Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

Low Risk

Score: 30/100

Failure Rate

8.7%

2 terminated/withdrawn out of 23 trials

Success Rate

85.7%

-0.8% vs industry average

Late-Stage Pipeline

48%

11 trials in Phase 3/4

Results Transparency

50%

6 of 12 completed trials have results

Key Signals

5 recruiting6 with results

Enrollment Performance

Analytics

Phase 3
11(47.8%)
Phase 1
8(34.8%)
Phase 2
4(17.4%)
23Total
Phase 3(11)
Phase 1(8)
Phase 2(4)

Activity Timeline

Global Presence

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Clinical Trials (23)

Showing 20 of 23 trials
NCT07172516Phase 3Recruiting

A Randomized Study of Azetukalner Versus Placebo in Depressive Episodes Associated With Bipolar I or II Disorder (Bipolar Depression)

Role: lead

NCT05718817Phase 3Enrolling By Invitation

An Open-label Study of XEN1101 in Epilepsy

Role: lead

NCT07076407Phase 3Recruiting

A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3)

Role: lead

NCT05614063Phase 3Completed

A Randomized Study of XEN1101 Versus Placebo in Focal-Onset Seizures

Role: lead

NCT05716100Phase 3Recruiting

A Randomized Study of XEN1101 Versus Placebo in Focal-Onset Seizures (X-TOLE3)

Role: lead

NCT05667142Phase 3Recruiting

A Study to Evaluate XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures

Role: lead

NCT07217860Phase 3Enrolling By Invitation

An Open-label Study of Azetukalner in Bipolar I or II Depression (X-CEED-OLE)

Role: lead

NCT06922110Phase 3Enrolling By Invitation

An Open-Label Study of Azetukalner in Major Depressive Disorder

Role: lead

NCT06775379Phase 3Recruiting

A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder

Role: lead

NCT04912856Phase 3Terminated

An Open-Label Extension of the Study XEN496 (Ezogabine) in Children With KCNQ2-DEE

Role: lead

NCT03796962Phase 2Active Not Recruiting

A Study to Evaluate XEN1101 as Adjunctive Therapy in Focal Epilepsy

Role: lead

NCT05376150Phase 2Completed

A Study to Evaluate the Safety, Tolerability and Efficacy of XEN1101 in Major Depressive Disorder

Role: lead

NCT04639310Phase 3Terminated

XEN496 (Ezogabine) in Children With KCNQ2 Developmental and Epileptic Encephalopathy

Role: lead

NCT03340220Phase 1Completed

Safety, Tolerability, and Pharmacokinetics (PK) of Single and Multiple Ascending Oral Doses of XEN1101.

Role: lead

NCT04952467Phase 1Completed

Single-dose Mass Balance Recovery and Metabolite Profile and Identification of 14C-XEN1101

Role: lead

NCT03467100Phase 1Completed

Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Oral Doses of XEN901

Role: lead

NCT02656043Phase 1Completed

A Safety, Tolerability, Efficacy and Exposure Study of XEN801 Topical Gel

Role: lead

NCT03468725Phase 1Completed

Safety, Tolerability, Pharmacokinetics and Effects on Transcranial Magnetic Stimulation of Oral Doses of XEN1101

Role: lead

NCT01486446Phase 1Completed

Phase 2a, Exploratory Study to Evaluate the Safety, Efficacy, Tolerability and Pharmacokinetics of XPF-002 in Patients With Primary/Inherited Erythromelalgia

Role: lead

NCT01195636Phase 2Completed

A Crossover Study to Evaluate the Safety, Tolerability and Efficacy of XPF-002 in Subjects With Postherpetic Neuralgia (PHN)

Role: lead