Multicenter Study of Silent Myocardial Ischemia (MSSMI)

NCT00005216 | Completed

• 2 other identifiers: 1095R01HL038702
• Study Type: observational
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

To determine if silent myocardial ischemia was associated with an increased risk of cardiac mortality and morbidity during a one to three year follow-up in patients with coronary heart disease.

Conditions

Cardiovascular Diseases; Coronary Disease; Myocardial Ischemia; Heart Diseases; Myocardial Infarction; Angina, Unstable; Arrhythmia

Eligibility Criteria

• Age: 0 Years - 100 Years
• Sex: male
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• University of Rochester: lead
• National Heart, Lung, and Blood Institute (NHLBI): collaborator

Related Publications (14)

• Moss AJ, Benhorin J. Prognosis and management after a first myocardial infarction. N Engl J Med. 1990 Mar 15;322(11):743-53. doi: 10.1056/NEJM199003153221107. No abstract available.

  PMID: 2407955 BACKGROUND

• Bigger JT Jr, Hoover CA, Steinman RC, Rolnitzky LM, Fleiss JL. Autonomic nervous system activity during myocardial ischemia in man estimated by power spectral analysis of heart period variability. The Multicenter Study of Silent Myocardial Ischemia Investigators. Am J Cardiol. 1990 Aug 15;66(4):497-8. doi: 10.1016/0002-9149(90)90712-a. No abstract available.

  PMID: 2201185 BACKGROUND

• Freedland KE, Carney RM, Krone RJ, Case NB, Case RB. Psychological determinants of anginal pain perception during exercise testing of stable patients after recovery from acute myocardial infarction or unstable angina pectoris. Am J Cardiol. 1996 Jan 1;77(1):1-4. doi: 10.1016/s0002-9149(97)89124-2.

  PMID: 8540443 BACKGROUND

• Bodenheimer MM, Wackers FJ, Schwartz RG, Brown M. Prognostic significance of a fixed thallium defect one to six months after onset of acute myocardial infarction or unstable angina. Multicenter Myocardial Ischemia Research Group. Am J Cardiol. 1994 Dec 15;74(12):1196-200. doi: 10.1016/0002-9149(94)90547-9.

  PMID: 7977089 BACKGROUND

• Krone RJ, Gregory JJ, Freedland KE, Kleiger RE, Wackers FJ, Bodenheimer MM, Benhorin J, Schwartz RG, Parker JO, Van Voorhees L, et al. Limited usefulness of exercise testing and thallium scintigraphy in evaluation of ambulatory patients several months after recovery from an acute coronary event: implications for management of stable coronary heart disease. Multicenter Myocardial Ischemia Research Group. J Am Coll Cardiol. 1994 Nov 1;24(5):1274-81. doi: 10.1016/0735-1097(94)90109-0.

  PMID: 7930250 BACKGROUND

• Moss AJ, Goldstein RE, Hall WJ, Bigger JT Jr, Fleiss JL, Greenberg H, Bodenheimer M, Krone RJ, Marcus FI, Wackers FJ, et al. Detection and significance of myocardial ischemia in stable patients after recovery from an acute coronary event. Multicenter Myocardial Ischemia Research Group. JAMA. 1993 May 12;269(18):2379-85.

  PMID: 8479063 BACKGROUND

• Zareba W, Moss AJ, Raubertas RF. Risk of subsequent cardiac events in stable convalescing patients after first non-Q-wave and Q-wave myocardial infarction: the limited role of non-invasive testing. The Multicenter Myocardial Ischemia Research Group. Coron Artery Dis. 1994 Dec;5(12):1009-18. doi: 10.1097/00019501-199412000-00008.

  PMID: 7728293 BACKGROUND

• Wackers FJ, Bodenheimer M, Fleiss JL, Brown M. Factors affecting uniformity in interpretation of planar thallium-201 imaging in a multicenter trial. The Multicenter Study on Silent Myocardial Ischemia (MSSMI) Thallium-201 Investigators. J Am Coll Cardiol. 1993 Apr;21(5):1064-74. doi: 10.1016/0735-1097(93)90226-q.

  PMID: 8459059 BACKGROUND

• Moriel M, Benhorin J, Brown MW, Raubertas RF, Severski PK, Van Voohees L, Bodenheimer MM, Tzivoni D, Wackers FJ, Mass AJ. Detection and significance of myocardial ischemia in women versus men within six months of acute myocardial infarction or unstable angina. The Multicenter Myocardial Ischemia Research Group. Am J Cardiol. 1996 Apr 15;77(10):798-804. doi: 10.1016/s0002-9149(97)89172-2.

  PMID: 8623730 BACKGROUND

• Goldstein RE, Andrews M, Hall WJ, Moss AJ. Marked reduction in long-term cardiac deaths with aspirin after a coronary event. Multicenter Myocardial Ischemia Research Group. J Am Coll Cardiol. 1996 Aug;28(2):326-30. doi: 10.1016/0735-1097(96)00150-7.

  PMID: 8800105 BACKGROUND

• Narins CR, Zareba W, Moss AJ, Goldstein RE, Hall WJ. Clinical implications of silent versus symptomatic exercise-induced myocardial ischemia in patients with stable coronary disease. J Am Coll Cardiol. 1997 Mar 15;29(4):756-63. doi: 10.1016/s0735-1097(96)00585-2.

  PMID: 9091521 BACKGROUND

• Nakamura Y, Moss AJ, Brown MW, Kinoshita M, Kawai C. Differential effects of beta-blockers in patients after recovery from myocardial infarction and after recovery from unstable angina. Multicenter Myocardial Ischemia Research Group. Heart Vessels. 1997;Suppl 12:160-1.

  PMID: 9476569 BACKGROUND

• Freedland KE, Nakamura Y, Carney RM, Case RB, Case NB, Kawai C, Krone RJ, Kato N, Kinoshita M. Angina pectoris after recovery from an acute coronary event--the role of psychological factors in Japanese vs North American patients. Jpn Circ J. 1997 Apr;61(4):299-307. doi: 10.1253/jcj.61.299.

  PMID: 9152781 BACKGROUND

• Nakamura Y, Kawai C, Moss AJ, Raubertas RF, Brown MW, Kinoshita M, Sasayama S, Nonogi H, Omae T, Tamaki S, Fujita M, Tanaka N, Hosoda S, Inoue H, Sugimoto T, Iinuma H, Kato K, Tamaki N, Sugiura N. Comparison between Japan and North America in the post-hospital course after recovery from an acute coronary event. Int J Cardiol. 1996 Aug;55(3):245-54. doi: 10.1016/0167-5273(96)02701-5.

  PMID: 8877424 BACKGROUND

MeSH Terms

Conditions

Cardiovascular Diseases; Coronary Disease; Myocardial Ischemia; Heart Diseases; Myocardial Infarction; Angina, Unstable; Arrhythmias, Cardiac

Condition Hierarchy (Ancestors)

Vascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis; Angina Pectoris; Chest Pain; Pain; Neurologic Manifestations; Signs and Symptoms

Study Design

• Study Type: observational
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 25, 2000
• First Posted: May 26, 2000
• Study Start: April 1, 1988
• Study Completion: December 1, 1994
• Last Updated: November 10, 2025

Record last verified: 2025-11