NCT00005153

Brief Summary

To identify genetic and environmental risk factors for congenital cardiac disease.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Timeline
Completed

Started Dec 1980

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 1, 1980

Completed
17.9 years until next milestone

Study Completion

Last participant's last visit for all outcomes

November 1, 1998

Completed
1.6 years until next milestone

First Submitted

Initial submission to the registry

May 25, 2000

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 26, 2000

Completed
Last Updated

February 29, 2016

Status Verified

October 1, 2001

First QC Date

May 25, 2000

Last Update Submit

February 26, 2016

Conditions

Cardiovascular DiseasesHeart DiseasesDefect, Congenital Heart

Eligibility Criteria

AgeUp to 100 Years
Sexmale
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Related Publications (42)

  • Scanlon KS, Ferencz C, Loffredo CA, Wilson PD, Correa-Villasenor A, Khoury MJ, Willett WC. Preconceptional folate intake and malformations of the cardiac outflow tract. Baltimore-Washington Infant Study Group. Epidemiology. 1998 Jan;9(1):95-8.

    PMID: 9430276BACKGROUND

  • Lurie IW, Ferencz C. VACTERL-hydrocephaly, DK-phocomelia, and cerebro-cardio-radio-reno-rectal community. Am J Med Genet. 1997 May 16;70(2):144-9. doi: 10.1002/(sici)1096-8628(19970516)70:23.0.co;2-y.

    PMID: 9128933BACKGROUND

  • Lurie IW, Kappetein AP, Loffredo CA, Ferencz C. Non-cardiac malformations in individuals with outflow tract defects of the heart: the Baltimore-Washington Infant Study (1981-1989). Am J Med Genet. 1995 Oct 23;59(1):76-84. doi: 10.1002/ajmg.1320590116.

    PMID: 8849016BACKGROUND

  • Teratogenicity of progestational agents. Teratology. 1984 Feb;29(1):131-46. doi: 10.1002/tera.1420290115. No abstract available.

    PMID: 6701803BACKGROUND

  • Ferencz C, Rubin JD, McCarter RJ, Wilson PD, Brenner JI, Neill CA, Perry LW, Hepner SI, Downing JW: Association of Blood Disorders and Congenital Heart Disease (Letter). Teratology, 29(2):313, 1984

    BACKGROUND

  • Ferencz C, Rubin JD, McCarter RJ, Wilson PD, Boughman JA, Brenner JI, Neill CA, Perry LW, Hepner SI, Downing JW. Hematologic disorders and congenital cardiovascular malformations: converging lines of research. J Med. 1984;15(5-6):337-54.

    PMID: 6399520BACKGROUND

  • Ferencz C, Rubin JD, McCarter RJ, Brenner JI, Neill CA, Perry LW, Hepner SI, Downing JW. Congenital heart disease: prevalence at livebirth. The Baltimore-Washington Infant Study. Am J Epidemiol. 1985 Jan;121(1):31-6. doi: 10.1093/oxfordjournals.aje.a113979.

    PMID: 3964990BACKGROUND

  • Ferencz C, Rubin JD, McCarter RJ, Brenner JI, Neill CA, Perry LW, Hepner SI, Downing JW. Maternal mitral valve prolapse and congenital heart disease in the offspring. Am Heart J. 1985 Oct;110(4):899-900. doi: 10.1016/0002-8703(85)90483-1. No abstract available.

    PMID: 4050668BACKGROUND

  • Kaden GG, McCarter RJ, Johnson SF, Ferencz C. Physician-patient communication. Understanding congenital heart disease. Am J Dis Child. 1985 Oct;139(10):995-9. doi: 10.1001/archpedi.1985.02140120041025.

    PMID: 4036904BACKGROUND

  • Rubin JD, Ferencz C, McCarter RJ, Wilson PD, Boughman JA, Brenner JI, Neill CA, Perry LW, Hepner SI, Downing JW. Congenital cardiovascular malformations in the Baltimore-Washington area. Md Med J. 1985 Nov;34(11):1079-83. No abstract available.

    PMID: 3853721BACKGROUND

  • Rubin JD, Ferencz C. Subsequent pregnancy in mothers of infants with congenital heart disease. Pediatrics. 1985 Sep;76(3):371-4.

    PMID: 4034297BACKGROUND

  • Ferencz C. The etiology of congenital cardiovascular malformations: observations on genetic risks with implications for further birth defects research. J Med. 1985;16(5-6):497-508.

    PMID: 2937867BACKGROUND

  • Ferencz C. Offspring of fathers with cardiovascular malformations. Am Heart J. 1986 Jun;111(6):1212-3. doi: 10.1016/0002-8703(86)90034-7. No abstract available.

