Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

Moderate Risk

Score: 35/100

Failure Rate

0.0%

0 terminated/withdrawn out of 9 trials

Success Rate

100.0%

+13.5% vs industry average

Late-Stage Pipeline

11%

1 trials in Phase 3/4

Results Transparency

57%

4 of 7 completed trials have results

Key Signals

1 recruiting4 with results

Enrollment Performance

Analytics

Phase 1
7(87.5%)
Phase 3
1(12.5%)
8Total
Phase 1(7)
Phase 3(1)

Activity Timeline

Global Presence

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Clinical Trials (9)

Showing 9 of 9 trials
NCT06922383Phase 1Recruiting

A Clinical Study of Arfolitixorin in Patients With mCRC

Role: lead

NCT03750786Phase 3Completed

A Study to Compare the Efficacy of Arfolitixorin Versus Leucovorin in Combination With 5 Fluorouracil, Oxaliplatin, and Bevacizumab in Patients With Advanced Colorectal Cancer

Role: lead

NCT01987102Phase 1Completed

Investigation of [6R] 5,10-methylenetetrahydrofolate (Arfolitixorin) as Rescue Therapy for Osteosarcoma Patients Treated With HDMTX.

Role: lead

NCT01681472Phase 1Completed

PK/PD Investigation of Modufolin (Arfolitixorin) in Plasma, Tumor and Adjacent Mucosa Adjacent Mucosa in Patients With Colon Cancer

Role: lead

NCT03203564Phase 1Completed

Study Evaluating ECG Effects, Safety, Tolerability and Pharmacokinetics of Single Doses of Modufolin (Arfolitixorin) in Healthy Volunteers Tetrahydrofolate in Healthy Male Volunteers

Role: lead

NCT02244632Phase 1Completed

Modufolin (Arfolitixorin) in Combination With 5-Fluorouracil Alone or Together With Oxaliplatin or Irinotecan in Colorectal Cancer

Role: lead

NCT01397305Phase 1Completed

An Extended Feasibility Phase I/II Study of Methylenetetrahydrofolate (Arfolitixorin) and Pemetrexed Single Agent, Given as Neoadjuvant Treatment in Patients With Resectable Rectal Cancer

Role: lead

NCT04126655Phase 1Unknown

Modelle 001, TS-inhibition in Colorectal Liver Metastases Comparing Arfolitixorin and Calciumfolinate

Role: collaborator

NCT02383901Completed

A Retrospective Non-intervention Study to Characterize FOlate Rescue Treatment in Osteosarcoma Patients Treated With HDMTX

Role: lead

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