Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

Moderate Risk

Score: 50/100

Failure Rate

27.3%

3 terminated/withdrawn out of 11 trials

Success Rate

72.7%

-13.8% vs industry average

Late-Stage Pipeline

73%

8 trials in Phase 3/4

Results Transparency

88%

7 of 8 completed trials have results

Key Signals

7 with results

Enrollment Performance

Analytics

Phase 3
7(77.8%)
Phase 4
1(11.1%)
Phase 1
1(11.1%)
9Total
Phase 3(7)
Phase 4(1)
Phase 1(1)

Activity Timeline

Global Presence

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Clinical Trials (11)

Showing 11 of 11 trials
NCT03936777Phase 3Completed

A Study to Investigate the Long-Term Safety of ZX008 (Fenfluramine Hydrochloride) Oral Solution in Children and Adults With Epileptic Encephalopathy Including Dravet Syndrome and Lennox-Gastaut Syndrome

Role: collaborator

NCT02823145Phase 3Completed

An Open-Label Extension Trial to Assess the Long-Term Safety of ZX008 (Fenfluramine Hydrochloride HCl) Oral Solution in Children and Young Adults With Dravet Syndrome

Role: lead

NCT03355209Phase 3Completed

A Study to Investigate the Efficacy and Safety of ZX008 (Fenfluramine Hydrochloride) as an Adjunctive Therapy in Children and Adults With Lennox-Gastaut Syndrome

Role: lead

NCT03790137Phase 3Completed

Treatment of Sunflower Syndrome With ZX008 (Fenfluramine Hydrochloride) in Children and Young Adults (Ages 4-25).

Role: collaborator

NCT05140122Withdrawn

LEONIDaS Caregivers Study

Role: collaborator

NCT03467113Phase 1Completed

A Study to Assess the Safety and Tolerability of ZX008 in Children and Young Adults With Dravet Syndrome or Lennox Gastaut Syndrome Currently Taking Cannabidiol

Role: lead

NCT04398667Terminated

European Non-interventional Study on Refractory Epilepsy With Developmental Delay

Role: collaborator

NCT03299842Phase 3Terminated

A Study to Assess the Usability of the Embrace Seizure Detection Watch in Children and Young Adults With Dravet Syndrome

Role: lead

NCT02682927Phase 3Completed

A Trial of Two Fixed Doses of ZX008 (Fenfluramine HCl) in Children and Young Adults With Dravet Syndrome

Role: lead

NCT05026398Phase 4Completed

Fenfluramine and Cognition

Role: collaborator

NCT02926898Phase 3Completed

A 2-Part Study to Investigate the Dose-Ranging Safety and Pharmacokinetics, Followed by the Efficacy and Safety of ZX008 (Fenfluramine Hydrochloride) Oral Solution as an Adjunctive Therapy in Children ≥ 2 Years Old and Young Adults With Dravet Syndrome

Role: lead

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