NCT00004274

Brief Summary

RATIONALE: Turner's syndrome is a disease in which females are missing all or part of one X chromosome and do not produce estrogen. Giving estrogen is standard treatment for girls who have Turner's syndrome. Estrogen may be effective treatment for mental and social functioning problems experienced by girls with Turner's syndrome. PURPOSE: Clinical trial to study the effectiveness of long term estrogen therapy on mental and social functioning in girls who have Turner's syndrome.

Trial Health

80
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
260

participants targeted

Target at P75+ for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 1, 1990

Completed
9.7 years until next milestone

First Submitted

Initial submission to the registry

October 18, 1999

Completed
1 day until next milestone

First Posted

Study publicly available on registry

October 19, 1999

Completed
Last Updated

June 24, 2005

Status Verified

October 1, 2003

First QC Date

October 18, 1999

Last Update Submit

June 23, 2005

Conditions

Turner's Syndrome

Keywords

Turner's syndromegenetic diseases and dysmorphic syndromesrare disease

Interventions

EstrogenDRUG

Eligibility Criteria

Age8 Years - 12 Years
Sexfemale
Healthy VolunteersYes
Age GroupsChild (0-17)
PROTOCOL ENTRY CRITERIA: * Girls aged 8 and 12 years with Turner's syndrome-compatible karyotype * Age-matched girls without Turner's syndrome entered as controls * Concurrent registration on Thomas Jefferson University growth study required of subjects with Turner's syndrome

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Study Sites (1)

Jefferson Medical College of Thomas Jefferson University

Philadelphia, Pennsylvania, 19107-5083, United States

Location

MeSH Terms

Conditions

Turner SyndromeGenetic Diseases, InbornRare Diseases

Interventions

Estrogens

Condition Hierarchy (Ancestors)

Gonadal DysgenesisDisorders of Sex DevelopmentUrogenital AbnormalitiesFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesSex Chromosome Disorders of Sex DevelopmentMale Urogenital DiseasesHeart Defects, CongenitalCardiovascular AbnormalitiesCardiovascular DiseasesHeart DiseasesCongenital AbnormalitiesCongenital, Hereditary, and Neonatal Diseases and AbnormalitiesSex Chromosome DisordersChromosome DisordersGonadal DisordersEndocrine System DiseasesDisease AttributesPathologic ProcessesPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

HormonesHormones, Hormone Substitutes, and Hormone AntagonistsPhysiological Effects of DrugsPharmacologic ActionsChemical Actions and Uses

Study Officials

  • Judith Levine Ross

    Jefferson Medical College of Thomas Jefferson University

    STUDY CHAIR

Study Design

Study Type
interventional
Phase
not applicable
Purpose
TREATMENT
Sponsor Type
NIH

Study Record Dates

First Submitted

October 18, 1999

First Posted

October 19, 1999

Study Start

February 1, 1990

Last Updated

June 24, 2005

Record last verified: 2003-10

Locations

US(1)