Collection of Blood and Bone Marrow From Healthy Volunteers and Patients for Research Purposes

NCT00001627 | Completed

• 2 other identifiers: 97013097-H-0130
• Study Type: observational
• Target: 154
• Locations: 1 country
• Sites: 1

Brief Summary

This study is designed to provide bone marrow and/or blood cells for other research studies. Patients participating in this study will be asked to provide small amounts of medical information and undergo a limited physical examination designed to detect the presence of any obvious blood disease. A blood and bone marrow sample will be obtained to verify that the patient has normal blood cell production. Researchers plan to obtain bone marrow samples to be used in laboratory studies directed toward understanding the formation of blood cells. Bone marrow samples will be taken from the hip bone of patients and healthy volunteers. These samples are valuable to many research studies within the Hematology Branch of the National Heart, Lung, and Blood Institute, including studies of normal and abnormal production of blood cells, the viral causes of blood diseases, and the role of the immune system in bone marrow failure and related conditions....

Conditions

Bone Marrow Diseases; Healthy Volunteers

Keywords

Bone Marrow; Hematopoiesis; DNA; RNA; Viruses

Outcome Measures

Primary Outcomes (1)

• To provide a readily available supply of samples for blood and bone marrow for in vitro studies in the Hematology Branch laboratories

  The collection of adequate cells for laboratory research.

  Ongoing

Study Arms (1)

Group 1

Normal Volunteers and patients.

Eligibility Criteria

• Age: 2 Years - 110 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Normal Volunteers and patients

You may qualify if:

• Healthy volunteers age greater than or equal to 18 years.
• Subjects with hematologic disease age greater than or equal to 2 (for subjects less than 18, blood and bone marrow specimens will be obtained concurrently with clinically indicated sampling).

You may not qualify if:

• History of a significant bleeding disorder.
• Abnormal host-defense mechanisms.

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI): lead

Study Sites (1)

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Location

Related Links

• NIH Clinical Center Detailed Web Page

MeSH Terms

Conditions

Bone Marrow Diseases; Virus Diseases

Condition Hierarchy (Ancestors)

Hematologic Diseases; Hemic and Lymphatic Diseases; Infections

Study Officials

• Neal S Young, M.D.

  National Heart, Lung, and Blood Institute (NHLBI)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 3, 1999
• First Posted: November 4, 1999
• Study Start: July 8, 1997
• Primary Completion: December 22, 2010
• Study Completion: December 22, 2010
• Last Updated: October 8, 2020

Record last verified: 2020-10

Locations

US (1)