1164/ajrccm.155.3.9117022.

  PMID: 9117022 BACKGROUND

• Shadick NA, Sparrow D, O'Connor GT, DeMolles D, Weiss ST. Relationship of serum IgE concentration to level and rate of decline of pulmonary function: the Normative Aging Study. Thorax. 1996 Aug;51(8):787-92. doi: 10.1136/thx.51.8.787.

  PMID: 8795665 BACKGROUND

• Weiss ST, Segal MR, Sparrow D, Wager C. Relation of FEV1 and peripheral blood leukocyte count to total mortality. The Normative Aging Study. Am J Epidemiol. 1995 Sep 1;142(5):493-8; discussion 499-503. doi: 10.1093/oxfordjournals.aje.a117665.

  PMID: 7677128 BACKGROUND

• Carey VJ, Weiss ST, Tager IB, Leeder SR, Speizer FE. Airways responsiveness, wheeze onset, and recurrent asthma episodes in young adolescents. The East Boston Childhood Respiratory Disease Cohort. Am J Respir Crit Care Med. 1996 Jan;153(1):356-61. doi: 10.1164/ajrccm.153.1.8542143.

  PMID: 8542143 BACKGROUND

• Tager IB, Weiss ST, Rosner B, Speizer FE. Effect of parental cigarette smoking on the pulmonary function of children. Am J Epidemiol. 1979 Jul;110(1):15-26. doi: 10.1093/oxfordjournals.aje.a112783.

  PMID: 463860 BACKGROUND

• Weiss ST, Tager IB, Speizer FE, Rosner B. Persistent wheeze. Its relation to respiratory illness, cigarette smoking, and level of pulmonary function in a population sample of children. Am Rev Respir Dis. 1980 Nov;122(5):697-707. doi: 10.1164/arrd.1980.122.5.697.

  PMID: 7447154 BACKGROUND

• Weinberger SE, Weiss ST, Johnson TS, von Gal E, Balsavich L. Naloxone does not affect bronchoconstriction induced by isocapnic hyperpnea of subfreezing air. Am Rev Respir Dis. 1982 Sep;126(3):468-71. doi: 10.1164/arrd.1982.126.3.468.

  PMID: 7125336 BACKGROUND

• Weiss ST, Tager IB, Schenker M, Speizer FE. The health effects of involuntary smoking. Am Rev Respir Dis. 1983 Nov;128(5):933-42. doi: 10.1164/arrd.1983.128.5.933.

  PMID: 6638684 BACKGROUND

• Weiss ST, Tager IB, Speizer FE. Passive smoking. Its relationship to respiratory symptoms, pulmonary function and nonspecific bronchial responsiveness. Chest. 1983 Dec;84(6):651-2. doi: 10.1378/chest.84.6.651. No abstract available.

  PMID: 6641294 BACKGROUND

• Tager IB, Weiss ST, Munoz A, Rosner B, Speizer FE. Longitudinal study of the effects of maternal smoking on pulmonary function in children. N Engl J Med. 1983 Sep 22;309(12):699-703. doi: 10.1056/NEJM198309223091204.

  PMID: 6888441 BACKGROUND

• Pichurko BM, Weiss ST. The role of infection in asthma: implications for antibiotic therapy. Compr Ther. 1984 Mar;10(3):32-6.

  PMID: 6713812 BACKGROUND

• Weiss ST, Tager IB, Weiss JW, Munoz A, Speizer FE, Ingram RH. Airways responsiveness in a population sample of adults and children. Am Rev Respir Dis. 1984 Jun;129(6):898-902. doi: 10.1164/arrd.1984.129.6.898.

  PMID: 6610372 BACKGROUND

• Weiss ST, Tager IB, Weiss JW, Munoz A, Speizer FE, Ingram RH Jr: The Relationship of Physician-Diagnosed Croup or Bronchiolitis to the Subsequent Development of Increased Levels of Airways Responsiveness. Chest, 85S:9S-10S, 1984

  BACKGROUND

• Welty C, Weiss ST, Tager IB, Munoz A, Becker C, Speizer FE, Ingram RH Jr. The relationship of airways responsiveness to cold air, cigarette smoking, and atopy to respiratory symptoms and pulmonary function in adults. Am Rev Respir Dis. 1984 Aug;130(2):198-203. doi: 10.1164/arrd.1984.130.2.198.

