NCT00001926

Brief Summary

The purpose of this study is to test the belief that specific areas of the brain are connected differently in blind patients than patients with sight. In addition, the study will examine the different anatomical connections between brain areas of patients who became blind early in life versus patients who became blind later.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
45

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Apr 1999

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 1999

Completed
7 months until next milestone

First Submitted

Initial submission to the registry

November 3, 1999

Completed
1 day until next milestone

First Posted

Study publicly available on registry

November 4, 1999

Completed
4 years until next milestone

Study Completion

Last participant's last visit for all outcomes

November 1, 2003

Completed
Last Updated

March 4, 2008

Status Verified

November 1, 2003

First QC Date

November 3, 1999

Last Update Submit

March 3, 2008

Conditions

BlindnessBrain MappingHealthy

Keywords

PlasticityMagnetic StimulationPETBlindBrailleTranscranial Magnetic Stimulation

Interventions

O15DRUG
Cadwell rTMSDEVICE

Eligibility Criteria

Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • Subjects with late blindness.
  • Subjects with early blindness.
  • Sighted volunteers.
  • Age between 18 and 65 years.

You may not qualify if:

  • Subjects with personal or family history of seizures or other neurological or demyelinating disorders.
  • Pregnant women tested after urine pregnancy test.
  • Subjects with metal in the cranium except mouth.
  • Subjects with intracardiac lines and implanted medication pumps.
  • Subjects with increased intracranial pressure as evaluated by clinical means.
  • Subjects with cardiac pacemakers.
  • Intake or neuroleptics.
  • Subjects with blindness secondary to degenerative CNS diseases.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

National Institute of Neurological Disorders and Stroke (NINDS)

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

  • Cohen LG, Bandinelli S, Findley TW, Hallett M. Motor reorganization after upper limb amputation in man. A study with focal magnetic stimulation. Brain. 1991 Feb;114 ( Pt 1B):615-27. doi: 10.1093/brain/114.1.615.

    PMID: 2004259BACKGROUND

  • Fuhr P, Cohen LG, Dang N, Findley TW, Haghighi S, Oro J, Hallett M. Physiological analysis of motor reorganization following lower limb amputation. Electroencephalogr Clin Neurophysiol. 1992 Feb;85(1):53-60. doi: 10.1016/0168-5597(92)90102-h.

    PMID: 1371745BACKGROUND

  • Kew JJ, Ridding MC, Rothwell JC, Passingham RE, Leigh PN, Sooriakumaran S, Frackowiak RS, Brooks DJ. Reorganization of cortical blood flow and transcranial magnetic stimulation maps in human subjects after upper limb amputation. J Neurophysiol. 1994 Nov;72(5):2517-24. doi: 10.1152/jn.1994.72.5.2517.

    PMID: 7884476BACKGROUND

MeSH Terms

Conditions

Blindness

Condition Hierarchy (Ancestors)

Vision DisordersSensation DisordersNeurologic ManifestationsNervous System DiseasesEye DiseasesSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Design

Study Type
observational
Sponsor Type
NIH

Study Record Dates

First Submitted

November 3, 1999

First Posted

November 4, 1999

Study Start

April 1, 1999

Study Completion

November 1, 2003

Last Updated

March 4, 2008

Record last verified: 2003-11

Locations

US(1)