Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 60/100

Failure Rate

13.3%

2 terminated/withdrawn out of 15 trials

Success Rate

85.7%

-0.8% vs industry average

Late-Stage Pipeline

0%

0 trials in Phase 3/4

Results Transparency

0%

0 of 12 completed trials have results

Key Signals

1 recruiting

Enrollment Performance

Analytics

Phase 1
14(93.3%)
Phase 2
1(6.7%)
15Total
Phase 1(14)
Phase 2(1)

Activity Timeline

Global Presence

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Clinical Trials (15)

Showing 15 of 15 trials
NCT05944237Phase 1Recruiting

HTL0039732 in Participants With Advanced Solid Tumours

Role: collaborator

NCT04941989Phase 1Terminated

A Study in Healthy Subjects to Assess the Safety, Tolerability and Pharmacokinetics of HTL0022562

Role: lead

NCT03847207Phase 1Completed

A Study in Healthy Subjects to Assess the Safety, Tolerability, PK and PD of HTL0030310

Role: lead

NCT04935320Phase 1Completed

Comparison of Blood Levels of HTL0016878 From an Oral Capsule and an Oral Solution

Role: lead

NCT04462263Phase 1Completed

Study to Investigate the Receptor Occupancy of HTL0014242 Using [18F] FPEB in Healthy Male Subjects

Role: lead

NCT03785054Phase 1Completed

Phase 1, Healthy Subject, Safety, Tolerability and Pharmacokinetic Study of mGlu5 NAM HTL0014242

Role: lead

NCT04849286Phase 1Completed

Measurement of HTL0016878 in Cerebrospinal Fluid

Role: lead

NCT03244228Phase 1Completed

A Two Part Study to Assess Safety, PK, PD, and Food Effect of Oral HTL0016878

Role: lead

NCT03592862Phase 2Withdrawn

A Study to Assess Safety, Tolerability, and Efficacy of HTL0018318 in Patients With Dementia With Lewy Bodies

Role: lead

NCT03456349Phase 1Completed

Multi-centre Study of HTL0018318 in Patients as an add-on to Standard-of-care

Role: lead

NCT03198624Phase 1Completed

Pharmacokinetics of Oral Capsule in Healthy Japanese vs. Caucasian Subjects

Role: lead

NCT02291783Phase 1Completed

Phase I, Healthy Subject, Safety, Tolerability and Pharmacokinetic Study of an M1 Agonist to Treat Cognitive Impairment

Role: lead

NCT02958696Phase 1Completed

Relative Bioavailability of HTL0018318 Oral Aqueous Solution Versus Capsules

Role: lead

NCT02546310Phase 1Completed

Phase 1 Study Investigating Effects of HTL0009936 on Cognition and BOLD fMRI Signals in Healthy Elderly Subjects

Role: lead

NCT02710188Phase 1Completed

Relative Bioavailability Study in Healthy Subjects to Evaluate the Pharmacokinetics of HTL0009936 After One Dose of Prototype Formulation

Role: lead

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