Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

Moderate Risk

Score: 50/100

Failure Rate

8.3%

1 terminated/withdrawn out of 12 trials

Success Rate

75.0%

-11.5% vs industry average

Late-Stage Pipeline

8%

1 trials in Phase 3/4

Results Transparency

67%

2 of 3 completed trials have results

Key Signals

6 recruiting2 with results

Enrollment Performance

Analytics

Phase 1
6(54.5%)
Phase 2
4(36.4%)
Phase 3
1(9.1%)
11Total
Phase 1(6)
Phase 2(4)
Phase 3(1)

Activity Timeline

Global Presence

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Clinical Trials (12)

Showing 12 of 12 trials
NCT05580770Phase 1Terminated

Mirdametinib + BGB-3245 in Advanced Solid Tumors

Role: lead

NCT07539441Phase 1Recruiting

A Study of Mirdametinib in People With Central Nervous System Tumors

Role: collaborator

NCT04195399Phase 2Active Not Recruiting

A Study of a New Drug, Nirogacestat, for Treating Desmoid Tumors That Cannot be Removed by Surgery

Role: collaborator

NCT05879146Phase 2Recruiting

Evaluation of the Response and Non-response of Nirogacestat in Desmoid Tumors- Clinical Study

Role: collaborator

NCT06159166Phase 1Recruiting

Mirdametinib Monotherapy in Adults With Neurofibromatosis 1 (NF1) and Cutaneous Neurofibromas (cNF).

Role: collaborator

NCT06843967Phase 1Recruiting

A Study of Mirdametinib in Combination With Palbociclib in People With Liposarcoma

Role: collaborator

NCT04923126Phase 1Recruiting

SJ901: Evaluation of Mirdametinib in Children, Adolescents, and Young Adults With Low-Grade Glioma

Role: collaborator

NCT03905148Phase 1Completed

Study of the Safety and Pharmacokinetics of BGB-283 (Lifirafenib) and PD-0325901 (Mirdametinib) in Participants With Advanced or Refractory Solid Tumors

Role: collaborator

NCT05348356Phase 2Completed

Nirogacestat in Ovarian Granulosa Cell Tumors

Role: lead

NCT05949099Phase 2Recruiting

Study of Cryoablation and Nirogacestat for Desmoid Tumor

Role: collaborator

NCT03785964Phase 3Completed

Nirogacestat for Adults With Desmoid Tumor/Aggressive Fibromatosis (DT/AF)

Role: lead

NCT02955446Unknown

Compassionate Use Protocol for PF-03084014 in Patients With Advanced Solid Tumor Malignancies

Role: collaborator

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