Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 60/100

Failure Rate

25.7%

19 terminated/withdrawn out of 74 trials

Success Rate

70.8%

-15.7% vs industry average

Late-Stage Pipeline

23%

17 trials in Phase 3/4

Results Transparency

78%

36 of 46 completed trials have results

Key Signals

2 recruiting36 with results17 terminated

Enrollment Performance

Analytics

Phase 2
33(47.8%)
Phase 1
19(27.5%)
Phase 3
17(24.6%)
69Total
Phase 2(33)
Phase 1(19)
Phase 3(17)

Activity Timeline

Global Presence

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Clinical Trials (74)

Showing 20 of 74 trials
NCT06302348Phase 3Recruiting

A Study of Sepiapterin in Participants With Phenylketonuria (PKU)

Role: lead

NCT05166161Phase 3Active Not Recruiting

A Long-Term Safety Study of PTC923 in Participants With Phenylketonuria

Role: lead

NCT04903288Phase 2Active Not Recruiting

A Study of SmartFlow Magnetic Resonance (MR) Compatible Ventricular Cannula for Administering Eladocagene Exuparvovec to Pediatric Participants

Role: lead

NCT04577352Phase 2Completed

A Study to Assess the Efficacy and Safety of Vatiquinone for the Treatment of Participants With Friedreich Ataxia

Role: lead

NCT07159139Unknown

Vatiquinone Expanded Access Protocol

Role: collaborator

NCT04378075Phase 2Terminated

A Study to Evaluate Efficacy and Safety of Vatiquinone for Treating Mitochondrial Disease in Participants With Refractory Epilepsy

Role: lead

NCT03605550Phase 1Active Not Recruiting

A Phase 1b Study of PTC596 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma and High Grade Glioma

Role: collaborator

NCT03179631Phase 3Completed

Long-Term Outcomes of Ataluren in Duchenne Muscular Dystrophy

Role: lead

NCT01247207Phase 3Completed

Study of Ataluren in Previously Treated Participants With Nonsense Mutation Dystrophinopathy (nmDBMD)

Role: lead

NCT02369731Completed

Registry of Translarna (Ataluren) in Nonsense Mutation Duchenne Muscular Dystrophy (nmDMD)

Role: lead

NCT05358717Phase 2Completed

A Study to Evaluate the Safety and Efficacy of PTC518 in Participants With Huntington's Disease (HD)

Role: lead

NCT05218655Phase 3Completed

A Safety Study for Previously Treated Vatiquinone (PTC743) Participants With Inherited Mitochondrial Disease

Role: lead

NCT05515536Phase 3Active Not Recruiting

A Study to Assess the Safety and Efficacy of Vatiquinone in Participants With Friedreich Ataxia

Role: lead

NCT05485987Phase 2Completed

A Study of Vatiquinone for the Treatment of Participants With Friedreich Ataxia

Role: lead

NCT05349721Phase 2Terminated

Study to Assess the Effects of PTC857 Treatment in Participants With Amyotrophic Lateral Sclerosis ALS

Role: lead

NCT05269355Phase 2Terminated

A Study of Unesbulin in Participants With Advanced Leiomyosarcoma (LMS)

Role: lead

NCT02352896Phase 2Completed

Long-Term Safety and Efficacy Evaluation of EPI-743 in Children With Leigh Syndrome

Role: lead

NCT03206645Phase 1Completed

Unesbulin in Women With Ovarian Cancer Receiving Neoadjuvant Chemotherapy

Role: collaborator

NCT04336826Phase 2Completed

A Study to Evaluate the Safety and Pharmacokinetics of Ataluren in Participants From ≥6 Months to <2 Years of Age With Nonsense Mutation Duchenne Muscular Dystrophy (nmDMD)

Role: lead

NCT03761095Phase 1Completed

A Study of Unesbulin (PTC596) in Combination With Dacarbazine in Participants With Advanced Leiomyosarcoma (LMS)

Role: lead