NCT00001624|CompletedPhase 1
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Sponsor study identifier
Secondary identifiers
interventional
16
1 country
1
Study Start
March 1997
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
Not reported
Date not reportedStudy Completion
March 2000
Date type not reportedThis date has not been verified as actual or estimated.
Previous studies have shown that insulin may stimulate the release of endothelin (ET) from endothelial cells. This mechanism may contribute to the adverse vascular effects determined by chronic hyperinsulinemia. The aim of this study will be to evaluate the effect of local hyperinsulinemia on ET activity in the forearm circulation. To this purpose, we will assess the forearm blood flow response to ET receptor antagonism in control conditions and during intraarterial infusion of insulin. We will also measure changes in plasma ET-1 levels in response to the different pharmacological stimuli.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
March 2000
Date type not reportedThis date has not been verified as actual or estimated.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
March 1997
Date type not reportedThis date has not been verified as actual or estimated.
November 3, 1999
Actual (reported)March 2000
Date type not reportedThis date has not been verified as actual or estimated.
December 10, 2002
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National Heart, Lung and Blood Institute (NHLBI)
Bethesda, Maryland, 20892, United States
Haynes WG, Webb DJ. Contribution of endogenous generation of endothelin-1 to basal vascular tone. Lancet. 1994 Sep 24;344(8926):852-4. doi: 10.1016/s0140-6736(94)92827-4.
Donckier J, Stoleru L, Hayashida W, Van Mechelen H, Selvais P, Galanti L, Clozel JP, Ketelslegers JM, Pouleur H. Role of endogenous endothelin-1 in experimental renal hypertension in dogs. Circulation. 1995 Jul 1;92(1):106-13. doi: 10.1161/01.cir.92.1.106.
First Submitted
November 3, 1999
First Posted
December 10, 2002
Study Start
March 1997
Date type not reportedThis date has not been verified as actual or estimated.
Study Completion
March 2000
Date type not reportedThis date has not been verified as actual or estimated.
Last Updated
March 4, 2008
Record last verified: 1999-02
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Source: ClinicalTrials.gov.
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