NCT00000544

Brief Summary

To test the effectiveness of dietary patterns in lowering blood pressure.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Timeline
Completed

Started Aug 1993

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 1, 1993

Completed
3.9 years until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 1997

Completed
2.3 years until next milestone

First Submitted

Initial submission to the registry

October 27, 1999

Completed
1 day until next milestone

First Posted

Study publicly available on registry

October 28, 1999

Completed
Last Updated

November 7, 2016

Status Verified

October 1, 2005

First QC Date

October 27, 1999

Last Update Submit

November 4, 2016

Conditions

Cardiovascular DiseasesHeart DiseasesHypertensionVascular Diseases

Interventions

diet therapyBEHAVIORAL

Eligibility Criteria

Age22 Years - 100 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Men and women with higher than optimal diastolic blood pressure or with Stage 1 (mild) hypertension.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Related Publications (31)

  • Laws R, Newgard ML. Bridging the gap: using ODBC to grab data stored in a SAS data warehouse for reporting in Microsoft Access. 21st Annual SAS Users Group 1996;724-728.

    BACKGROUND

  • Sacks FM, Obarzanek E, Windhauser MM, Svetkey LP, Vollmer WM, McCullough M, Karanja N, Lin PH, Steele P, Proschan MA, et al. Rationale and design of the Dietary Approaches to Stop Hypertension trial (DASH). A multicenter controlled-feeding study of dietary patterns to lower blood pressure. Ann Epidemiol. 1995 Mar;5(2):108-18. doi: 10.1016/1047-2797(94)00055-x.

    PMID: 7795829BACKGROUND

  • Appel LJ, Moore TJ, Obarzanek E, Vollmer WM, Svetkey LP, Sacks FM, Bray GA, Vogt TM, Cutler JA, Windhauser MM, Lin PH, Karanja N. A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group. N Engl J Med. 1997 Apr 17;336(16):1117-24. doi: 10.1056/NEJM199704173361601.

    PMID: 9099655BACKGROUND

  • Appel LJ, Moore TJ, Obarzanek E. Dietary patterns and blood pressure. N Engl J Med 1997;337:637-638

    BACKGROUND

  • Miller ER 3rd, Appel LJ, Jiang L, Risby TH. Association between cigarette smoking and lipid peroxidation in a controlled feeding study. Circulation. 1997 Aug 19;96(4):1097-101. doi: 10.1161/01.cir.96.4.1097.

    PMID: 9286935BACKGROUND

  • Vollmer WM, Svetkey LP, Appel LJ, Obarzanek E, Reams P, Kennedy B, Aicher K, Charleston J, Conlin PR, Evans M, Harsha D, Hertert S. Recruitment and retention of minority participants in the DASH controlled feeding trial. DASH Collaborative Research Group. Dietary Approaches to Stop Hypertension. Ethn Dis. 1998;8(2):198-208.

    PMID: 9681285BACKGROUND

  • Zemel MB. Dietary pattern and hypertension: the DASH study. Dietary Approaches to Stop Hypertension. Nutr Rev. 1997 Aug;55(8):303-5. doi: 10.1111/j.1753-4887.1997.tb05489.x. No abstract available.

    PMID: 9287480BACKGROUND

  • Blackburn GL. Functional foods in the prevention and treatment of disease: significance of the Dietary Approaches to Stop Hypertension Study. Am J Clin Nutr. 1997 Nov;66(5):1067-71. doi: 10.1093/ajcn/66.5.1067. No abstract available.

    PMID: 9356522BACKGROUND

  • Svetkey LP, Simons-Morton D, Vollmer WM, Appel LJ, Conlin PR, Ryan DH, Ard J, Kennedy BM. Effects of dietary patterns on blood pressure: subgroup analysis of the Dietary Approaches to Stop Hypertension (DASH) randomized clinical trial. Arch Intern Med. 1999 Feb 8;159(3):285-93. doi: 10.1001/archinte.159.3.285.

    PMID: 9989541BACKGROUND

  • Moore TJ, Vollmer WM, Appel LJ, Sacks FM, Svetkey LP, Vogt TM, Conlin PR, Simons-Morton DG, Carter-Edwards L, Harsha DW. Effect of dietary patterns on ambulatory blood pressure : results from the Dietary Approaches to Stop Hypertension (DASH) Trial. DASH Collaborative Research Group. Hypertension. 1999 Sep;34(3):472-7. doi: 10.1161/01.hyp.34.3.472.

    PMID: 10489396BACKGROUND

  • Windhauser MM, Ernst DB, Karanja NM, Crawford SW, Redican SE, Swain JF, Karimbakas JM, Champagne CM, Hoben KP, Evans MA. Translating the Dietary Approaches to Stop Hypertension diet from research to practice: dietary and behavior change techniques. DASH Collaborative Research Group. J Am Diet Assoc. 1999 Aug;99(8 Suppl):S90-5. doi: 10.1016/s0002-8223(99)00422-8.