  PMID: 6465674 BACKGROUND

• Weiss ST, Tager IB, Speizer FE: Passive Smoking: The Health Consequences of Smoking: Chronic Obstructive Lung Disease. A Report of the Surgeon General. U.S. Department of Health, Education, and Welfare; 84-50205, pp. 363-410, 1984

  BACKGROUND

• Weiss ST, Speizer FE. Increased levels of airways responsiveness as a risk factor for development of chronic obstructive lung disease. What are the issues? Chest. 1984 Jul;86(1):3-4. doi: 10.1378/chest.86.1.3. No abstract available.

  PMID: 6734287 BACKGROUND

• Weiss ST, Speizer FE: The Epidemiology of Asthma: Risk Factors and Natural History. In: Bronchial Asthma: Mechanisms and Therapeutics, 2nd Edition. Weiss EB, Segal MS, Stein M (Eds). Boston, Little Brown, 1985

  BACKGROUND

• Rosner B, Munoz A, Tager I, Speizer F, Weiss S. The use of an autoregressive model for the analysis of longitudinal data in epidemiologic studies. Stat Med. 1985 Oct-Dec;4(4):457-67. doi: 10.1002/sim.4780040407.

  PMID: 4089350 BACKGROUND

• Tager IB, Munoz A, Rosner B, Weiss ST, Carey V, Speizer FE. Effect of cigarette smoking on the pulmonary function of children and adolescents. Am Rev Respir Dis. 1985 May;131(5):752-9. doi: 10.1164/arrd.1985.131.5.752.

  PMID: 4003920 BACKGROUND

• Weiss ST, Tager IB, Munoz A, Speizer FE. The relationship of respiratory infections in early childhood to the occurrence of increased levels of bronchial responsiveness and atopy. Am Rev Respir Dis. 1985 Apr;131(4):573-8. doi: 10.1164/arrd.1985.131.4.573.

  PMID: 3994151 BACKGROUND

• Tager IB, Weiss ST, Speizer FE. Occurrence of asthma, nonspecific bronchial hyperresponsiveness and atopy. Insights from cross-sectional epidemiologic studies. Chest. 1987 Jun;91(6 Suppl):114S-119S. doi: 10.1378/chest.91.6_supplement.114s.

  PMID: 3556060 BACKGROUND

• Tager IB, Weiss ST, Munoz A, Welty C, Speizer FE. Determinants of response to eucapneic hyperventilation with cold air in a population-based study. Am Rev Respir Dis. 1986 Sep;134(3):502-8. doi: 10.1164/arrd.1986.134.3.502.

  PMID: 3092709 BACKGROUND

• O'Connor GT, Weiss ST, Tager IB, Speizer FE. The effect of passive smoking on pulmonary function and nonspecific bronchial responsiveness in a population-based sample of children and young adults. Am Rev Respir Dis. 1987 Apr;135(4):800-4. doi: 10.1164/arrd.1987.135.4.800. No abstract available.

  PMID: 3565928 BACKGROUND

• Munoz A, Weiss ST, Tager IB, Rosner B, Speizer FE. Statistical methods for the analysis of the association between bronchial responsiveness and pulmonary function changes. Bull Eur Physiopathol Respir. 1987 Jul-Aug;23(4):377-81.

  PMID: 3690024 BACKGROUND

• Tager IB, Segal MR, Munoz A, Weiss ST, Speizer FE. The effect of maternal cigarette smoking on the pulmonary function of children and adolescents. Analyses of data from two populations. Am Rev Respir Dis. 1987 Dec;136(6):1366-70. doi: 10.1164/ajrccm/136.6.1366.

  PMID: 3688640 BACKGROUND

• Redline S, Tager IB, Castile RG, Weiss ST, Barr M, Speizer FE. Assessment of the usefulness of helium-oxygen maximal expiratory flow curves in epidemiologic studies of lung disease in children. Am Rev Respir Dis. 1987 Oct;136(4):834-40. doi: 10.1164/ajrccm/136.4.834.

  PMID: 3662236 BACKGROUND

• Rosner B, Munoz A. Autoregressive modelling for the analysis of longitudinal data with unequally spaced examinations. Stat Med. 1988 Jan-Feb;7(1-2):59-71. doi: 10.1002/sim.4780070110.

  PMID: 3353613 BACKGROUND

• Tager IB, Segal MR, Speizer FE, Weiss ST. The natural history of forced expiratory volumes. Effect of cigarette smoking and respiratory symptoms. Am Rev Respir Dis. 1988 Oct;138(4):837-49. doi: 10.1164/ajrccm/138.4.837.

  PMID: 3202458 BACKGROUND

• Segal MR, Weiss ST, Speizer FE, Tager IB. Smoothing methods for epidemiologic analysis. Stat Med. 1988 May;7(5):601-11. doi: 10.1002/sim.4780070507.

