Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 75/100

Failure Rate

21.7%

10 terminated/withdrawn out of 46 trials

Success Rate

69.7%

-16.8% vs industry average

Late-Stage Pipeline

9%

4 trials in Phase 3/4

Results Transparency

39%

9 of 23 completed trials have results

Key Signals

10 recruiting9 with results7 terminated

Enrollment Performance

Analytics

Phase 1
32(72.7%)
Phase 2
8(18.2%)
Phase 3
4(9.1%)
44Total
Phase 1(32)
Phase 2(8)
Phase 3(4)

Activity Timeline

Global Presence

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Clinical Trials (46)

Showing 20 of 46 trials
NCT05029635Phase 3Completed

Phase III Study on HMPL-523 for Treatment of ITP

Role: lead

NCT07409428Phase 3Recruiting

A Phase III Study of HMPL-760 Plus R-GemOx VS Placebo Plus R-GemOx in Relapsed/Refractory DLBCL

Role: lead

NCT07396584Phase 1Recruiting

HMPL-A580 in Participants With Advanced or Metastatic Solid Tumor

Role: lead

NCT04762602Phase 1Terminated

A Study of HMPL-306 in Advanced Solid Tumors With IDH Mutations

Role: lead

NCT05494580Phase 1Completed

Pamiparib Plus Surufatinib in Patients With Platinum-resistant Ovarian Cancer

Role: collaborator

NCT03779113Phase 1Terminated

An Open-label, Dose Escalation Trial to Evaluate the Safety and Pharmacokinetics of HMPL-523 in Patients With Lymphoma

Role: lead

NCT07348133Phase 1Completed

Study of Food Effect on Pharmacokinetics of HMPL-523 Acetate Tablets

Role: lead

NCT07331194Phase 1Completed

Pharmacokinetics and Bioequivalence Study of HMPL-523 Acetate Tablets in Humans

Role: lead

NCT04764474Phase 1Terminated

A Study of HMPL-306 in Advanced Hematological Malignancies With mIDH

Role: lead

NCT04353375Phase 2Recruiting

HMPL-453 Tartrate in Advanced Intrahepatic Cholangiocarcinoma

Role: lead

NCT06361888Phase 2Recruiting

A Phase II/III Trial to Evaluate the Efficacy and Safety of Surufatinib Combined With Camrelizumab, Nab-paclitaxel, and Gemcitabine in Metastatic Pancreatic Cancer

Role: lead

NCT07228247Phase 1Recruiting

A Phase Ⅰ/Ⅱa Study of HMPL-A251 in Participants With Advanced or Metastatic HER2-expressing Solid Tumors

Role: lead

NCT06387082Phase 1Recruiting

A Clinical Study of HMPL-506 in Patients With Hematological Malignancies

Role: lead

NCT05077384Phase 1Completed

Open-label Study of Surufatinib in Japanese Patients

Role: lead

NCT06291415Phase 1Withdrawn

The Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of HMPL-523 in Adult Subjects With Immune Thrombocytopenia (ITP)

Role: lead

NCT06387069Phase 3Recruiting

A Study to Evaluate HMPL-306 in Patients With IDH1or IDH2-mutated Acute Myeloid Leukemia

Role: lead

NCT07025018Phase 1Recruiting

Phase I Study of HMPL-306 for the Treatment of Gliomas With IDH1 and/or IDH2 Mutations

Role: lead

NCT06671873Phase 1Completed

Study on Mass Balance of [14C]HMPL-306(Isocitrate Dehydrogenase Inhibitor) in Healthy Chinese Adult Male Subjects

Role: lead

NCT04579679Phase 2Terminated

Open-Label Surufatinib in European Patients With NET

Role: lead

NCT04577963Phase 1Terminated

A Study of Fruquintinib in Combination With Tislelizumab in Advanced Solid Tumors

Role: lead