Global Alliance for TB Drug Development
39
2
4
32
Key Highlights
Risk & Performance
Pipeline Risk Assessment
Pipeline Risk Assessment
Based on historical performance
Moderate Risk
Score: 35/100
5.1%
2 terminated/withdrawn out of 39 trials
94.1%
+7.6% vs industry average
10%
4 trials in Phase 3/4
50%
16 of 32 completed trials have results
Key Signals
Enrollment Performance
Analytics
Activity Timeline
Global Presence
Clinical Trials (39)
Study of a Single Dose of Pretomanid Added to an Optimized Background Regimen in Children With Rifampicin-Resistant Tuberculosis
Role: collaborator
Telacebec (T) Treatment in Adults With Buruli Ulcer (BU).
Role: collaborator
A Phase 3 Trial Assessing Safety and Efficacy of B-Pa-L in Participants With DR-TB
Role: lead
Triage Test for All Oral DR-TB Regimen (TRiAD Study)
Role: collaborator
Study to Evaluate Safety, Tolerability, and the PK Profile of TBI-223 in Healthy Subjects
Role: lead
Evaluate Safety, Tolerability, PK of TBAJ-876 in Healthy Adults
Role: lead
A Pan-TB Regimen Targeting Host and Microbe
Role: collaborator
Efficacy and Safety Evaluation of Two to Four Months of Treatment With the Combination Regimens of DBOS and PBOS in Adults With Pulmonary Tuberculosis
Role: collaborator
Phase 2 Trial Assessing TBAJ876 or Bedaquiline, with Pretomanid and Linezolid in Adults with Drug-sensitive Pulmonary Tuberculosis
Role: lead
A Trial to Evaluate the Male Reproductive Safety of Pretomanid in Adult Male Participants With Drug Resistant Pulmonary Tuberculosis
Role: lead
A Phase 1 Study to Evaluate Safety, Tolerability, and Pharmacokinetics of TBI-223 in Healthy Adults
Role: lead
A Phase 1, Drug-Drug Interaction Study of TBAJ-876 in Healthy Adults
Role: lead
Single-dose Study in Two Panels of Healthy Adult Participants to Assess Immediate-Release and Dispersible Formulations of Pretomanid
Role: lead
Pragmatic Clinical Trial for a More Effective Concise and Less Toxic MDR-TB Treatment Regimen(s)
Role: collaborator
Trial to Evaluate the Efficacy, Safety and Tolerability of BPaMZ in Drug-Sensitive (DS-TB) Adult Patients and Drug-Resistant (DR-TB) Adult Patients
Role: lead
Pharmacokinetic Study of Linezolid for TB Meningitis
Role: collaborator
Various Doses and Durations of Linezolid Plus Bedaquiline & Pretomanid in Participants With Drug Resistant Tuberculosis
Role: lead
Evaluation of the Safety, Tolerability, PK of TBAJ-587 in Healthy Adults
Role: lead
PRACTECAL-PKPD Sub Study
Role: collaborator
Evaluation of Early Bactericidal Activity in Pulmonary Tuberculosis (CL-010)
Role: lead