NCT00001981

Brief Summary

The purpose of this study is to investigate the treatment and natural history of acromegaly. We have a longstanding interest in acromegaly treatment, and a cohort that has been followed for 30 years, or more in some cases. We will continue to follow patients and recruit new patients for treatment and follow-up. Blood and pituitary tumor tissue (when available through clinical care) will be saved for future analyses related to acromegaly.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
117

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Oct 1991

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 2, 1991

Completed
8.3 years until next milestone

First Submitted

Initial submission to the registry

January 21, 2000

Completed
3 days until next milestone

First Posted

Study publicly available on registry

January 24, 2000

Completed
20.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 20, 2020

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

November 20, 2020

Completed
Last Updated

November 27, 2020

Status Verified

November 1, 2020

Enrollment Period

29.2 years

First QC Date

January 21, 2000

Last Update Submit

November 24, 2020

Conditions

AcromegalyPituitary Neoplasm

Keywords

Acromegaly

Outcome Measures

Primary Outcomes (1)

  • resolution of IGF-1 Growth Hormone abnormality

    resolution of IGF-1 abnormality

    every 6 months & at end of study

Study Arms (1)

Patients with acromegaly

Patients with acromegaly

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

The study involved patients who were referred to us and had acromegaly.@@@@@@

You may qualify if:

  • Patients will be enrolled who are 18 years of age or over who are referred for care.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Location

Related Links

MeSH Terms

Conditions

AcromegalyPituitary Neoplasms

Condition Hierarchy (Ancestors)

Bone Diseases, EndocrineBone DiseasesMusculoskeletal DiseasesHyperpituitarismPituitary DiseasesHypothalamic DiseasesBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesEndocrine System DiseasesEndocrine Gland NeoplasmsNeoplasms by SiteNeoplasmsHypothalamic NeoplasmsSupratentorial NeoplasmsBrain NeoplasmsCentral Nervous System NeoplasmsNervous System Neoplasms

Study Officials

  • Phillip Gorden, M.D.

    National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
NIH
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 21, 2000

First Posted

January 24, 2000

Study Start

October 2, 1991

Primary Completion

November 20, 2020

Study Completion

November 20, 2020

Last Updated

November 27, 2020

Record last verified: 2020-11

Locations

US(1)