Genetic Factors and Interrelationships for Cancer Risk-Related Behaviors and Complex Traits

NCT00001500 | Completed

• 2 other identifiers: 96006196-C-0061
• Study Type: observational
• Target: 4,500
• Locations: 1 country
• Sites: 1

Brief Summary

We propose to conduct a multifactorial genetic study of cancer risk-related behaviors and other complex human characteristics. The main areas of interest are tobacco smoking, excess alcohol consumption, psychological traits, and HIV/AIDS susceptibility and progression. The subjects will be adult male and female probands who display one or more of the phenotypes of interest together with their brothers, sisters and parents. Information on tobacco and alcohol use, psychological and personality traits, sexual behavior, HIV status and progression, and other characteristics with possible genetic components will be obtained through structured interviews and questionnaires. DNA will be prepared from blood samples and typed for a series of candidate genes chosen for function and for random polymorphic markers. By correlating the genotypic and phenotypic information, we hope to identify individual loci that interactively contribute to many different aspects of human health and disease.

Conditions

Acquired Immunodeficiency Syndrome; Alcoholism; HIV Infection; Neoplasm; Smoking

Keywords

Smoking; Alcohol; HIV; AIDS; DNA Markers; Personality; Healthy Volunteers; Normal Volunteer

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• The basic requirement for entry in the study will be the presence of any individual smoker who is willing to complete the evaluation process and donate a blood sample.
• Additional siblings will be encouraged but not required to participate.
• Probands will be recruited through smoking cessation programs at the National Naval Medical Center.
• Attendees at programs offered by the Health Promotions Department and the Military Family Health Center will be invited to participate in this study.

You may not qualify if:

• All subjects will be adults (greater than 18 years).

Sponsors & Collaborators

• National Cancer Institute (NCI): lead

Study Sites (1)

National Cancer Institute (NCI)

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

• Carmelli D, Swan GE, Robinette D, Fabsitz RR. Heritability of substance use in the NAS-NRC Twin Registry. Acta Genet Med Gemellol (Roma). 1990;39(1):91-8. doi: 10.1017/s0001566000005602.

  PMID: 2392895 BACKGROUND

• Carmelli D, Swan GE, Robinette D, Fabsitz R. Genetic influence on smoking--a study of male twins. N Engl J Med. 1992 Sep 17;327(12):829-33. doi: 10.1056/NEJM199209173271201.

  PMID: 1508241 BACKGROUND

• Swan GE, Carmelli D, Rosenman RH, Fabsitz RR, Christian JC. Smoking and alcohol consumption in adult male twins: genetic heritability and shared environmental influences. J Subst Abuse. 1990;2(1):39-50. doi: 10.1016/s0899-3289(05)80044-6.

  PMID: 2136102 BACKGROUND

MeSH Terms

Conditions

Acquired Immunodeficiency Syndrome; Alcoholism; HIV Infections; Neoplasms; Smoking

Condition Hierarchy (Ancestors)

Blood-Borne Infections; Communicable Diseases; Infections; Sexually Transmitted Diseases, Viral; Sexually Transmitted Diseases; Lentivirus Infections; Retroviridae Infections; RNA Virus Infections; Virus Diseases; Slow Virus Diseases; Genital Diseases; Urogenital Diseases; Immunologic Deficiency Syndromes; Immune System Diseases; Alcohol-Related Disorders; Substance-Related Disorders; Chemically-Induced Disorders; Mental Disorders; Behavior

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: November 3, 1999
• First Posted: November 4, 1999
• Study Start: April 1, 1996
• Study Completion: July 1, 2004
• Last Updated: March 4, 2008

Record last verified: 2004-07

Locations

US (1)