Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

Low Risk

Score: 25/100

Failure Rate

9.1%

2 terminated/withdrawn out of 22 trials

Success Rate

88.9%

+2.4% vs industry average

Late-Stage Pipeline

5%

1 trials in Phase 3/4

Results Transparency

88%

14 of 16 completed trials have results

Key Signals

14 with results

Enrollment Performance

Analytics

Phase 1
15(71.4%)
Phase 2
5(23.8%)
Phase 3
1(4.8%)
21Total
Phase 1(15)
Phase 2(5)
Phase 3(1)

Activity Timeline

Global Presence

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Clinical Trials (22)

Showing 20 of 22 trials
NCT02520063Phase 1Completed

Combination of Letrozole, Everolimus and TRC105 in Postmenopausal Women With Hormone-Receptor Positive and Her2 Negative Breast Cancer

Role: collaborator

NCT04480502Phase 2Active Not Recruiting

ENVASARC: Envafolimab And Envafolimab With Ipilimumab In Patients With Undifferentiated Pleomorphic Sarcoma Or Myxofibrosarcoma

Role: lead

NCT05448820Phase 1Unknown

YH001 Plus Envafolimab With or Without Doxorubicin in Patients With Advanced or Metastatic Sarcoma

Role: lead

NCT03835949Phase 1Unknown

Study of TJ004309 in Combination With Atezolizumab (Tecentriq®) in Patients With Advanced or Metastatic Cancer

Role: lead

NCT02429843Phase 1Completed

A Study of TRC105 in Combination With Paclitaxel/Carboplatin and Bevacizumab in Non-Squamous Cell Lung Cancer

Role: collaborator

NCT02987829Phase 1Completed

Phase 1/2A Study of TRC253, an Androgen Receptor Antagonist, in Metastatic Castration-resistant Prostate Cancer Patients

Role: lead

NCT02354612Unknown

Open Label Continuation Study of TRC105 for Patients Who Have Completed a Prior TRC105 Trial

Role: lead

NCT01806064Phase 1Terminated

Randomized Phase 2 Trial of Axitinib and TRC105 Versus Axitinib Alone in Patients Renal Cell Carcinoma

Role: lead

NCT02560779Phase 1Completed

Trial of TRC105 and Sorafenib in Patients With HCC

Role: lead

NCT03181308Phase 1Completed

Study of Carotuximab (TRC105) Plus Nivolumab in Patients With Metastatic NSCLC

Role: lead

NCT01975519Phase 1Completed

A Phase 1B Dose-escalation and Phase 2a Study of Carotuximab (TRC105) in Combination With Pazopanib in Patients With Advanced Soft Tissue Sarcoma

Role: lead

NCT02979899Phase 3Completed

Trial of TRC105 and Pazopanib Versus Pazopanib Alone in Patients With Advanced Angiosarcoma

Role: lead

NCT03780010Phase 1Completed

Study of TRC105 + Paclitaxel/Carboplatin and Bevacizumab in Patients With NSCLC

Role: lead

NCT02664961Phase 2Terminated

Study of TRC105 and Bevacizumab in Patients With Refractory Gestational Trophoblastic Neoplasia (GTN)

Role: lead

NCT01564914Phase 2Completed

A Phase 2 Evaluation of TRC105 In Combination With Bevacizumab in Patients With Glioblastoma

Role: lead

NCT02396511Phase 2Completed

TRC105 Combined With Standard-dose Bevacizumab for Two Patients With Metastatic And Refractory Choriocarcinoma

Role: lead

NCT01326481Phase 1Completed

Open Label Dose-Finding Study of TRC105 Plus Capecitabine for Metastatic Breast Cancer

Role: lead

NCT01381861Phase 2Completed

Evaluation of TRC105 in the Treatment of Recurrent Ovarian, Fallopian Tube, or Primary Peritoneal Carcinoma

Role: lead

NCT01332721Phase 1Completed

Study of TRC105 Combined With Standard-Dose Bevacizumab for Advanced Solid Tumors for Which Bevacizumab is Indicated

Role: lead

NCT00582985Phase 1Completed

Open Label Phase 1 Dose Finding Study of TRC105 in Patients With Solid Cancer

Role: lead