    PMID: 3716999BACKGROUND

  • Boughman JA, Berg KA, Astemborski JA, Clark EB, McCarter RJ, Rubin JD, Ferencz C. Familial risks of congenital heart defect assessed in a population-based epidemiologic study. Am J Med Genet. 1987 Apr;26(4):839-49. doi: 10.1002/ajmg.1320260411.

    PMID: 3591826BACKGROUND

  • Johnson SF, McCarter RJ, Ferencz C. Changes in alcohol, cigarette, and recreational drug use during pregnancy: implications for intervention. Am J Epidemiol. 1987 Oct;126(4):695-702. doi: 10.1093/oxfordjournals.aje.a114709.

    PMID: 3498364BACKGROUND

  • Ferencz C, Rubin JD, McCarter RJ, Boughman JA, Wilson PD, Brenner JI, Neill CA, Perry LW, Hepner SI, Downing JW. Cardiac and noncardiac malformations: observations in a population-based study. Teratology. 1987 Jun;35(3):367-78. doi: 10.1002/tera.1420350311.

    PMID: 3629517BACKGROUND

  • Boughman JA, Astemborski JA, Berg KA, Clark EB, Ferencz C. Variation in expression of congenital cardiovascular malformations within and among families. Basic Life Sci. 1988;43:93-103. doi: 10.1007/978-1-4684-5460-4_10. No abstract available.

    PMID: 3365227BACKGROUND

  • Wilson PD, Ferencz C, Dischinger PC, Brenner JI, Zeger SL. Twenty-four-hour ambulatory blood pressure in normotensive adolescent children of hypertensive and normotensive parents. Am J Epidemiol. 1988 May;127(5):946-54. doi: 10.1093/oxfordjournals.aje.a114898.

    PMID: 3358415BACKGROUND

  • Maestri NE, Beaty TH, Liang KY, Boughman JA, Ferencz C. Assessing familial aggregation of congenital cardiovascular malformations in case-control studies. Genet Epidemiol. 1988;5(5):343-54. doi: 10.1002/gepi.1370050505.

    PMID: 3215508BACKGROUND

  • Ferencz C, Neill CA, Boughman JA, Rubin JD, Brenner JI, Perry LW. Congenital cardiovascular malformations associated with chromosome abnormalities: an epidemiologic study. J Pediatr. 1989 Jan;114(1):79-86. doi: 10.1016/s0022-3476(89)80605-5.

    PMID: 2521249BACKGROUND

  • Ferencz C. Origin of congenital heart disease: reflections on Maude Abbott's work. Can J Cardiol. 1989 Jan-Feb;5(1):4-9.

    PMID: 2645982BACKGROUND

  • Ferencz C, Boughman JA, Neill CA, Brenner JI, Perry LW. Congenital cardiovascular malformations: questions on inheritance. Baltimore-Washington Infant Study Group. J Am Coll Cardiol. 1989 Sep;14(3):756-63. doi: 10.1016/0735-1097(89)90122-8.

    PMID: 2768723BACKGROUND

  • Martin GR, Perry LW, Ferencz C. Increased prevalence of ventricular septal defect: epidemic or improved diagnosis. Pediatrics. 1989 Feb;83(2):200-3.

    PMID: 2783625BACKGROUND

  • Berg KA, Astemborski JA, Boughman JA, Ferencz C. Congenital cardiovascular malformations in twins and triplets from a population-based study. Am J Dis Child. 1989 Dec;143(12):1461-3. doi: 10.1001/archpedi.1989.02150240083023.

    PMID: 2589279BACKGROUND

  • Ferencz C, Rubin JD, McCarter RJ, Clark EB. Maternal diabetes and cardiovascular malformations: predominance of double outlet right ventricle and truncus arteriosus. Teratology. 1990 Mar;41(3):319-26. doi: 10.1002/tera.1420410309.

    PMID: 2326756BACKGROUND

  • Ferencz C. On the birth prevalence of congenital heart disease. J Am Coll Cardiol. 1990 Dec;16(7):1701-2. doi: 10.1016/0735-1097(90)90322-g. No abstract available.

    PMID: 2254556BACKGROUND

  • Carmi R, Boughman JA. Pentalogy of Cantrell and associated midline anomalies: a possible ventral midline developmental field. Am J Med Genet. 1992 Jan 1;42(1):90-5. doi: 10.1002/ajmg.1320420118.

    PMID: 1308371BACKGROUND

  • Carmi R, Boughman JA, Ferencz C. Endocardial cushion defect: further studies of "isolated" versus "syndromic" occurrence. Am J Med Genet. 1992 Jun 1;43(3):569-75. doi: 10.1002/ajmg.1320430313.

    PMID: 1534968BACKGROUND

  • Ferencz C, Neill CA. Cardiomyopathy in infancy: observations in an epidemiologic study. Pediatr Cardiol. 1992 Apr;13(2):65-71. doi: 10.1007/BF00798206.

