Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 100/100

Failure Rate

41.7%

15 terminated/withdrawn out of 36 trials

Success Rate

57.1%

-29.4% vs industry average

Late-Stage Pipeline

6%

2 trials in Phase 3/4

Results Transparency

25%

5 of 20 completed trials have results

Key Signals

5 with results14 terminated

Enrollment Performance

Analytics

Phase 1
20(57.1%)
Phase 2
12(34.3%)
Phase 3
2(5.7%)
Early Phase 1
1(2.9%)
35Total
Phase 1(20)
Phase 2(12)
Phase 3(2)
Early Phase 1(1)

Activity Timeline

Global Presence

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Clinical Trials (36)

Showing 20 of 36 trials
NCT02052648Phase 1Completed

Study of IDO Inhibitor and Temozolomide for Adult Patients With Primary Malignant Brain Tumors

Role: lead

NCT02054520Phase 2Terminated

Immunotherapy Study for Patients With Stage IV Melanoma

Role: lead

NCT03301636Phase 2Terminated

A Study of Indoximod or Placebo Plus Pembrolizumab or Nivolumab for Subjects With Unresectable or Metastatic Melanoma

Role: lead

NCT03165188Terminated

Long Term Follow-Up Study for Subjects Previously Treated With Algenpantucel-L (HyperAcute-Pancreas) Immunotherapy

Role: lead

NCT02460367Phase 1Terminated

Immunotherapy Combination Study in Advanced Previously Treated Non-Small Cell Lung Cancer

Role: lead

NCT02035358Phase 1Completed

Immunotherapy Study for Metastatic Renal Cell Cancer

Role: lead

NCT00753740Phase 2Withdrawn

Efficacy Study of Maintenance IT-101 Therapy for Ovarian Cancer Patients.

Role: lead

NCT02380677Phase 1Terminated

Phase 1/2a Dose-Escalation Study of CRLX301 in Patients With Advanced Solid Tumors

Role: lead

NCT02073123Phase 1Completed

Study of IDO Inhibitor in Combination With Checkpoint Inhibitors for Adult Patients With Metastatic Melanoma

Role: lead

NCT02502708Phase 1Completed

Study of the IDO Pathway Inhibitor, Indoximod, and Temozolomide for Pediatric Patients With Progressive Primary Malignant Brain Tumors

Role: lead

NCT02835729Phase 1Completed

A Study of Indoximod in Combination With (7+3) Chemotherapy in Patients With Newly Diagnosed Acute Myeloid Leukemia

Role: lead

NCT03164603Phase 1Completed

NLG802 Indoleamine 2,3-Dioxygenase (IDO) Inhibitor in Advanced Solid Tumors

Role: lead

NCT01380769Phase 2Completed

A Phase 2 Study of CRLX101(NLG207) in Patients With Advanced Non-Small Cell Lung Cancer

Role: lead

NCT03372239Phase 1Completed

Oral Bioavailability,and Food Effect Study and Single Ascending Dose PK Study in Healthy Male Volunteers

Role: lead

NCT02187302Phase 2Completed

CRLX101(NLG207) in Combination With Bevacizumab for Metastatic Renal Cell Carcinoma (mRCC) Versus Standard of Care (SOC)

Role: lead

NCT01792050Phase 2Completed

Study of Chemotherapy in Combination With IDO Inhibitor in Metastatic Breast Cancer

Role: lead

NCT00105053Phase 1Completed

Vaccine Treatment for Hormone Refractory Prostate Cancer

Role: lead

NCT00300612Phase 1Completed

Vaccine Treatment for Advanced Malignant Melanoma

Role: lead

NCT02389985Phase 1Terminated

A Study of CRLX101(NLG207) in Combination With Weekly Paclitaxel in Patients With Recurrent or Persistent Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer

Role: lead

NCT00333502Phase 1Completed

Study of CRLX101 (NLG207) in the Treatment of Advanced Solid Tumors

Role: lead