Diagnosing and Treating Low Blood Sugar Levels
Fasting Hypoglycemia: Diagnosis and Treatment
2 other identifiers
observational
1,500
1 country
1
Brief Summary
Hypoglycemia is the term used to refer to lower than normal levels of blood sugar. This study will continue to research the causes of hypoglycemia. Patients involved in the study will be admitted to the Clinical Center of the National Institutes of Health and undergo tests for evaluating blood sugar. Patients will be required to refrain from eating for a set period of time and will undergo blood tests for insulin levels and several other specific diagnostic tests related to insulin secretion. The patients will be under supervision and will be provided with appropriate medical and surgical attention as needed.
Trial Health
Trial Health Score
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participants targeted
Target at P75+ for all trials
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Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 21, 1991
CompletedFirst Submitted
Initial submission to the registry
November 3, 1999
CompletedFirst Posted
Study publicly available on registry
November 4, 1999
CompletedMay 7, 2026
November 7, 2025
November 3, 1999
May 6, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Treatment Outcomes
resolution of hypoglycemia
every 1-3 months
Study Arms (1)
Patients with hypoglycemia
Patients with hypoglycemia due to diverse etiologies.
Eligibility Criteria
Patients how are referred to us that have fasting hypoglycemia due to diverse etiologies.@@@@@@
You may qualify if:
- In order to be eligible to participate in this study, an individual must meet all of the following criteria:
- Male, females ages \>= 18.
- Patients with documented fasting blood glucose below 55 mg/dl.
- \. Patients with biochemical evidence for insulinoma or other pancreatic neuroendocrine tumors.
You may not qualify if:
- An individual who meets any of the following criteria will be excluded from participation in this study:
- Patients with significant cardiac disease will be excluded.
- Subjects who are pregnant per self-report.
- Medically unstable per the assessment of the PI.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
National Institutes of Health Clinical Center
Bethesda, Maryland, 20892, United States
Related Publications (3)
Bar RS, Gorden P, Roth J, Siebert CW. Insulin receptors in patients with insulinomas: changes in receptor affinity and concentration. J Clin Endocrinol Metab. 1977 Jun;44(6):1210-3. doi: 10.1210/jcem-44-6-1210.
PMID: 194912BACKGROUNDBlackshear PJ, Rotner HE, Kriauciunas KA, Kahn CR. Reactive hypoglycemia and insulin autoantibodies in drug-induced lupus erythematosus. Ann Intern Med. 1983 Aug;99(2):182-4. doi: 10.7326/0003-4819-99-2-182.
PMID: 6349454BACKGROUNDComi RJ, Gorden P. Approach to hypoglycemia in adults. Compr Ther. 1987 Mar;13(3):38-44. No abstract available.
PMID: 3568598BACKGROUND
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Ranganath Muniyappa, M.D.
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- NIH
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
November 3, 1999
First Posted
November 4, 1999
Study Start
May 21, 1991
Last Updated
May 7, 2026
Record last verified: 2025-11-07
Data Sharing
- IPD Sharing
- Will not share