Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

Low Risk

Score: 5/100

Failure Rate

11.1%

1 terminated/withdrawn out of 9 trials

Success Rate

88.9%

+2.4% vs industry average

Late-Stage Pipeline

67%

6 trials in Phase 3/4

Results Transparency

75%

6 of 8 completed trials have results

Key Signals

6 with results

Enrollment Performance

Analytics

Phase 3
6(66.7%)
Phase 1
2(22.2%)
Phase 2
1(11.1%)
9Total
Phase 3(6)
Phase 1(2)
Phase 2(1)

Activity Timeline

Global Presence

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Clinical Trials (9)

Showing 9 of 9 trials
NCT04820309Phase 3Completed

An Open-label Study to Assess the Long-term Safety, Tolerability, and Efficacy of KarXT in Adult Patients With Schizophrenia (EMERGENT-5)

Role: lead

NCT06605950Phase 1Completed

A Study to Assess the Safety, Tolerability and Pharmacokinetics (PK) of Xanomeline With Trospium Chloride Versus KarXT in Healthy Adult and Elderly Participants of Japanese Ethnicity and to Assess the Effect of Omeprazole on the PK of Xanomeline With Trospium Chloride in Healthy Adult Participants

Role: lead

NCT06572449Phase 3Completed

Study to Assess Safety and Effectiveness of Slowly Increasing Dose and Food Effect of KarXT in Participants With Schizophrenia

Role: lead

NCT04738123Phase 3Completed

A Study to Assess Efficacy and Safety of KarXT in Acutely Psychotic Hospitalized Adult Patients With Schizophrenia (EMERGENT-3)

Role: lead

NCT04659174Phase 3Completed

An Extension Study to Assess Long-term Safety, Tolerability, and Efficacy of KarXT in Adult Patients With Schizophrenia (EMERGENT-4)

Role: lead

NCT05643170Phase 3Terminated

An Open-label Study to Assess the Long-term Safety, Tolerability, Effectiveness, and Durability of Effect of KarXT in Patients With DSM-5 Diagnosis of Schizophrenia

Role: lead

NCT04659161Phase 3Completed

A Study to Assess Efficacy and Safety of KarXT in Acutely Psychotic Hospitalized Adult Patients With Schizophrenia (EMERGENT-2)

Role: lead

NCT03697252Phase 2Completed

A Study to Assess Safety and Efficacy of KarXT in Adult Patients With Schizophrenia

Role: lead

NCT02831231Phase 1Completed

Pilot Study Comparing Effects of Xanomeline Alone to Xanomeline Plus Trospium

Role: lead

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