Brain Study of Patients With Frontal Lobe Dementia and Parkinsonian Disorders

NCT00001178 | Terminated

• 2 other identifiers: 81001081-N-0010
• Study Type: observational
• Target: 597
• Locations: 1 country
• Sites: 1

Brief Summary

The Cognitive Neuroscience Section of the National Institute of Neurological Disorders and Stroke proposes to continue its cross-sectional and longitudinal studies of cerebral metabolism in frontal lobe dementias and atypical basal ganglia disorders. These studies include repeated assessments of neuropsychological and brain anatomical and metabolic function in subjects with these important and possibly related brain disorders.

Conditions

Alzheimer's Disease; Dementia; Down's Syndrome

Keywords

Alzheimer's Disease; Cerebral Metabolism; Cerebrospinal Fluid; Dementia of the Alzheimer Type; 18-F-Fluoro-2-Deoxy-D-Glucose (FDG); Magnetic Resonance Imaging; Positron Emission Tomography; X-Ray Computed Tomography (CT); Senile Dementia; Down Syndrome; Trisomy 21

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Diagnosis of possible / probable FTD or CBS
• Caregiver willing and able to accept the responsibilities involved in the study

You may not qualify if:

• Pregnant women. Women of childbearing potential will be screened by history for the possibility of pregnancy and undergo a urine pregnancy test. These women will be excluded from the imaging portions of the protocol.
• Behavioral symptoms that would preclude the gathering of data for the study
• Other medical or social condition that would preclude participation in the opinion of the investigators

Sponsors & Collaborators

• National Institute of Neurological Disorders and Stroke (NINDS): lead

Study Sites (1)

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

• Schwartz M, Creasey H, Grady CL, DeLeo JM, Frederickson HA, Cutler NR, Rapoport SI. Computed tomographic analysis of brain morphometrics in 30 healthy men, aged 21 to 81 years. Ann Neurol. 1985 Feb;17(2):146-57. doi: 10.1002/ana.410170208.

  PMID: 3872096 BACKGROUND

• Schlageter NL, Horwitz B, Creasey H, Carson R, Duara R, Berg GW, Rapoport SI. Relation of measured brain glucose utilisation and cerebral atrophy in man. J Neurol Neurosurg Psychiatry. 1987 Jun;50(6):779-85. doi: 10.1136/jnnp.50.6.779.

  PMID: 3497229 BACKGROUND

• Duara R, Grady C, Haxby J, Ingvar D, Sokoloff L, Margolin RA, Manning RG, Cutler NR, Rapoport SI. Human brain glucose utilization and cognitive function in relation to age. Ann Neurol. 1984 Dec;16(6):703-13. doi: 10.1002/ana.410160613.

  PMID: 6335379 BACKGROUND

MeSH Terms

Conditions

Alzheimer Disease; Dementia; Down Syndrome

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tauopathies; Neurodegenerative Diseases; Neurocognitive Disorders; Mental Disorders; Intellectual Disability; Neurobehavioral Manifestations; Neurologic Manifestations; Abnormalities, Multiple; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Chromosome Disorders; Genetic Diseases, Inborn

Study Officials

• Eric M Wassermann, M.D.

  National Institute of Neurological Disorders and Stroke (NINDS)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: November 3, 1999
• First Posted: November 4, 1999
• Study Start: January 19, 1981
• Study Completion: December 17, 2012
• Last Updated: December 12, 2019

Record last verified: 2012-12-17

Locations

US (1)