    PMID: 10450300BACKGROUND

  • Plaisted CS, Lin PH, Ard JD, McClure ML, Svetkey LP. The effects of dietary patterns on quality of life: a substudy of the Dietary Approaches to Stop Hypertension trial. J Am Diet Assoc. 1999 Aug;99(8 Suppl):S84-9. doi: 10.1016/s0002-8223(99)00421-6.

    PMID: 10450299BACKGROUND

  • Windhauser MM, Evans MA, McCullough ML, Swain JF, Lin PH, Hoben KP, Plaisted CS, Karanja NM, Vollmer WM. Dietary adherence in the Dietary Approaches to Stop Hypertension trial. DASH Collaborative Research Group. J Am Diet Assoc. 1999 Aug;99(8 Suppl):S76-83. doi: 10.1016/s0002-8223(99)00420-4.

    PMID: 10450298BACKGROUND

  • Appel LJ, Vollmer WM, Obarzanek E, Aicher KM, Conlin PR, Kennedy BM, Charleston JB, Reams PM. Recruitment and baseline characteristics of participants in the Dietary Approaches to Stop Hypertension trial. DASH Collaborative Research Group. J Am Diet Assoc. 1999 Aug;99(8 Suppl):S69-75. doi: 10.1016/s0002-8223(99)00419-8.

    PMID: 10450297BACKGROUND

  • Phillips KM, Stewart KK, Karanja NM, Windhauser MM, Champagne CM, Swain JF, Lin PH, Evans MA. Validation of diet composition for the Dietary Approaches to Stop Hypertension trial. DASH Collaborative Research Group. J Am Diet Assoc. 1999 Aug;99(8 Suppl):S60-8. doi: 10.1016/s0002-8223(99)00418-6.

    PMID: 10450296BACKGROUND

  • Swain JF, Windhauser MM, Hoben KP, Evans MA, McGee BB, Steele PD. Menu design and selection for multicenter controlled feeding studies: process used in the Dietary Approaches to Stop Hypertension trial. DASH Collaborative Research Group. J Am Diet Assoc. 1999 Aug;99(8 Suppl):S54-9. doi: 10.1016/s0002-8223(99)00417-4.

    PMID: 10450295BACKGROUND

  • McCullough ML, Karanja NM, Lin PH, Obarzanek E, Phillips KM, Laws RL, Vollmer WM, O'Connor EA, Champagne CM, Windhauser MM. Comparison of 4 nutrient databases with chemical composition data from the Dietary Approaches to Stop Hypertension trial. DASH Collaborative Research Group. J Am Diet Assoc. 1999 Aug;99(8 Suppl):S45-53. doi: 10.1016/s0002-8223(99)00416-2.

    PMID: 10450294BACKGROUND

  • Lin PH, Windhauser MM, Plaisted CS, Hoben KP, McCullough ML, Obarzanek E. The Linear Index Model for establishing nutrient goals in the Dietary Approaches to Stop Hypertension trial. DASH Collaborative Research Group. J Am Diet Assoc. 1999 Aug;99(8 Suppl):S40-4. doi: 10.1016/s0002-8223(99)00415-0.

    PMID: 10450293BACKGROUND

  • Harsha DW, Lin PH, Obarzanek E, Karanja NM, Moore TJ, Caballero B. Dietary Approaches to Stop Hypertension: a summary of study results. DASH Collaborative Research Group. J Am Diet Assoc. 1999 Aug;99(8 Suppl):S35-9. doi: 10.1016/s0002-8223(99)00414-9.

    PMID: 10450292BACKGROUND

  • Karanja NM, McCullough ML, Kumanyika SK, Pedula KL, Windhauser MM, Obarzanek E, Lin PH, Champagne CM, Swain JF. Pre-enrollment diets of Dietary Approaches to Stop Hypertension trial participants. DASH Collaborative Research Group. J Am Diet Assoc. 1999 Aug;99(8 Suppl):S28-34. doi: 10.1016/s0002-8223(99)00413-7.

    PMID: 10450291BACKGROUND

  • Karanja NM, Obarzanek E, Lin PH, McCullough ML, Phillips KM, Swain JF, Champagne CM, Hoben KP. Descriptive characteristics of the dietary patterns used in the Dietary Approaches to Stop Hypertension Trial. DASH Collaborative Research Group. J Am Diet Assoc. 1999 Aug;99(8 Suppl):S19-27. doi: 10.1016/s0002-8223(99)00412-5.

    PMID: 10450290BACKGROUND

  • Vogt TM, Appel LJ, Obarzanek E, Moore TJ, Vollmer WM, Svetkey LP, Sacks FM, Bray GA, Cutler JA, Windhauser MM, Lin PH, Karanja NM. Dietary Approaches to Stop Hypertension: rationale, design, and methods. DASH Collaborative Research Group. J Am Diet Assoc. 1999 Aug;99(8 Suppl):S12-8. doi: 10.1016/s0002-8223(99)00411-3.

