Magnetic Resonance Imaging at Different Levels of Magnetic Intensity

NCT00001619 | Completed

• 2 other identifiers: 97002697-H-0026
• Study Type: observational
• Target: 497
• Locations: 1 country
• Sites: 1

Brief Summary

Magnetic resonance imaging (MRI) is a diagnostic tool that creates high quality images of the human body without the use of X-ray (radiation). MRI uses different levels of magnetic fields to create images of the body and organs. Occasionally, researchers will give patients undergoing a MRI an injection of a substance called gadolinium. Gadolinium works by brightening areas of the magnetic resonance image, thereby improving the contrast. In this study researchers will use magnetic resonance imaging and contrast substances, like gadolinium, on normal volunteers in order to evaluate different aspects of its performance. Information gathered from this study may be used to develop more specific research studies involving MRI.

Conditions

Cardiovascular Disease; Healthy

Keywords

Imaging; Spectroscopy; MRI; Cardiovascular; Technical Development; Heart; Safety; Toxicity; Gadolinium; Adverse Events; Normal Volunteer

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Any normal volunteer greater than or equal to 18 who is capable of giving informed consent.

You may not qualify if:

• A subject will be excluded if he/she has a contraindication to MR scanning such as:
• Brain aneurysm clip
• Implanted neural stimulator
• Implanted cardiac pacemaker or defibrillator
• Cochlear or ear implant
• Ocular foreign body (e.g. metal shavings)
• Insulin pump
• Pregnant women (when uncertain, subject will undergo urine or blood testing).
• Claustrophobia
• Any condition in the Principal Investigator's judgement which present unnecessary risk
• Lactating Women
• Renal or hepatic disease

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI): lead

Study Sites (1)

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

• Mattay VS, Weinberger DR, Barrios FA, Sobering GS, Kotrla KJ, van Gelderen P, Duyn JH, Sexton RH, Moonen CT, Frank JA. Brain mapping with functional MR imaging: comparison of gradient-echo--based exogenous and endogenous contrast techniques. Radiology. 1995 Mar;194(3):687-91. doi: 10.1148/radiology.194.3.7862963.

  PMID: 7862963 BACKGROUND

• Niendorf HP, Dinger JC, Haustein J, Cornelius I, Alhassan A, Clauss W. Tolerance data of Gd-DTPA: a review. Eur J Radiol. 1991 Jul-Aug;13(1):15-20. doi: 10.1016/0720-048x(91)90049-2.

  PMID: 1889423 BACKGROUND

• Frank JA, Mattay VS, Duyn J, Sobering G, Barrios FA, Zigun J, Sexton R, Kwok P, Woo J, Moonen C, et al. Measurement of relative cerebral blood volume changes with visual stimulation by 'double-dose' gadopentetate-dimeglumine-enhanced dynamic magnetic resonance imaging. Invest Radiol. 1994 Jun;29 Suppl 2:S157-60. doi: 10.1097/00004424-199406001-00052. No abstract available.

  PMID: 7928216 BACKGROUND

MeSH Terms

Conditions

Cardiovascular Diseases

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: November 3, 1999
• First Posted: November 4, 1999
• Study Start: November 5, 1996
• Study Completion: July 20, 2011
• Last Updated: July 2, 2017

Record last verified: 2011-07-20

Locations

US (1)