Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

Moderate Risk

Score: 45/100

Failure Rate

8.7%

2 terminated/withdrawn out of 23 trials

Success Rate

88.9%

+2.4% vs industry average

Late-Stage Pipeline

4%

1 trials in Phase 3/4

Results Transparency

13%

2 of 16 completed trials have results

Key Signals

2 recruiting2 with results

Enrollment Performance

Analytics

Phase 2
13(56.5%)
Phase 1
8(34.8%)
Phase 3
1(4.3%)
Early Phase 1
1(4.3%)
23Total
Phase 2(13)
Phase 1(8)
Phase 3(1)
Early Phase 1(1)

Activity Timeline

Global Presence

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Clinical Trials (23)

Showing 20 of 23 trials
NCT07446322Phase 2Recruiting

FOLFIRI and Bevacizumab With or Without Pelareorep for Second-Line Treatment of Metastatic RAS-Mutated, Microsatellite-Stable Colorectal Cancer

Role: lead

NCT07280377Phase 1Recruiting

A Study in Advanced or Metastatic Gastrointestinal Cancers Exploring Treatment Combinations With Pelareorep and Atezolizumab

Role: lead

NCT04445844Phase 2Active Not Recruiting

INCMGA00012 and Pelareorep for the Treatment of Metastatic Triple Negative Breast Cancer, IRENE Study

Role: collaborator

NCT04215146Phase 2Active Not Recruiting

A Study to Assess Overall Response Rate by Inducing an Inflammatory Phenotype in Metastatic BReast cAnCEr With the Oncolytic Reovirus PeLareorEp in CombinaTion With Anti-PD-L1 Avelumab and Paclitaxel - BRACELET-1 Study

Role: lead

NCT03605719Phase 1Completed

Dexamethasone, Carfilzomib, & Nivolumab With Pelareorep for Relapsed/Refractory Multiple Myeloma

Role: collaborator

NCT01622543Phase 2Completed

Reolysin in Combination With FOLFOX6 and Bevacizumab or FOLFOX6 and Bevacizumab Alone in Metastatic Colorectal Cancer

Role: collaborator

NCT02514382Phase 1Completed

Wild-Type Reovirus, Bortezomib, and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma

Role: collaborator

NCT01708993Phase 2Completed

Reolysin in Previously Treated Advanced/Metastatic, Non Small Cell Lung Cancer Receiving Standard Salvage Therapy

Role: collaborator

NCT01656538Phase 2Completed

A Study of Reolysin For Patients With Advanced/Metastatic Breast Cancer

Role: collaborator

NCT01619813Phase 2Completed

Reolysin Combined With Docetaxel and Prednisone or Docetaxel and Prednisone Alone in Metastatic Castration Resistant Prostate Cancer

Role: collaborator

NCT04102618Early Phase 1Terminated

A Window-of-opportunity Study of Pelareorep in Early Breast Cancer

Role: lead

NCT03015922Phase 1Unknown

Viral Immunotherapy in Relapsed/Refractory Multiple Myeloma

Role: collaborator

NCT01274624Phase 1Completed

Study of REOLYSIN® in Combination With FOLFIRI and Bevacizumab in FOLFIRI Naive Patients With KRAS Mutant Metastatic Colorectal Cancer

Role: lead

NCT02620423Phase 1Completed

Study of Pembrolizumab With REOLYSIN® and Chemotherapy in Patients With Advanced Pancreatic Adenocarcinoma

Role: lead

NCT02723838Phase 1Withdrawn

Study of Intratumoral REOLYSIN® in Combination With Gemcitabine and Cisplatin as Neoadjuvant Therapy in Muscle-invasive Transitional Cell Carcinoma of the Bladder

Role: lead

NCT00998192Phase 2Completed

A Study of REOLYSIN® in Combination With Paclitaxel and Carboplatin in Patients With Squamous Cell Carcinoma of the Lung

Role: lead

NCT00861627Phase 2Completed

Phase 2 Study of REOLYSIN® in Combination With Paclitaxel and Carboplatin for Non-Small Cell Lung Cancer With KRAS or EGFR Activation

Role: lead

NCT00984464Phase 2Completed

Study of REOLYSIN® in Combination With Paclitaxel and Carboplatin in Patients With Metastatic Melanoma

Role: lead

NCT00998322Phase 2Completed

A Study of REOLYSIN® in Combination With Gemcitabine in Patients With Advanced Pancreatic Adenocarcinoma

Role: lead

NCT01166542Phase 3Completed

Efficacy Study of REOLYSIN® in Combination With Paclitaxel and Carboplatin in Platinum-Refractory Head and Neck Cancers

Role: lead