    PMID: 10450289BACKGROUND

  • Obarzanek E, Moore TJ. Using feeding studies to test the efficacy of dietary interventions: lessons from the Dietary Approaches to Stop Hypertension trial. J Am Diet Assoc. 1999 Aug;99(8 Suppl):S9-11. doi: 10.1016/s0002-8223(99)00409-5. No abstract available.

    PMID: 10450288BACKGROUND

  • Sacks FM, Appel LJ, Moore TJ, Obarzanek E, Vollmer WM, Svetkey LP, Bray GA, Vogt TM, Cutler JA, Windhauser MM, Lin PH, Karanja N. A dietary approach to prevent hypertension: a review of the Dietary Approaches to Stop Hypertension (DASH) Study. Clin Cardiol. 1999 Jul;22(7 Suppl):III6-10. doi: 10.1002/clc.4960221503.

    PMID: 10410299BACKGROUND

  • Conlin PR, Chow D, Miller ER 3rd, Svetkey LP, Lin PH, Harsha DW, Moore TJ, Sacks FM, Appel LJ. The effect of dietary patterns on blood pressure control in hypertensive patients: results from the Dietary Approaches to Stop Hypertension (DASH) trial. Am J Hypertens. 2000 Sep;13(9):949-55. doi: 10.1016/s0895-7061(99)00284-8.

    PMID: 10981543BACKGROUND

  • Getchell WS, Svetkey LP, Appel LJ, Moore TJ, Bray GA, Obarzanek E. Summary of the Dietary Approaches to Stop Hypertension (DASH) Randomized Clinical Trial. Curr Treat Options Cardiovasc Med. 1999 Dec;1(4):295-300. doi: 10.1007/s11936-999-0024-6. No abstract available.

    PMID: 11096495BACKGROUND

  • Obarzanek E, Sacks FM, Vollmer WM, Bray GA, Miller ER 3rd, Lin PH, Karanja NM, Most-Windhauser MM, Moore TJ, Swain JF, Bales CW, Proschan MA; DASH Research Group. Effects on blood lipids of a blood pressure-lowering diet: the Dietary Approaches to Stop Hypertension (DASH) Trial. Am J Clin Nutr. 2001 Jul;74(1):80-9. doi: 10.1093/ajcn/74.1.80.

    PMID: 11451721BACKGROUND

  • Vollmer WM, Appel LJ, Svetkey LP, Moore TJ, Vogt TM, Conlin PR, Proschan M, Harsha D; DASH Collaborative Research Group. Comparing office-based and ambulatory blood pressure monitoring in clinical trials. J Hum Hypertens. 2005 Jan;19(1):77-82. doi: 10.1038/sj.jhh.1001772.

    PMID: 15361888BACKGROUND

  • Juraschek SP, Yokose C, McCormick N, Miller ER 3rd, Appel LJ, Choi HK. Effects of Dietary Patterns on Serum Urate: Results From a Randomized Trial of the Effects of Diet on Hypertension. Arthritis Rheumatol. 2021 Jun;73(6):1014-1020. doi: 10.1002/art.41614. Epub 2021 Apr 23.

    PMID: 33615722DERIVED

  • Juraschek SP, Kovell LC, Appel LJ, Miller ER 3rd, Sacks FM, Christenson RH, Rebuck H, Chang AR, Mukamal KJ. Associations Between Dietary Patterns and Subclinical Cardiac Injury: An Observational Analysis From the DASH Trial. Ann Intern Med. 2020 Jun 16;172(12):786-794. doi: 10.7326/M20-0336. Epub 2020 May 19.

    PMID: 32423348DERIVED

  • Chen ST, Maruthur NM, Appel LJ. The effect of dietary patterns on estimated coronary heart disease risk: results from the Dietary Approaches to Stop Hypertension (DASH) trial. Circ Cardiovasc Qual Outcomes. 2010 Sep;3(5):484-9. doi: 10.1161/CIRCOUTCOMES.109.930685. Epub 2010 Aug 31.

    PMID: 20807884DERIVED

Related Links

MeSH Terms

Conditions

Cardiovascular DiseasesHeart DiseasesHypertensionVascular Diseases

Interventions

Diet Therapy

Intervention Hierarchy (Ancestors)

Nutrition TherapyTherapeutics

Study Officials

  • William Vollmer

    Kaiser Foundation Research Institute

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Purpose
TREATMENT
Sponsor Type
NIH

Study Record Dates

First Submitted

October 27, 1999

First Posted

October 28, 1999

Study Start

August 1, 1993

Study Completion

July 1, 1997

Last Updated

November 7, 2016

Record last verified: 2005-10