Key Highlights

Risk & Performance

Pipeline Risk Assessment

Based on historical performance

Moderate Risk

Score: 45/100

Failure Rate

6.9%

5 terminated/withdrawn out of 72 trials

Success Rate

91.5%

+5.0% vs industry average

Late-Stage Pipeline

13%

9 trials in Phase 3/4

Results Transparency

44%

24 of 54 completed trials have results

Key Signals

7 recruiting24 with results

Enrollment Performance

Analytics

N/A

47(78.3%)

Phase 4

8(13.3%)

Phase 1

4(6.7%)

Phase 3

1(1.7%)

60Total

N/A(47)

Phase 4(8)

Phase 1(4)

Phase 3(1)

Activity Timeline

Global Presence

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Clinical Trials (72)

Showing 20 of 72 trials

NCT07115953Not ApplicableRecruiting

Streamlined Denervation With spYral For an Optimized Treatment (SPYRAL SWYFT) in Subjects With Uncontrolled Hypertension

Role: lead

NCT05198674Not ApplicableActive Not Recruiting

SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN

Role: lead

NCT07013929Not ApplicableRecruiting

Spyral InSight Study

Role: lead

NCT01534299Recruiting

Global SYMPLICITY Registry (GSR) DEFINE

Role: lead

NCT06535854Not ApplicableRecruiting

Prevail Global Study

Role: lead

NCT03466151Not ApplicableActive Not Recruiting

RESOLUTE ONYX China RCT Study

Role: lead

NCT07174622Recruiting

Longitudinal Real-world Clinical Outcomes Study on Symplicity Renal Denervation

Role: lead

NCT03471845Not ApplicableActive Not Recruiting

RESOLUTE ONYX China Single Arm Study

Role: lead

NCT06907147Not ApplicableRecruiting

SPYRAL GEMINI Pilot Study

Role: lead

NCT07081243Recruiting

Symplicity China Study

Role: lead

NCT02439775Not ApplicableCompleted

SPYRAL HTN-ON MED Study of Renal Denervation With the Symplicity Spyral™ Multi-electrode Renal Denervation System

Role: lead

NCT02939976Not ApplicableTerminated

Study of Access Site for Enhancing PCI in STEMI for Seniors (SAFE STEMI for Seniors)

Role: collaborator

NCT02439749Not ApplicableCompleted

SPYRAL PIVOTAL - SPYRAL HTN-OFF MED Study

Role: lead

NCT04311086Not ApplicableCompleted

SPYRAL DYSTAL Renal Denervation Global Clinical Study

Role: lead

NCT02064764Not ApplicableCompleted

Renal Nerve Denervation in Patients With Hypertension and Paroxysmal and Persistent Atrial Fibrillation

Role: lead

NCT03584464Not ApplicableCompleted

RESOLUTE ONYX Post-Approval Study (Bifurcation Cohort)

Role: lead

NCT03063749Completed

RESOLUTE ONYX Post-Approval Study

Role: lead

NCT03118531Not ApplicableCompleted

China Resolute Integrity 34/38 mm Study

Role: lead

NCT04011371Not ApplicableCompleted

Cyanoacrylate Closure for Treatment of Venous Leg Ulcers

Role: collaborator

NCT03647475Not ApplicableCompleted

A Single Arm Trial With Resolute Onyx in ONE-Month DAPT for High-Bleeding Risk Patients Who Are Considered One-Month Clear (Onyx ONE Clear)

Role: lead