Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 80/100

Failure Rate

50.0%

5 terminated/withdrawn out of 10 trials

Success Rate

16.7%

-69.8% vs industry average

Late-Stage Pipeline

0%

0 trials in Phase 3/4

Results Transparency

200%

2 of 1 completed trials have results

Key Signals

3 recruiting2 with results

Enrollment Performance

Analytics

Phase 1
10(100.0%)
10Total
Phase 1(10)

Activity Timeline

Global Presence

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Clinical Trials (10)

Showing 10 of 10 trials
NCT04094610Phase 1Recruiting

A Study of Repotrectinib in Pediatric and Young Adult Subjects Harboring ALK, ROS1, OR NTRK1-3 Alterations

Role: lead

NCT03993873Phase 1Active Not Recruiting

Study of TPX-0022 in Patients With Advanced NSCLC, Gastric Cancer or Solid Tumors Harboring Genetic Alterations in MET

Role: lead

NCT03093116Phase 1Recruiting

A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements

Role: lead

NCT05828303Phase 1Withdrawn

A Phase 1 Study to Evaluate the Potential Drug Interactions Between Repotrectinib and Metformin, Digoxin, and Rosuvastatin in Patients With Advanced Solid Tumors

Role: lead

NCT04161391Phase 1Terminated

Study of TPX-0046, A RET/SRC Inhibitor in Adult Subjects With Advanced Solid Tumors Harboring RET Fusions or Mutations

Role: lead

NCT05001516Phase 1Completed

Study of Turning Point Therapeutics LM-302 in Patients With Advance Solid Tumors

Role: lead

NCT04772235Phase 1Recruiting

Phase I Study of Repotrectinib and Osimertinib in NSCLC Patients

Role: collaborator

NCT05071183Phase 1Terminated

A Study of Repotrectinib in Combination With Other Anticancer Therapies for the Treatment of Subjects With KRAS-Mutant Solid Tumors

Role: lead

NCT05828277Phase 1Withdrawn

A Phase 1 Study to Assess the Effect of Hepatic Impairment on the Pharmacokinetics of Repotrectinib in Advanced Cancer Patients

Role: lead

NCT04849273Phase 1Terminated

A Study of TPX-0131, a Novel Oral ALK Tyrosine Kinase Inhibitor, in Patients With ALK+ Advanced or Metastatic NSCLC

Role: lead

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