Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

Moderate Risk

Score: 45/100

Failure Rate

8.3%

1 terminated/withdrawn out of 12 trials

Success Rate

87.5%

+1.0% vs industry average

Late-Stage Pipeline

0%

0 trials in Phase 3/4

Results Transparency

0%

0 of 7 completed trials have results

Key Signals

2 recruiting

Enrollment Performance

Analytics

Phase 1
11(91.7%)
Phase 2
1(8.3%)
12Total
Phase 1(11)
Phase 2(1)

Activity Timeline

Global Presence

Loading network data...

Clinical Trials (12)

Showing 12 of 12 trials
NCT03769155Phase 1Active Not Recruiting

VX15/2503 With or Without Ipilimumab and/or Nivolumab in Patients With Resectable Stage IIIB-D Melanoma

Role: collaborator

NCT05378464Phase 1Recruiting

Adoptive T Cell Therapy Following HER2-Pulsed Dendritic Cell Vaccine & Pepinemab /Trastuzumab in Patients w/ Metastatic HER2+ Breast Cancer

Role: collaborator

NCT03690986Phase 1Recruiting

VX15/2503 in Combination With Ipilimumab or Nivolumab in Patients With Head and Neck Cancer

Role: collaborator

NCT05102721Phase 1Active Not Recruiting

Trial of Immunotherapy With Avelumab and Pepinemab As Second Line For Patients With Metastatic Pancreatic Adenocarcinoma

Role: lead

NCT04815720Phase 1Completed

Pepinemab in Combination With Pembrolizumab in Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck

Role: lead

NCT04381468Phase 1Completed

SEMA4D Blockade Safety and Brain Metabolic Activity in Alzheimer's Disease (AD)

Role: lead

NCT03373188Phase 1Completed

VX15/2503 and Immunotherapy in Resectable Pancreatic and Colorectal Cancer

Role: collaborator

NCT03268057Phase 1Completed

VX15/2503 in Combination With Avelumab in Advanced Non-small Cell Lung Cancer

Role: lead

NCT02481674Phase 2Completed

A Study in Subjects With Late Prodromal & Early Manifest HD to Assess the Safety, Tolerability, pk, and Efficacy of Pepi

Role: lead

NCT03425461Phase 1Terminated

Anti-SEMA4D Monoclonal Antibody VX15/2503 With Nivolumab or Ipilimumab in Treating Patients With Stage III or IV Melanoma

Role: collaborator

NCT01764737Phase 1Completed

Evaluation of Safety, Tolerability, and PK of VX15/2503 In Patients With MS

Role: lead

NCT01313065Phase 1Completed

Evaluation of Safety, Tolerability, PK & PD of Intravenous VX15/2503 in Patients With Advanced Solid Tumors

Role: lead

All 12 trials loaded