Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 75/100

Failure Rate

15.4%

2 terminated/withdrawn out of 13 trials

Success Rate

50.0%

-36.6% vs industry average

Late-Stage Pipeline

15%

2 trials in Phase 3/4

Results Transparency

0%

0 of 2 completed trials have results

Key Signals

4 recruiting

Enrollment Performance

Analytics

Phase 2
6(46.2%)
Phase 1
5(38.5%)
Phase 3
2(15.4%)
13Total
Phase 2(6)
Phase 1(5)
Phase 3(2)

Activity Timeline

Global Presence

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Clinical Trials (13)

Showing 13 of 13 trials
NCT06008119Phase 3Recruiting

Efficacy and Safety of Tunlametinib Plus Vemurafenib in Patients With BRAF V600E-mutant Metastatic Colorectal Cancer

Role: lead

NCT07507526Phase 2Not Yet Recruiting

A Study of Disitamab Vedotin, Tunlametinib, and PD-1 Antibody for Advanced Gastric Cancer

Role: collaborator

NCT06867393Phase 1Recruiting

Safety, Tolerability, and Pharmacokinetics of HL-003 in Healthy Subjects

Role: lead

NCT06008106Phase 3Recruiting

Comparing Tunlametinib Capsules and Combination Chemotherapy in Advanced NRAS-mutant Melanoma

Role: lead

NCT05900219Phase 2Unknown

Efficacy and Safety of HL-085 Combined With Vemurafenib in BRAF V600E Patients With Non-small Cell Lung Cancer: a Phase II Clinical Study

Role: lead

NCT05263453Phase 2Unknown

HL-085+Vemurafenib to Treat Advanced Melanoma Patients With BRAF V600E/K Mutation

Role: lead

NCT05233332Phase 2Unknown

Study of HL-085 and Vemurafinib in Metastatic Colorectal Cancer (mCRC)

Role: lead

NCT05331105Phase 2Recruiting

HL-085 in Adults With Neurofibromatosis Type 1 (NF1) and Inoperable Plexiform Neurofibromas

Role: lead

NCT03973151Phase 1Completed

Study of HL-085 in NRAS Mutant Advanced Melanoma

Role: lead

NCT05217303Phase 2Completed

HL-085 in NRAS-mutated Advanced Melanoma

Role: lead

NCT03781219Phase 1Unknown

A PhaseI Study of HL-085 Plus Vemurafenib in Solid Tumor With BRAF V600 Mutation

Role: lead

NCT03990077Phase 1Terminated

Study of HL-085 Plus Docetaxel in Patients With KRAS Mutant NSCLC

Role: lead

NCT03976050Phase 1Terminated

Phase I Study of HL-085 in Patients With Advanced Solid Tumors

Role: lead

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