Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

Moderate Risk

Score: 35/100

Failure Rate

11.4%

4 terminated/withdrawn out of 35 trials

Success Rate

88.2%

+1.7% vs industry average

Late-Stage Pipeline

17%

6 trials in Phase 3/4

Results Transparency

10%

3 of 30 completed trials have results

Key Signals

3 with results

Enrollment Performance

Analytics

Phase 2
13(40.6%)
Phase 1
9(28.1%)
Phase 3
6(18.8%)
N/A
2(6.3%)
Early Phase 1
2(6.3%)
32Total
Phase 2(13)
Phase 1(9)
Phase 3(6)
N/A(2)
+1 more

Activity Timeline

Global Presence

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Clinical Trials (35)

Showing 20 of 35 trials
NCT04676529Phase 1Completed

Study to Evaluate Safety, Pharmacokinetic and Pharmacodynamic Dose Escalation and Expansion Study of PXS-5505 in Patients With Primary, Post-polycythemia Vera or Post-essential Thrombocythemia Myelofibrosis

Role: lead

NCT05904717Phase 2Active Not Recruiting

Effect of PXS-4728A on Microglia Activation in Participants With Isolated Rapid Eye Movement Sleep Behaviour Disorder

Role: lead

NCT02134353Phase 3Completed

A Safety and Efficacy Trial of Inhaled Mannitol in Adult Cystic Fibrosis Subjects

Role: lead

NCT00630812Phase 3Completed

Long Term Administration of Inhaled Mannitol in Cystic Fibrosis

Role: lead

NCT04183517Phase 1Completed

A Two-part Pharmacokinetic Study of PXS-5382A in Healthy Adult Males

Role: lead

NCT03620422Not ApplicableCompleted

Mannitol-Induced Cough Challenge in Healthy Controls and Subjects With Mild Allergic Asthma

Role: collaborator

NCT00585260Early Phase 1Completed

Mannitol Bronchoprovocation Challenge Ancillary Study/ACRN

Role: collaborator

NCT02306473Early Phase 1Completed

The Leaky Lung Test

Role: collaborator

NCT00446667Phase 1Withdrawn

A Pilot Safety Study of Inhaled Dry Powder Mannitol in Acute Exacerbations of COPD

Role: lead

NCT00669331Phase 3Completed

Inhaled Mannitol as a Mucoactive Therapy for Bronchiectasis

Role: lead

NCT00117182Phase 2Completed

Aridol Challenge as a Tool to Predict Treatment Response to Inhaled Corticosteroids in COPD

Role: lead

NCT01883531Phase 2Completed

Crossover Trial Determining the Efficacy of Dry Powder Mannitol to Improve Lung Function in Subjects Aged 6-17 Years

Role: lead

NCT00550797Phase 2Completed

Study to Evaluate the Safety and Efficacy TPI ASM8 in Subjects With Asthma

Role: lead

NCT00822861Phase 2Completed

Efficacy and Safety of Four Escalating Dose Regimens of TPI ASM8 in Patients With Allergic Asthma

Role: lead

NCT01158898Phase 2Completed

Efficacy of TPI ASM8 During a 14-Day Allergen Challenge

Role: lead

NCT01380236Phase 2Withdrawn

A Single Blind Study to Evaluate the Safety, Tolerability and Explore the Efficacy of 8.0 mg ASM8 Inhaled Daily for 14 Days in Severe Asthma

Role: lead

NCT00327808Phase 2Completed

Inhaled TPI-1020 Versus Inhaled Budesonide in Smokers With Mild Reversible Asthma

Role: lead

NCT00483743Phase 2Completed

Safety, Tolerability and PD Activity of Inhaled TPI 1020 Versus Inhaled Budesonide in COPD Patients

Role: lead

NCT00264966Phase 1Completed

Multiple Dose ASM8 in Mild Asthmatics

Role: lead

NCT00402948Phase 2Terminated

Safety and Efficacy of Two Dosages of Inhaled TPI ASM8 Compared to Placebo in Mild to Moderate Asthmatic Patients

Role: lead