Assessment of Patients With Multiple Sclerosis (MS)

NCT00001156 | Completed

• 2 other identifiers: 76002176-N-0021
• Study Type: observational
• Target: 1,388
• Locations: 1 country
• Sites: 1

Brief Summary

Multiple sclerosis (MS) is a disease of the nervous system. The exact cause of MS is unknown, but it is believed to be an autoimmune condition. Autoimmune conditions are diseases that cause the body's immune system and natural defenses to attack healthy cells. In the case of MS, the immune system begins attacking myelin, the cells that make up the sheath covering nerves. Without myelin, nerves are unable to transmit signals effectively and symptoms occur. This study is directed toward a better understanding of the cause of Multiple Sclerosis (MS). Researchers will evaluate patients with a tentative diagnosis of MS or other neurological diseases possibly caused by a immunological reaction. Patients will undergo a series of three MRIs, taken once a month for three months and submit blood samples for immunological studies.

Conditions

Herpesviridae Infection; HTLV-I Infection; Multiple Sclerosis; Tropical Spastic Paraparesis; Vasculitis

Keywords

Immunogenetics; Tropical Spastic Paraplegia; Twins; Epstein-Barr Virus; HTLV-I; Vasculitis; Cerebrospinal Fluid; Immunity to Viruses; Multiple Sclerosis; Magnetic Resonance Imaging

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Diagnosis of possible MS.
• Age between 18 and 75.

You may not qualify if:

• Clinically significant medical condition other than MS that could cause neurological dysfunction.
• Currently enrolled in an experimental study.
• Medical contraindication for MRI.
• Psychological contraindications for MRI.
• Unable to provide informed consent.

Sponsors & Collaborators

• National Institute of Neurological Disorders and Stroke (NINDS): lead

Study Sites (1)

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

• Martin R, McFarland HF, McFarlin DE. Immunological aspects of demyelinating diseases. Annu Rev Immunol. 1992;10:153-87. doi: 10.1146/annurev.iy.10.040192.001101.

  PMID: 1375472 BACKGROUND

• Alexander EL, Beall SS, Gordon B, Selnes OA, Yannakakis GD, Patronas N, Provost TT, McFarland HF. Magnetic resonance imaging of cerebral lesions in patients with the Sjogren syndrome. Ann Intern Med. 1988 Jun;108(6):815-23. doi: 10.7326/0003-4819-108-6-815.

  PMID: 3369771 BACKGROUND

• Beall SS, Concannon P, Charmley P, McFarland HF, Gatti RA, Hood LE, McFarlin DE, Biddison WE. The germline repertoire of T cell receptor beta-chain genes in patients with chronic progressive multiple sclerosis. J Neuroimmunol. 1989 Jan;21(1):59-66. doi: 10.1016/0165-5728(89)90159-8.

  PMID: 2562801 BACKGROUND

MeSH Terms

Conditions

Herpesviridae Infections; HTLV-I Infections; Multiple Sclerosis; Paraparesis, Tropical Spastic; Vasculitis; Epstein-Barr Virus Infections

Condition Hierarchy (Ancestors)

DNA Virus Infections; Virus Diseases; Infections; Deltaretrovirus Infections; Retroviridae Infections; RNA Virus Infections; Immunologic Deficiency Syndromes; Immune System Diseases; Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Myelitis; Central Nervous System Infections; Central Nervous System Diseases; Spinal Cord Diseases; Neuroinflammatory Diseases; Vascular Diseases; Cardiovascular Diseases; Tumor Virus Infections

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: November 3, 1999
• First Posted: November 4, 1999
• Study Start: January 23, 1976
• Study Completion: February 1, 2010
• Last Updated: July 2, 2017

Record last verified: 2010-02-01

Locations

US (1)