NCT00001158

Brief Summary

The goal of the protocol is to define the normal humoral and cellular immune responses to antigens in volunteers and to define abnormalities of these immune responses in patients with immunodeficiency diseases or cancer. In vitro assays and in vivo skin tests and immunization with antigens will be utilized.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Timeline
Completed

Started Apr 1977

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 1977

Completed
22.6 years until next milestone

First Submitted

Initial submission to the registry

November 3, 1999

Completed
4 months until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2000

Completed
2.8 years until next milestone

First Posted

Study publicly available on registry

December 10, 2002

Completed
Last Updated

March 5, 2008

Status Verified

April 1, 1999

First QC Date

November 3, 1999

Last Update Submit

March 4, 2008

Conditions

Immunologic Deficiency SyndromesNeoplasms

Keywords

Cellular ImmunityHumoral ImmunityImmunodeficiency Disease

Eligibility Criteria

Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Patients will be studied if a disorder of the immune system is suspected.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Study Sites (1)

National Cancer Institute (NCI)

Bethesda, Maryland, 20892, United States

Location

Related Publications (1)

  • Nelson DL, Blaese RM, Strober W, Bruce R, Waldmann TA. Constrictive pericarditis, intestinal lymphangiectasia, and reversible immunologic deficiency. J Pediatr. 1975 Apr;86(4):548-54. doi: 10.1016/s0022-3476(75)80145-4.

    PMID: 1127501BACKGROUND

MeSH Terms

Conditions

Immunologic Deficiency SyndromesNeoplasms

Condition Hierarchy (Ancestors)

Immune System Diseases

Study Design

Study Type
observational
Sponsor Type
NIH

Study Record Dates

First Submitted

November 3, 1999

First Posted

December 10, 2002

Study Start

April 1, 1977

Study Completion

March 1, 2000

Last Updated

March 5, 2008

Record last verified: 1999-04

Locations

US(1)