Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 60/100

Failure Rate

8.5%

4 terminated/withdrawn out of 47 trials

Success Rate

85.7%

-0.8% vs industry average

Late-Stage Pipeline

6%

3 trials in Phase 3/4

Results Transparency

4%

1 of 24 completed trials have results

Key Signals

4 recruiting1 with results

Enrollment Performance

Analytics

Phase 2
23(51.1%)
Phase 1
17(37.8%)
Phase 3
3(6.7%)
N/A
2(4.4%)
45Total
Phase 2(23)
Phase 1(17)
Phase 3(3)
N/A(2)

Activity Timeline

Global Presence

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Clinical Trials (47)

Showing 20 of 47 trials
NCT05782127Phase 1Active Not Recruiting

Oral Azacitidine Combined With Venetoclax in Previously Untreated Higher-risk Myelodysplastic Syndromes

Role: lead

NCT05226455Phase 1Active Not Recruiting

Venetoclax in Patients With MDS or AML in Relapse After AHSCT

Role: lead

NCT05768711Phase 2Active Not Recruiting

Azacitidine Combined With Venetoclax in Patients With Higher-risk Chronic Myelomonocytic Leukemia (AVENHIR)

Role: lead

NCT05181735Phase 1Recruiting

Study Evaluating Combination of Luspatercept in LR-MDS Without RS Having Failed or Being Ineligible to ESA

Role: lead

NCT02938858Active Not Recruiting

French Registry of First-line Treatment of Acute Promyelocytic Leukemia

Role: lead

NCT07098936Phase 2Recruiting

Momelotinib in VEXAS Syndrome

Role: lead

NCT02619565Not ApplicableCompleted

Prospective Study of Molecular Predictors of Survival in Myelodysplastic Syndromes

Role: collaborator

NCT06670222Phase 1Recruiting

Oral Arsenic (ATO) in Low-risk Myelodysplastic Syndromes (MDS)

Role: lead

NCT03503409Phase 2Active Not Recruiting

IDH1 (AG 120) Inhibitor in Patients With IDH1 Mutated Myelodysplastic Syndrome

Role: lead

NCT04827719Phase 2Completed

BST-236 as a Single Agent in Adults With Relapsed or Refractory AML or HR-MDS

Role: lead

NCT03744390Phase 2Active Not Recruiting

IDH2 (AG 221) Inhibitor in Patients With IDH2 Mutated Myelodysplastic Syndrome

Role: lead

NCT04857645Phase 2Completed

ASTX727 and Donor Lymphocyte Infusions After Allogenic Stem Cell Transplantation in Very High Risk MDS or AML Patients

Role: lead

NCT06956755Recruiting

Registry of Myelodysplastic Syndromes and Therapy-related Acute Myeloid Leukemia

Role: lead

NCT05583552Phase 2Active Not Recruiting

Study to Evaluate Imetelstat in Patients With High-Risk MDS or AML Failing HMA-based Therapy

Role: collaborator

NCT03223961Phase 3Active Not Recruiting

A Trial Testing Early vs Late Onset of EPO Alfa Treatment in Lower Risk MDS

Role: lead

NCT02688140Phase 3Completed

Study for Patients With Newly Diagnosed, High-risk Acute Promyelocytic Leukemia

Role: collaborator

NCT00411905Phase 1Completed

Bortezomib and Low Dose Cytarabine in the Treatment of High-risk Myelodysplastic Syndromes

Role: lead

NCT02757989Not ApplicableCompleted

Allogeneic Hematopoietic Stem Cell Transplantation in Patients With Myelodysplastic Syndrome Low Risk

Role: lead

NCT02985190Phase 2Completed

A Study of Azacitidine in Myelodysplastic Syndrome (MDS) Associated to Systemic Auto-immune and Inflammatory Disorders

Role: lead

NCT04273802Phase 1Completed

CPX-351 in Higher Risk Myelodysplastic Syndromes

Role: lead