Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

Low Risk

Score: 25/100

Failure Rate

7.1%

3 terminated/withdrawn out of 42 trials

Success Rate

91.7%

+5.2% vs industry average

Late-Stage Pipeline

36%

15 trials in Phase 3/4

Results Transparency

12%

4 of 33 completed trials have results

Key Signals

1 recruiting4 with results

Enrollment Performance

Analytics

Phase 2
14(34.1%)
Phase 3
14(34.1%)
Phase 1
12(29.3%)
Phase 4
1(2.4%)
41Total
Phase 2(14)
Phase 3(14)
Phase 1(12)
Phase 4(1)

Activity Timeline

Global Presence

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Clinical Trials (42)

Showing 20 of 42 trials
NCT04903314Phase 1Completed

Dose-Escalation Study of Cenobamate (YKP3089) in Pediatric Subjects With Partial-Onset Seizures

Role: lead

NCT05067634Phase 3Active Not Recruiting

Safety and Efficacy Study of Cenobamate in Pediatric Subjects 2-17 Years of Age With Partial-onset (Focal) Seizures

Role: lead

NCT06453213Phase 4Active Not Recruiting

Open-label Study of Cenobamate Monotherapy in Adult Subjects With Newly Diagnosed or Recurrent Partial-Onset Epilepsy

Role: lead

NCT03961568Phase 3Enrolling By Invitation

Cenobamate Open-Label Extension Study for YKP3089C025

Role: lead

NCT05219617Phase 3Recruiting

Investigate Efficacy and Safety of Carisbamate as Adjunctive Treatment for Seizures Associated With LGS in Children and Adults

Role: lead

NCT03678753Phase 3Completed

Randomized, Double-Blind Study to Evaluate Efficacy and Safety of Cenobamate Adjunctive Therapy in PGTC Seizures

Role: lead

NCT01866111Phase 2Completed

A Double-Blind, Randomized, Placebo-Controlled, Phase 2 Trial of YKP3089 as Adjunctive Therapy in Subjects With Partial Onset Seizures

Role: lead

NCT05388435Phase 1Terminated

Safety, Tolerability, PK/PD & Preliminary Efficacy of SKL27969 in Advanced Solid Tumors Patients

Role: lead

NCT03509285Phase 1Completed

A Study of the Abuse Liability Potential of Cenobamate in Recreational Drug Users

Role: lead

NCT05572255Phase 1Completed

A Randomized, Open-label, Three-way Crossover Study to Evaluate the Relative Bioavailability of 200 Mg Cenobamate Administered Orally

Role: lead

NCT03234699Phase 1Completed

Assess the Influence of Cenobamate on the PK of Cytochrome P450 (CYP) Probe Drugs As a Means of Predicting Drug-drug Interactions

Role: lead

NCT04690751Phase 1Completed

Bioavailability and Food Effect Study of Cenobamate as an Oral Suspension and Tablet

Role: lead

NCT02535091Phase 3Completed

Safety and Pharmacokinetic Study of YKP3089 as Adjunctive Therapy in Subjects With Partial Onset Seizures

Role: lead

NCT04062981Phase 1Completed

Carisbamate Safety Study in Adult and Pediatric Subjects With Lennox-Gastaut Syndrome

Role: lead

NCT04791553Phase 1Completed

Safety Study of Cenobamate in Subjects With Normal Hepatic Function and Subjects With Severe Hepatic Impairment

Role: lead

NCT04505397Phase 1Completed

Single-Dose Escalation Study Followed by a Multiple-Dose Escalation Study of SKL24741 in Healthy Subjects

Role: lead

NCT04557085Phase 3Unknown

Randomized, Double-blind Study to Evaluate Efficacy and Safety of Cenobamate Adjunctive Therapy in POS

Role: lead

NCT03731715Phase 1Completed

Carisbamate in Adult & Pediatric Subjects With Lennox-Gastaut Syndrome

Role: lead

NCT01397968Phase 2Completed

Efficacy and Safety of YKP3089 in Subjects With Treatment Resistant Partial Onset Seizures

Role: lead

NCT04513860Unknown

Cenobamate Expanded Access Program (EAP)

Role: lead