Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

Moderate Risk

Score: 45/100

Failure Rate

5.0%

2 terminated/withdrawn out of 40 trials

Success Rate

94.1%

+7.6% vs industry average

Late-Stage Pipeline

0%

0 trials in Phase 3/4

Results Transparency

25%

8 of 32 completed trials have results

Key Signals

1 recruiting8 with results

Enrollment Performance

Analytics

Phase 1
33(82.5%)
Phase 2
5(12.5%)
N/A
2(5.0%)
40Total
Phase 1(33)
Phase 2(5)
N/A(2)

Activity Timeline

Global Presence

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Clinical Trials (40)

Showing 20 of 40 trials
NCT03503058Phase 2Completed

Safety, Tolerability, Immunogenicity and Protective Efficacy of PfSPZ Vaccine and PfSPZ-CVac in Indonesian Adults Against Naturally-Transmitted Malaria

Role: lead

NCT07558122Phase 1Not Yet Recruiting

Malaria CVD 36000; Gates INV090205

Role: collaborator

NCT06862453Phase 1Recruiting

Safety, Tolerability and Efficacy Against Controlled Human Malaria Infection of PfSPZ-LARC2 Vaccine in Malaria-naïve Adults

Role: lead

NCT06652737Phase 1Completed

Age De-escalation Safety Trial of PfSPZ-LARC2 Vaccine in Burkina Faso

Role: lead

NCT07385287Phase 2Not Yet Recruiting

Field Trial of PfSPZ-LARC2 Vaccine in Burkinabe Adults

Role: lead

NCT05441410Phase 1Not Yet Recruiting

Comparing Safety and Protective Efficacy of Vaccine Candidate PfSPZ-CVac and MVA ME-TRAP/ ChAd63 ME-TRAP in Adults

Role: collaborator

NCT05604521Phase 1Terminated

A Phase 1 Trial of PfSPZ Vaccine in Healthy Adults to Determine Safety, Tolerability and Efficacy Against Heterologous CHMI

Role: lead

NCT04280692Phase 1Suspended

Controlled Human Malaria Infection Transmission Model - Phase A

Role: collaborator

NCT04940130Phase 2Completed

PfSPZ Vaccine Trial in Malian Children

Role: lead

NCT04966871Phase 1Completed

Safety, Tolerability and Efficacy of PfSPZ Vaccine Against Heterologous CHMI in US Malaria naïve Adults

Role: lead

NCT03521973Phase 2Completed

Safety, Tolerability and Protective Efficacy of PfSPZ Vaccine in Gabonese Children

Role: lead

NCT04310085Phase 1Completed

Study in Blood Stage Malaria Infection After DVI of Cryopreserved P. Falciparum (NF54 Strain) Sporozoites

Role: collaborator

NCT03510481Phase 1Completed

Safety, Immunogenicity, and Protective Efficacy of Two Regimens of Radiation Attenuated Plasmodium Falciparum NF54 Sporozoites (PfSPZ Vaccine) During Natural Transmission Season in Healthy African Adults in Mali

Role: collaborator

NCT03083847Phase 1Completed

Dose Escalation PfSPZ-CVac

Role: collaborator

NCT03707041Phase 1Completed

Safety, Tolerability and Chemoprotective Activity of P218 in PfSPZ Challenge Model

Role: collaborator

NCT03590340Phase 1Completed

Regimen Optimization Trial of PfSPZ Vaccine in Equatorial Guinea

Role: lead

NCT01988636Phase 1Completed

Study of Safety and Effectiveness of Intravenous Immunization With PfSPZ Vaccine in Healthy African Adults

Role: collaborator

NCT02858817Phase 1Completed

Safety and Protective Efficacy of IV Immunization With Cryopreserved PfSPZ Under A/P Chemoprophylaxis

Role: collaborator

NCT02687373Phase 1Completed

Safety, Tolerability and Efficacy of PfSPZ Vaccine in Healthy Children and Infants 5 Months - 9 Years Living in Kenya

Role: lead

NCT03420053Phase 1Completed

Study to Evaluate Safety, Immunogenicity and Efficacy of PfSPZ Vaccine in HIV Negative and HIV Positive Tanzanian Adults

Role: lead