  PMID: 3387719 BACKGROUND

• Gold DR, Weiss ST, Tager IB, Segal MR, Speizer FE. Comparison of questionnaire and diary methods in acute childhood respiratory illness surveillance. Am Rev Respir Dis. 1989 Mar;139(3):847-9. doi: 10.1164/ajrccm/139.3.847.

  PMID: 2923381 BACKGROUND

• Redline S, Tager IB, Segal MR, Gold D, Speizer FE, Weiss ST. The relationship between longitudinal change in pulmonary function and nonspecific airway responsiveness in children and young adults. Am Rev Respir Dis. 1989 Jul;140(1):179-84. doi: 10.1164/ajrccm/140.1.179.

  PMID: 2751164 BACKGROUND

• Redline S, Tager IB, Speizer FE, Rosner B, Weiss ST. Longitudinal variability in airway responsiveness in a population-based sample of children and young adults. Intrinsic and extrinsic contributing factors. Am Rev Respir Dis. 1989 Jul;140(1):172-8. doi: 10.1164/ajrccm/140.1.172.

  PMID: 2751163 BACKGROUND

• Sherman CB, Tosteson TD, Tager IB, Speizer FE, Weiss ST. Early childhood predictors of asthma. Am J Epidemiol. 1990 Jul;132(1):83-95. doi: 10.1093/oxfordjournals.aje.a115646.

  PMID: 2356817 BACKGROUND

• Weiss ST, Tosteson TD, Segal MR, Tager IB, Redline S, Speizer FE. Effects of asthma on pulmonary function in children. A longitudinal population-based study. Am Rev Respir Dis. 1992 Jan;145(1):58-64. doi: 10.1164/ajrccm/145.1.58.

  PMID: 1731600 BACKGROUND

• Schwartz J, Weiss ST. Relationship of skin test reactivity to decrements in pulmonary function in children with asthma or frequent wheezing. Am J Respir Crit Care Med. 1995 Dec;152(6 Pt 1):2176-80. doi: 10.1164/ajrccm.152.6.8520794.

  PMID: 8520794 BACKGROUND

• Weiss ST. The origins of childhood asthma. Monaldi Arch Chest Dis. 1994 Apr;49(2):154-8.

  PMID: 8049701 BACKGROUND

• Lee J, Sparrow D, Vokonas PS, Landsberg L, Weiss ST. Uric acid and coronary heart disease risk: evidence for a role of uric acid in the obesity-insulin resistance syndrome. The Normative Aging Study. Am J Epidemiol. 1995 Aug 1;142(3):288-94. doi: 10.1093/oxfordjournals.aje.a117634.

  PMID: 7631632 BACKGROUND

• Annema JT, Sparrow D, O'Connor GT, Rijcken B, Koeter GH, Postma DS, Weiss ST. Chronic respiratory symptoms and airway responsiveness to methacholine are associated with eosinophilia in older men: the Normative Aging Study. Eur Respir J. 1995 Jan;8(1):62-9. doi: 10.1183/09031936.95.08010062.

  PMID: 7744195 BACKGROUND

• Weiss ST, Sparrow D, O'Connor GT. The interrelationship among allergy, airways responsiveness, and asthma. J Asthma. 1993;30(5):329-49. doi: 10.3109/02770909309056738. No abstract available.

  PMID: 8407734 BACKGROUND

• Sparrow D, O'Connor GT, Basner RC, Rosner B, Weiss ST. Predictors of the new onset of wheezing among middle-aged and older men. The Normative Aging Study. Am Rev Respir Dis. 1993 Feb;147(2):367-71. doi: 10.1164/ajrccm/147.2.367.

  PMID: 8430960 BACKGROUND

• Sparrow D, O'Connor GT, Rosner B, Weiss ST. Predictors of longitudinal change in methacholine airway responsiveness among middle-aged and older men: the Normative Aging Study. Am J Respir Crit Care Med. 1994 Feb;149(2 Pt 1):376-81. doi: 10.1164/ajrccm.149.2.8306033.

  PMID: 8306033 BACKGROUND

MeSH Terms

Conditions

Lung Diseases; Asthma; Lung Diseases, Obstructive; Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Respiratory Tract Diseases; Bronchial Diseases; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: May 25, 2000
• First Posted: May 26, 2000
• Study Start: December 1, 1981
• Study Completion: November 1, 1997
• Last Updated: February 18, 2016

Record last verified: 2001-04