Prospective Investigation of Pulmonary Embolism Diagnosis (PIOPED)

NCT00000566 | Completed Phase 3

• 1 other identifier: 204
• Study Type: interventional
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

To evaluate the sensitivity and specificity of two major, widely used technologies, radionuclear imaging (ventilation-perfusion scanning) and pulmonary angiography, for the diagnosis of pulmonary embolism.

Conditions

Lung Diseases; Pulmonary Embolism

Interventions

ventilation-perfusion ratio PROCEDURE

angiography PROCEDURE

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

Men and women suspected of having a pulmonary embolism and who met the criteria to undergo angiography.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI): lead

Related Publications (13)

• Henry JW, Stein PD, Gottschalk A, Raskob GE. Pulmonary embolism among patients with a nearly normal ventilation/perfusion lung scan. Chest. 1996 Aug;110(2):395-8. doi: 10.1378/chest.110.2.395.

  PMID: 8697840 BACKGROUND

• Gottschalk A, Stein PD, Henry JW, Relyea B. Can pulmonary angiography be limited to the most suspicious side if the contralateral side appears normal on the ventilation/perfusion lung scan? Data from PIOPED. Prospective Investigation of Pulmonary Embolism Diagnosis. Chest. 1996 Aug;110(2):392-4. doi: 10.1378/chest.110.2.392.

  PMID: 8697839 BACKGROUND

• Tissue plasminogen activator for the treatment of acute pulmonary embolism. A collaborative study by the PIOPED Investigators. Chest. 1990 Mar;97(3):528-33. doi: 10.1378/chest.97.3.528.

  PMID: 2106408 BACKGROUND

• PIOPED Investigators. Value of the ventilation/perfusion scan in acute pulmonary embolism. Results of the prospective investigation of pulmonary embolism diagnosis (PIOPED). JAMA. 1990 May 23-30;263(20):2753-9. doi: 10.1001/jama.1990.03440200057023.

  PMID: 2332918 BACKGROUND

• Bone RC. Ventilation/perfusion scan in pulmonary embolism. 'The Emperor is incompletely attired'. JAMA. 1990 May 23-30;263(20):2794-5. No abstract available.

  PMID: 2185372 BACKGROUND

• Stein PD, Gottschalk A, Saltzman HA, Terrin ML. Diagnosis of acute pulmonary embolism in the elderly. J Am Coll Cardiol. 1991 Nov 15;18(6):1452-7. doi: 10.1016/0735-1097(91)90674-x.

  PMID: 1939945 BACKGROUND

• Stein PD, Alavi A, Gottschalk A, Hales CA, Saltzman HA, Vreim CE, Weg JG. Usefulness of noninvasive diagnostic tools for diagnosis of acute pulmonary embolism in patients with a normal chest radiograph. Am J Cardiol. 1991 May 15;67(13):1117-20. doi: 10.1016/0002-9149(91)90875-l.

  PMID: 2024602 BACKGROUND

• Stein PD, Coleman RE, Gottschalk A, Saltzman HA, Terrin ML, Weg JG. Diagnostic utility of ventilation/perfusion lung scans in acute pulmonary embolism is not diminished by pre-existing cardiac or pulmonary disease. Chest. 1991 Sep;100(3):604-6. doi: 10.1378/chest.100.3.604.

  PMID: 1889240 BACKGROUND

• Stein PD, Terrin ML, Hales CA, Palevsky HI, Saltzman HA, Thompson BT, Weg JG. Clinical, laboratory, roentgenographic, and electrocardiographic findings in patients with acute pulmonary embolism and no pre-existing cardiac or pulmonary disease. Chest. 1991 Sep;100(3):598-603. doi: 10.1378/chest.100.3.598.

  PMID: 1909617 BACKGROUND

• Stein PD, Saltzman HA, Weg JG. Clinical characteristics of patients with acute pulmonary embolism. Am J Cardiol. 1991 Dec 15;68(17):1723-4. doi: 10.1016/0002-9149(91)90339-m. No abstract available.

  PMID: 1746481 BACKGROUND

• Stein PD, Athanasoulis C, Greenspan RH, Henry JW. Relation of plain chest radiographic findings to pulmonary arterial pressure and arterial blood oxygen levels in patients with acute pulmonary embolism. Am J Cardiol. 1992 Feb 1;69(4):394-6. doi: 10.1016/0002-9149(92)90240-y.

  PMID: 1734655 BACKGROUND

• Quinn DA, Thompson BT, Terrin ML, Thrall JH, Athanasoulis CA, McKusick KA, Stein PD, Hales CA. A prospective investigation of pulmonary embolism in women and men. JAMA. 1992 Oct 7;268(13):1689-96.

  PMID: 1527878 BACKGROUND

• Carson JL, Kelley MA, Duff A, Weg JG, Fulkerson WJ, Palevsky HI, Schwartz JS, Thompson BT, Popovich J Jr, Hobbins TE, et al. The clinical course of pulmonary embolism. N Engl J Med. 1992 May 7;326(19):1240-5. doi: 10.1056/NEJM199205073261902.

  PMID: 1560799 BACKGROUND

MeSH Terms

Conditions

Lung Diseases; Pulmonary Embolism

Interventions

Ventilation-Perfusion Ratio; Cerebral Angiography

Condition Hierarchy (Ancestors)

Respiratory Tract Diseases; Embolism; Embolism and Thrombosis; Vascular Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Pulmonary Gas Exchange; Respiratory Function Tests; Diagnostic Techniques, Respiratory System; Diagnostic Techniques and Procedures; Diagnosis; Respiratory Physiological Phenomena; Circulatory and Respiratory Physiological Phenomena; Neuroradiography; Neuroimaging; Diagnostic Imaging; Angiography; Radiography; Diagnostic Techniques, Cardiovascular; Diagnostic Techniques, Neurological; Investigative Techniques

Study Officials

• Abass Alavi

  University of Pennsylvania

• Richard Greenspan

  Yale University

• Charles Hales

  Massachusetts General Hospital

• Herbert Saltzman

  Duke University

• Paul Stein

  Henry Ford Hospital

• John Weg

  University of Michigan

Study Design

• Study Type: interventional
• Phase: phase 3
• Purpose: DIAGNOSTIC
• Sponsor Type: NIH

Study Record Dates

• First Submitted: October 27, 1999
• First Posted: October 28, 1999
• Study Start: September 1, 1983
• Study Completion: December 1, 1989
• Last Updated: April 15, 2016

Record last verified: 2002-06