    PMID: 1614921BACKGROUND

  • Correa-Villasenor A, Ferencz C, Boughman JA, Neill CA. Total anomalous pulmonary venous return: familial and environmental factors. The Baltimore-Washington Infant Study Group. Teratology. 1991 Oct;44(4):415-28. doi: 10.1002/tera.1420440408.

    PMID: 1962287BACKGROUND

  • Correa-Villasenor A, McCarter R, Downing J, Ferencz C. White-black differences in cardiovascular malformations in infancy and socioeconomic factors. The Baltimore-Washington Infant Study Group. Am J Epidemiol. 1991 Aug 15;134(4):393-402. doi: 10.1093/oxfordjournals.aje.a116101.

    PMID: 1877600BACKGROUND

  • Rosenthal GL, Wilson PD, Permutt T, Boughman JA, Ferencz C. Birth weight and cardiovascular malformations: a population-based study. The Baltimore-Washington Infant Study. Am J Epidemiol. 1991 Jun 15;133(12):1273-81. doi: 10.1093/oxfordjournals.aje.a115839.

    PMID: 2063835BACKGROUND

  • Lurie IW, Magee CA, Sun CC, Ferencz C. 'Microgastria--limb reduction' complex with congenital heart disease and twinning. Clin Dysmorphol. 1995 Apr;4(2):150-5.

    PMID: 7606322BACKGROUND

  • Correa-Villasenor A, Ferencz C, Neill CA, Wilson PD, Boughman JA. Ebstein's malformation of the tricuspid valve: genetic and environmental factors. The Baltimore-Washington Infant Study Group. Teratology. 1994 Aug;50(2):137-47. doi: 10.1002/tera.1420500208.

    PMID: 7801301BACKGROUND

  • Ferencz C, Boughman JA. Congenital heart disease in adolescents and adults. Teratology, genetics, and recurrence risks. Cardiol Clin. 1993 Nov;11(4):557-67.

    PMID: 8252559BACKGROUND

  • Wilson PD, Correa-Villasenor A, Loffredo CA, Ferencz C. Temporal trends in prevalence of cardiovascular malformations in Maryland and the District of Columbia, 1981-1988. The Baltimore-Washington Infant Study Group. Epidemiology. 1993 May;4(3):259-65.

    PMID: 8512990BACKGROUND

  • Rubin JD, Ferencz C, Loffredo C. Use of prescription and non-prescription drugs in pregnancy. The Baltimore-Washington Infant Study Group. J Clin Epidemiol. 1993 Jun;46(6):581-9. doi: 10.1016/0895-4356(93)90132-k.

    PMID: 8501486BACKGROUND

  • Kuehl KS, Loffredo CA, Ferencz C. Failure to diagnose congenital heart disease in infancy. Pediatrics. 1999 Apr;103(4 Pt 1):743-7. doi: 10.1542/peds.103.4.743.

    PMID: 10103296BACKGROUND

  • Correa-Villasenor A, Ferencz C, Loffredo C, Magee C. Paternal exposures and cardiovascular malformations. The Baltimore-Washington Infant Study Group. J Expo Anal Environ Epidemiol. 1993;3 Suppl 1:173-85.

    PMID: 9857303BACKGROUND

  • Wilson PD, Loffredo CA, Correa-Villasenor A, Ferencz C. Attributable fraction for cardiac malformations. Am J Epidemiol. 1998 Sep 1;148(5):414-23. doi: 10.1093/oxfordjournals.aje.a009666.

    PMID: 9737553BACKGROUND

  • Rosenthal GL. Patterns of prenatal growth among infants with cardiovascular malformations: possible fetal hemodynamic effects. Am J Epidemiol. 1996 Mar 1;143(5):505-13. doi: 10.1093/oxfordjournals.aje.a008771.

    PMID: 8610666BACKGROUND

  • Loffredo CA, Silbergeld EK, Ferencz C, Zhang J. Association of transposition of the great arteries in infants with maternal exposures to herbicides and rodenticides. Am J Epidemiol. 2001 Mar 15;153(6):529-36. doi: 10.1093/aje/153.6.529.

    PMID: 11257060BACKGROUND

MeSH Terms

Conditions

Cardiovascular DiseasesHeart DiseasesHeart Defects, Congenital

Condition Hierarchy (Ancestors)

Cardiovascular AbnormalitiesCongenital AbnormalitiesCongenital, Hereditary, and Neonatal Diseases and Abnormalities

Study Design

Study Type
observational
Sponsor Type
NIH

Study Record Dates

First Submitted

May 25, 2000

First Posted

May 26, 2000

Study Start

December 1, 1980

Study Completion

November 1, 1998

Last Updated

February 29, 2016

Record last verified: 2001-10